STRINGSTRING
walR walR walK walK ABD29211.1 ABD29211.1 ABD29212.1 ABD29212.1 ABD29213.1 ABD29213.1 ABD29796.1 ABD29796.1 graX graX graR graR graS graS ABD29800.1 ABD29800.1 ABD29801.1 ABD29801.1 saeS saeS saeR saeR ABD29849.1 ABD29849.1 arlS arlS arlR arlR ABD30867.1 ABD30867.1 ABD30868.1 ABD30868.1 hrtA hrtA hrtB hrtB hssR hssR hssS hssS ABD31653.1 ABD31653.1 ABD31654.1 ABD31654.1 ABD31944.1 ABD31944.1 ABD31945.1 ABD31945.1 ABD31946.1 ABD31946.1 ABD31947.1 ABD31947.1 ABD31948.1 ABD31948.1 ABD32021.1 ABD32021.1 ABD32022.1 ABD32022.1 ABD32057.1 ABD32057.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
walRTwo-component response regulator, putative; Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a transcription regulator by direct binding to promoter regions. Positively controls the cell wall-hydrolytic activity through regulation of atlA and lytM, as well as induces transcription of isaA, sceD, ssaA, and four ssaA- related genes. Binds directly to the lytM, ssaA and is [...] (233 aa)
walKSensory box histidine kinase VicK, putative; Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR. In turn, WalR binds to the upstream promoter regions of the target ge [...] (608 aa)
ABD29211.1Conserved hypothetical protein. (427 aa)
ABD29212.1Conserved hypothetical protein. (262 aa)
ABD29213.1Conserved hypothetical protein. (266 aa)
ABD29796.1Conserved hypothetical protein. (168 aa)
graXConserved hypothetical protein; Plays a role in resistance against cationic antimicrobial peptides (CAMPs). Facilitates the activation of GraS to transduce the signal to GraR. (307 aa)
graRConserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. (224 aa)
graSConserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX. In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confers resistance to vancomycin, polymyxin B, lysozyme and LL-37. (346 aa)
ABD29800.1ABC transporter ATP-binding protein, putative. (253 aa)
ABD29801.1ABC transporter permease, putative. (629 aa)
saeSSensor histidine kinase SaeS, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, hlb), coa, Dnase, spa and cell wall-associated proteins (emp, eap, fnbA). Acts probably downstr [...] (351 aa)
saeRResponse regulator, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (Hla, Hlb), Coa, DNase, Spa and cell wall- associated proteins (Emp, Eap, FnbA). Acts probably downstream of the Agr system in the regulatory c [...] (228 aa)
ABD29849.1Conserved hypothetical protein. (157 aa)
arlSConserved hypothetical protein; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR. ArlS/ArlR affects expression of the multidrug resistance transporter norA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (se [...] (451 aa)
arlRDNA-binding response regulator, putative; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS/ArlR affects expression of the multidrug resistance transporter NorA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the [...] (219 aa)
ABD30867.1Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. (553 aa)
ABD30868.1Two-component response regulator, putative. (234 aa)
hrtAConserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). (221 aa)
hrtBPermease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). (351 aa)
hssRDNA-binding response regulator, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (224 aa)
hssSSensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (457 aa)
ABD31653.1Conserved hypothetical protein. (147 aa)
ABD31654.1Conserved hypothetical protein. (151 aa)
ABD31944.1Permease, putative domain protein. (666 aa)
ABD31945.1ABC transporter, ATP-binding protein, putative. (251 aa)
ABD31946.1Sensor histidine kinase, putative. (295 aa)
ABD31947.1DNA-binding response regulator, putative. (221 aa)
ABD31948.1Conserved hypothetical protein. (66 aa)
ABD32021.1ABC transporter, ATP-binding protein, putative. (252 aa)
ABD32022.1Permease, putative. (626 aa)
ABD32057.1Hypothetical protein. (72 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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