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| | ABD29269.1 | 3-ketoacyl-acyl carrier protein reductase, putative. (258 aa) |
| | ABD29294.1 | Alcohol dehydrogenase, iron-containing, putative; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (869 aa) |
| | aldA | Aldehyde dehydrogenase, putative. (495 aa) |
| | ABD29322.1 | Formate dehydrogenase, NAD-dependent, putative; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (341 aa) |
| | ABD29324.1 | Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family. (2391 aa) |
| | ABD29325.1 | Conserved hypothetical protein; Belongs to the P-Pant transferase superfamily. (214 aa) |
| | pflB | Formate acetyltransferase; Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily. (749 aa) |
| | pflA | Pyruvate formate-lyase 1 activating enzyme, putative; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (251 aa) |
| | ABD29373.1 | acetyl-CoA acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | ABD29374.1 | Conserved hypothetical protein; Belongs to the enoyl-CoA hydratase/isomerase family. (753 aa) |
| | ABD29375.1 | Conserved hypothetical protein. (403 aa) |
| | ABD29376.1 | Conserved hypothetical protein. (501 aa) |
| | ABD29377.1 | Conserved hypothetical protein; Belongs to the 3-oxoacid CoA-transferase family. (525 aa) |
| | ldh1 | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate (Potential). Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells (By similarity). (269 aa) |
| | ABD29504.1 | acetyl-CoA acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa) |
| | ABD29526.1 | Phosphoglycerate mutase family protein; Belongs to the phosphoglycerate mutase family. (193 aa) |
| | ABD29594.1 | Glutamate synthase, large subunit, putative. (1499 aa) |
| | ABD29595.1 | NADH-glutamate synthase small subunit, putative. (487 aa) |
| | glmU | UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (450 aa) |
| | prs | Ribose-phosphate pyrophosphokinase, putative; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa) |
| | araB | L-ribulokinase. (545 aa) |
| | ABD29704.1 | Conserved hypothetical protein. (458 aa) |
| | ABD29705.1 | acetyl-CoA acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family. (379 aa) |
| | ABD29717.1 | Phosphate acetyltransferase. (328 aa) |
| | adh | Alcohol dehydrogenase I, putative. (336 aa) |
| | ABD29923.1 | Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa) |
| | pgk | Phosphoglycerate kinase, putative; Belongs to the phosphoglycerate kinase family. (396 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa) |
| | gpmI | Phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa) |
| | ABD30020.1 | Glutamate dehydrogenase, NAD-specific, putative; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (414 aa) |
| | pgi | Glucose-6-phosphate isomerase. (443 aa) |
| | fabH | Conserved hypothetical protein; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (313 aa) |
| | ABD30046.1 | 3-oxoacyl- synthase, putative; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | fabI | Enoyl-(acyl-carrier-protein) reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It has a preference for a long chain (C12) substrate compared to the shorter (C4) acyl group. Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity). (256 aa) |
| | pdhA | Pyruvate dehydrogenase complex, E1 component, alpha subunit, putative; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa) |
| | ABD30161.1 | Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit, putative. (325 aa) |
| | ABD30162.1 | Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex E2, putative. (430 aa) |
| | ABD30163.1 | Dihydrolipoamide dehydrogenase. (468 aa) |
| | ABD30181.1 | Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1150 aa) |
| | ABD30217.1 | Succinate dehydrogenase cytochrome b-558 subunit, putative. (204 aa) |
| | ABD30218.1 | Succinate dehydrogenase, flavoprotein chain TC0881, putative. (588 aa) |
| | ABD30219.1 | Iron-sulphur subunit of succinate dehydrogenase, putative. (271 aa) |
| | ABD30296.1 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (214 aa) |
| | fapR | Conserved hypothetical protein; Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. (190 aa) |
| | plsX | Fatty acid/phospholipid synthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (328 aa) |
| | ABD30304.1 | Malonyl CoA-acyl carrier protein transacylase. (308 aa) |
| | ABD30305.1 | 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa) |
| | sucC | succinyl-CoA synthetase, beta subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa) |
| | sucD | succinyl-CoA synthetase, alpha subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (302 aa) |
| | ABD30358.1 | Conserved hypothetical protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (234 aa) |
| | ABD30367.1 | Conserved hypothetical protein. (586 aa) |
| | ABD30368.1 | Conserved hypothetical protein. (288 aa) |
| | ABD30434.1 | Transketolase; Belongs to the transketolase family. (625 aa) |
| | ABD30443.1 | Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa) |
| | ABD30444.1 | Conserved hypothetical protein. (155 aa) |
| | plsY | Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (202 aa) |
| | acyP | Acylphosphatase. (89 aa) |
| | odhB | 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa) |
| | odhA | 2-oxoglutarate dehydrogenase, E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (932 aa) |
| | birA | BirA bifunctional protein, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (323 aa) |
