STRINGSTRING
pflB pflB pflA pflA pdhA pdhA ABD30161.1 ABD30161.1 ABD30162.1 ABD30162.1 ABD30163.1 ABD30163.1 ABD30217.1 ABD30217.1 ABD30218.1 ABD30218.1 ABD30219.1 ABD30219.1 sucC sucC sucD sucD ABD30443.1 ABD30443.1 odhB odhB odhA odhA ABD30690.1 ABD30690.1 ABD30691.1 ABD30691.1 ABD30692.1 ABD30692.1 ABD30693.1 ABD30693.1 ABD30869.1 ABD30869.1 ABD30870.1 ABD30870.1 fumC fumC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pflBFormate acetyltransferase; Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily. (749 aa)
pflAPyruvate formate-lyase 1 activating enzyme, putative; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (251 aa)
pdhAPyruvate dehydrogenase complex, E1 component, alpha subunit, putative; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa)
ABD30161.1Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit, putative. (325 aa)
ABD30162.1Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex E2, putative. (430 aa)
ABD30163.1Dihydrolipoamide dehydrogenase. (468 aa)
ABD30217.1Succinate dehydrogenase cytochrome b-558 subunit, putative. (204 aa)
ABD30218.1Succinate dehydrogenase, flavoprotein chain TC0881, putative. (588 aa)
ABD30219.1Iron-sulphur subunit of succinate dehydrogenase, putative. (271 aa)
sucCsuccinyl-CoA synthetase, beta subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
sucDsuccinyl-CoA synthetase, alpha subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (302 aa)
ABD30443.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
odhB2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa)
odhA2-oxoglutarate dehydrogenase, E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (932 aa)
ABD30690.12-oxoisovalerate dehydrogenase, E2 component, dihydrolipoamide acetyltransferase, putative. (424 aa)
ABD30691.12-oxoisovalerate dehydrogenase, E1 component, beta subunit, putative. (327 aa)
ABD30692.12-oxoisovalerate dehydrogenase, E1 component, alpha subunit, putative. (330 aa)
ABD30693.1Dihydrolipoamide dehydrogenase. (473 aa)
ABD30869.1Isocitrate dehydrogenase, NADP-dependent. (422 aa)
ABD30870.1Conserved hypothetical protein; Belongs to the citrate synthase family. (285 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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