STRINGSTRING
ABD29796.1 ABD29796.1 graX graX graR graR graS graS ABD29800.1 ABD29800.1 ABD29801.1 ABD29801.1 hrtA hrtA hrtB hrtB hssR hssR hssS hssS ABD31653.1 ABD31653.1 ABD31654.1 ABD31654.1 ABD31944.1 ABD31944.1 ABD31945.1 ABD31945.1 ABD31946.1 ABD31946.1 ABD31947.1 ABD31947.1 ABD31948.1 ABD31948.1 ABD32021.1 ABD32021.1 ABD32022.1 ABD32022.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABD29796.1Conserved hypothetical protein. (168 aa)
graXConserved hypothetical protein; Plays a role in resistance against cationic antimicrobial peptides (CAMPs). Facilitates the activation of GraS to transduce the signal to GraR. (307 aa)
graRConserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. (224 aa)
graSConserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX. In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confers resistance to vancomycin, polymyxin B, lysozyme and LL-37. (346 aa)
ABD29800.1ABC transporter ATP-binding protein, putative. (253 aa)
ABD29801.1ABC transporter permease, putative. (629 aa)
hrtAConserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). (221 aa)
hrtBPermease, putative domain protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity). (351 aa)
hssRDNA-binding response regulator, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (224 aa)
hssSSensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (457 aa)
ABD31653.1Conserved hypothetical protein. (147 aa)
ABD31654.1Conserved hypothetical protein. (151 aa)
ABD31944.1Permease, putative domain protein. (666 aa)
ABD31945.1ABC transporter, ATP-binding protein, putative. (251 aa)
ABD31946.1Sensor histidine kinase, putative. (295 aa)
ABD31947.1DNA-binding response regulator, putative. (221 aa)
ABD31948.1Conserved hypothetical protein. (66 aa)
ABD32021.1ABC transporter, ATP-binding protein, putative. (252 aa)
ABD32022.1Permease, putative. (626 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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