STRINGSTRING
ABD30878.1 ABD30878.1 ABD30869.1 ABD30869.1 aroE aroE ABD30684.1 ABD30684.1 zwf zwf gpsA gpsA ABD30418.1 ABD30418.1 glpD glpD ABD30305.1 ABD30305.1 ABD29991.1 ABD29991.1 murB murB adh adh ABD29683.1 ABD29683.1 guaB guaB ABD29478.1 ABD29478.1 tarJ-2 tarJ-2 tarJ tarJ ABD29393.1 ABD29393.1 ldh1 ldh1 ABD30953.1 ABD30953.1 ABD29322.1 ABD29322.1 ABD29309.1 ABD29309.1 ABD31054.1 ABD31054.1 leuB leuB ABD29374.1 ABD29374.1 ABD29294.1 ABD29294.1 ABD29269.1 ABD29269.1 mtlD mtlD ABD31480.1 ABD31480.1 ABD31586.1 ABD31586.1 ABD31589.1 ABD31589.1 ABD31614.1 ABD31614.1 mqo mqo ABD31745.1 ABD31745.1 ABD31832.1 ABD31832.1 ABD31858.1 ABD31858.1 ABD31873.1 ABD31873.1 ABD31915.1 ABD31915.1 ldh2 ldh2 mqo-2 mqo-2 betA betA hisD hisD ilvC ilvC ABD30914.1 ABD30914.1 ABD30901.1 ABD30901.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABD30878.1NADP-dependent malic enzyme, putative. (409 aa)
ABD30869.1Isocitrate dehydrogenase, NADP-dependent. (422 aa)
aroEShikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (268 aa)
ABD30684.16-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (494 aa)
gpsAGlycerol-3-phosphate dehydrogenase, NAD-dependent, putative; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (332 aa)
ABD30418.1Homoserine dehydrogenase, putative. (426 aa)
glpDConserved hypothetical protein; Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (557 aa)
ABD30305.13-oxoacyl-(acyl-carrier-protein) reductase, putative; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (244 aa)
ABD29991.1D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein. (294 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase, putative; Cell wall formation. (307 aa)
adhAlcohol dehydrogenase I, putative. (336 aa)
ABD29683.1Conserved hypothetical protein; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (321 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (488 aa)
ABD29478.1Conserved hypothetical protein. (341 aa)
tarJ-2Conserved hypothetical protein; Catalyzes the NADPH dependent reduction of D-ribulose 5- phosphate to D-ribitol 5-phosphate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
tarJAlcohol dehydrogenase, zinc-containing; Catalyzes the NADPH dependent reduction of D-ribulose 5- phosphate to D-ribitol 5-phosphate; Belongs to the zinc-containing alcohol dehydrogenase family. (341 aa)
ABD29393.1Sorbitol dehydrogenase, putative. (351 aa)
ldh1L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate (Potential). Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells (By similarity). (269 aa)
ABD30953.1Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (334 aa)
ABD29322.1Formate dehydrogenase, NAD-dependent, putative; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (341 aa)
ABD29309.1cap5O protein/UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (420 aa)
ABD31054.1Conserved hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (348 aa)
ABD29374.1Conserved hypothetical protein; Belongs to the enoyl-CoA hydratase/isomerase family. (753 aa)
ABD29294.1Alcohol dehydrogenase, iron-containing, putative; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (869 aa)
ABD29269.13-ketoacyl-acyl carrier protein reductase, putative. (258 aa)
mtlDMannitol-1-phosphate 5-dehydrogenase, putative. (368 aa)
ABD31480.1Conserved hypothetical protein. (282 aa)
ABD31586.1Conserved hypothetical protein. (360 aa)
ABD31589.1D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain protein. (317 aa)
ABD31614.1Conserved hypothetical protein. (293 aa)
mqoMalate:quinone-oxidoreductase. (492 aa)
ABD31745.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (311 aa)
ABD31832.1D-lactate dehydrogenase, putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa)
ABD31858.1hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (425 aa)
ABD31873.1D-lactate dehydrogenase, putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
ABD31915.12-dehydropantoate 2-reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. (286 aa)
ldh2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate (Potential). Contributes to S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells, despite playing a secondary role in this resistance mechanism (By similarity). (319 aa)
mqo-2Malate:quinone-oxidoreductase. (498 aa)
betACholine dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate. (569 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (416 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
ABD30914.1Conserved hypothetical protein. (210 aa)
ABD30901.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (534 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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