| | ABD30672.1 | NUDIX domain protein. (180 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (261 aa) |
| | zwf | Glucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (494 aa) |
| | ABD30684.1 | 6-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa) |
| | ABD30690.1 | 2-oxoisovalerate dehydrogenase, E2 component, dihydrolipoamide acetyltransferase, putative. (424 aa) |
| | ABD30691.1 | 2-oxoisovalerate dehydrogenase, E1 component, beta subunit, putative. (327 aa) |
| | ABD30692.1 | 2-oxoisovalerate dehydrogenase, E1 component, alpha subunit, putative. (330 aa) |
| | ABD30693.1 | Dihydrolipoamide dehydrogenase. (473 aa) |
| | ABD30701.1 | acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa) |
| | ABD30702.1 | acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa) |
| | ABD30783.1 | acetyl-CoA carboxylase, biotin carboxylase, putative. (453 aa) |
| | ABD30784.1 | acetyl-CoA carboxylase, biotin carboxyl carrier protein, putative. (149 aa) |
| | ABD30862.1 | Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa) |
| | ABD30869.1 | Isocitrate dehydrogenase, NADP-dependent. (422 aa) |
| | ABD30870.1 | Conserved hypothetical protein; Belongs to the citrate synthase family. (285 aa) |
| | pyk | Pyruvate kinase; Belongs to the pyruvate kinase family. (585 aa) |
| | pfkA | 6-phosphofructokinase, putative; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (307 aa) |
| | accA | acetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa) |
| | accD | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (285 aa) |
| | ABD30878.1 | NADP-dependent malic enzyme, putative. (409 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | ABD30913.1 | acetyl-CoA synthetase, putative. (568 aa) |
| | ABD30914.1 | Conserved hypothetical protein. (210 aa) |
| | ABD30915.1 | Conserved hypothetical protein. (389 aa) |
| | ABD30949.1 | Conserved hypothetical protein. (333 aa) |
| | ABD30964.1 | Conserved hypothetical protein. (237 aa) |
| | pckA | Phosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa) |
| | fumC | Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa) |
| | aldH1 | Aldehyde dehydrogenase, putative; Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of 4,4'- diaponeurosporen-4-al to yield 4,4'-diaponeurosporenoic acid. Belongs to the aldehyde dehydrogenase family. (459 aa) |
| | ABD31191.1 | Conserved hypothetical protein; Belongs to the cycloisomerase 2 family. (342 aa) |
| | ABD31298.1 | Conserved hypothetical protein. (261 aa) |
| | ABD31308.1 | Ammonium transporter. (416 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa) |
| | ABD31320.1 | Acetolactate synthase, large subunit, biosynthetic type. (589 aa) |
| | ABD31321.1 | Conserved hypothetical protein. (84 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (509 aa) |
| | leuB | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (348 aa) |
| | leuC | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (456 aa) |
| | leuD | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (190 aa) |
| | ilvA | Thereonine dehydratase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). (422 aa) |
| | fabZ | beta-hydroxyacyl-ACP dehydratase, putative; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa) |
| | ABD31394.1 | Aldehyde dehydrogenase, putative. (475 aa) |
| | ABD31397.1 | Conserved hypothetical protein. (286 aa) |
| | glmS | Glucosamine--fructose-6-phosphate aminotransferase, isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (601 aa) |
| | glmM | Phosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. (451 aa) |
| | ABD31487.1 | Alpha-acetolactate decarboxylase. (234 aa) |
| | ABD31488.1 | Acetolactate synthase, putative; Belongs to the TPP enzyme family. (554 aa) |
| | rpiA | Ribose 5-phosphate isomerase, putative; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (228 aa) |
| | mqo | Malate:quinone-oxidoreductase. (492 aa) |
| | ABD31660.1 | Conserved hypothetical protein. (300 aa) |
| | gpmA | Phosphoglycerate mutase, putative; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (228 aa) |
| | ABD31764.1 | Glutamate synthase alpha subunit, putative; Belongs to the glutamate synthase family. (525 aa) |
| | ABD31776.1 | Conserved hypothetical protein. (212 aa) |
| | pgcA | Conserved hypothetical protein; Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate (Probable). This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Belongs to the phosphohexose mutase family. (602 aa) |
| | gtaB | UTP-glucose-1-phosphate uridylyltransferase; Catalyzes the formation of UDP-glucose from glucose-1- phosphate and UTP (Probable). This is an intermediate step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). (260 aa) |
| | ABD31849.1 | Pyruvate oxidase, putative; Belongs to the TPP enzyme family. (579 aa) |
| | rocA | Delta-1-pyrroline-5-carboxylate dehydrogenase, putative; Belongs to the aldehyde dehydrogenase family. RocA subfamily. (514 aa) |
| | ABD31873.1 | D-lactate dehydrogenase, putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa) |
| | ldh2 | L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate (Potential). Contributes to S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells, despite playing a secondary role in this resistance mechanism (By similarity). (319 aa) |
| | ABD31919.1 | Conserved hypothetical protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (445 aa) |
| | fda | Fructose-bisphosphate aldolase class-I, putative. (296 aa) |
| | mqo-2 | Malate:quinone-oxidoreductase. (498 aa) |
| | ABD31924.1 | acetyl-CoA synthetase, putative. (532 aa) |
