STRINGSTRING
gyrB gyrB gyrA gyrA nnrD nnrD deoB deoB ABD29299.1 ABD29299.1 ABD29301.1 ABD29301.1 ABD29308.1 ABD29308.1 ABD29310.1 ABD29310.1 rbsD rbsD nanE nanE ABD29643.1 ABD29643.1 nagB nagB ABD29701.1 ABD29701.1 tpiA tpiA gpmI gpmI ABD30016.1 ABD30016.1 pgi pgi cdr cdr ABD30069.1 ABD30069.1 ABD30107.1 ABD30107.1 menB menB purE purE murI murI ABD30271.1 ABD30271.1 ABD30296.1 ABD30296.1 topA topA truB truB parE parE parC parC ABD30457.1 ABD30457.1 trpC trpC trpF trpF alr2 alr2 ABD30666.1 ABD30666.1 queA queA hemL1 hemL1 tig tig ABD30918.1 ABD30918.1 ABD30935.1 ABD30935.1 prsA prsA ABD31041.1 ABD31041.1 ABD31046.1 ABD31046.1 hemL2 hemL2 groL groL alr1 alr1 ABD31383.1 ABD31383.1 ABD31416.1 ABD31416.1 glmM glmM ABD31455.1 ABD31455.1 lacB lacB lacA lacA truA truA topB topB rpiA rpiA ABD31624.1 ABD31624.1 fni fni gpmA gpmA pgcA pgcA ABD31965.1 ABD31965.1 hisA hisA
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
Predicted Interactions
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gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (644 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (887 aa)
nnrDConserved hypothetical protein; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. (233 aa)
deoBPhosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (392 aa)
ABD29299.1Capsular polysaccharide biosynthesis protein Cap5E, putative. (342 aa)
ABD29301.1UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (374 aa)
ABD29308.1cap5N protein/UDP-glucose 4-epimerase, putative. (295 aa)
ABD29310.1UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (381 aa)
rbsDRibose ABC transporter protein, putative; Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose. (134 aa)
nanEConserved hypothetical protein; Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N- acetylglucosamine-6-phosphate (GlcNAc-6-P). (222 aa)
ABD29643.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (121 aa)
nagBConserved hypothetical protein; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion. (252 aa)
ABD29701.1SIS domain protein. (167 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
ABD30016.1Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, putative; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity); Belongs to the cyclophilin-type PPIase family. (197 aa)
pgiGlucose-6-phosphate isomerase. (443 aa)
cdrCoenzyme A disulfide reductase, putative; Catalyzes specifically the NADPH-dependent reduction of coenzyme A disulfide. Is also active with other disulfide substrates containing at least one 4'-phosphopantethienyl moiety such as 4,4'- diphosphopantethine, but is not able to reduce oxidized glutathione, cystine, pantethine, or H(2)O(2); Belongs to the class-III pyridine nucleotide-disulfide oxidoreductase family. (438 aa)
ABD30069.1Conserved hypothetical protein. (284 aa)
ABD30107.1Conserved hypothetical protein. (403 aa)
menBenoyl-CoA hydratase/isomerase family protein, putative; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). (273 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (139 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (266 aa)
ABD30271.1Conserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (305 aa)
ABD30296.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (214 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (691 aa)
truBConserved hypothetical protein; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (305 aa)
parEDNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (663 aa)
parCDNA topoisomerase IV, A subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. (800 aa)
ABD30457.14-oxalocrotonate tautomerase, putative. (61 aa)
trpCIndole-3-glycerol phosphate synthase, putative; Belongs to the TrpC family. (260 aa)
trpFN-(5'phosphoribosyl)anthranilate isomerase, putative; Belongs to the TrpF family. (210 aa)
alr2Alanine racemase, putative; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (361 aa)
ABD30666.1Ribosomal large subunit pseudouridine synthase B, putative; Belongs to the pseudouridine synthase RsuA family. (245 aa)
queAS-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (341 aa)
hemL1Glutamate-1-semialdehyde-2,1-aminomutase. (428 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (433 aa)
ABD30918.1Conserved hypothetical protein. (363 aa)
ABD30935.1Ribosomal small subunit pseudouridine synthase A, putative; Belongs to the pseudouridine synthase RsuA family. (231 aa)
prsAProtein export protein PrsA, putative; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (320 aa)
ABD31041.1Ribosomal large subunit pseudouridine synthase, RluD subfamily, putative. (273 aa)
ABD31046.1Conserved hypothetical protein. (199 aa)
hemL2Glutamate-1-semialdehyde-2,1-aminomutase, putative. (391 aa)
groLChaperonin, 60 kDa, GrpEL, putative; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (538 aa)
alr1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (382 aa)
ABD31383.1UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (375 aa)
ABD31416.1Mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (285 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. (451 aa)
ABD31455.1Conserved hypothetical protein. (356 aa)
lacBGalactose-6-phosphate isomerase, LacB subunit. (171 aa)
lacAGalactose-6-phosphate isomerase, LacA subunit. (142 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (267 aa)
topBDNA topoisomerase III, putative; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus remov [...] (711 aa)
rpiARibose 5-phosphate isomerase, putative; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (228 aa)
ABD31624.1Aldose 1-epimerase precursor, putative. (339 aa)
fniConserved hypothetical protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (349 aa)
gpmAPhosphoglycerate mutase, putative; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (228 aa)
pgcAConserved hypothetical protein; Catalyzes the interconversion between glucose-6-phosphate and alpha-glucose-1-phosphate (Probable). This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in the S.aureus membrane, which is also used as a membrane anchor for lipoteichoic acid (LTA). Belongs to the phosphohexose mutase family. (602 aa)
ABD31965.1Mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (312 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase, putative. (234 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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