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| | prfB | Peptide chain release factor 2, putative; Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (291 aa) |
| | hpf | Conserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes; when added to monomeric 70S ribosomes stimulates formation of 100S dimeric ribosomes. Unlike E.coli, 100S ribosomes are present during exponential growth, peak during early stationary phase and then decrease (shown for strain NBRC 3060); Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily. (190 aa) |
| | ABD29894.1 | Conserved hypothetical protein. (213 aa) |
| | saeR | Response regulator, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (Hla, Hlb), Coa, DNase, Spa and cell wall- associated proteins (Emp, Eap, FnbA). Acts probably downstream of the Agr system in the regulatory c [...] (228 aa) |
| | saeS | Sensor histidine kinase SaeS, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, hlb), coa, Dnase, spa and cell wall-associated proteins (emp, eap, fnbA). Acts probably downstr [...] (351 aa) |
| | ABD29839.1 | Conserved hypothetical protein. (254 aa) |
| | mgrA | Conserved hypothetical protein; Regulatory protein involved in autolytic activity, multidrug resistance and virulence. Controls autolysis by inactivating LytM, LytN (autolysins) and SarV (autolysis activator) and activating ArlRS, LrgAB and LytSR (autolysis inhibitors). Acts as a dual regulator for resistance to multiple drugs by inactivating NorB and tet38 and activating NorA. Positively controls the expression of virulence accessory gene regulator (agr) to promote alpha-hemolysin (hla) transcription and down-regulates staphylococcal accessory regulator (sarS), leading to repression o [...] (147 aa) |
| | ABD29812.1 | Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. (288 aa) |
| | ABD29808.1 | Conserved hypothetical protein. (238 aa) |
| | sarX | Conserved hypothetical protein; Involved in the regulation of virulence genes. Acts as a repressor of the agr locus and consequently targets genes regulated by the agr system such as sspA, hla and hlb. Binds directly to the agr promoter region. (141 aa) |
| | ABD29806.1 | Conserved hypothetical protein. (716 aa) |
| | graR | Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. (224 aa) |
| | ABD29773.1 | Conserved hypothetical protein. (214 aa) |
| | sarA | Staphylococcal accessory regulator T, putative; Global regulator with both positive and negative effects that controls expression of several virulence factors and biofilm formation process in a cell density-dependent manner. In a strain-dependent manner plays a role in multidrug resistance mechanism. Is required for transcription of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. Acts as a transcriptional activator of the genes encoding, among others, for fibronectin binding proteins (fnbA and fnbB), hemolysins (hla, hld, hlgB and hlgC) [...] (124 aa) |
| | ABD29724.1 | Conserved hypothetical protein. (138 aa) |
| | tuf | Translation elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (394 aa) |
| | fusA | Translation elongation factor G; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. (693 aa) |
| | rplA | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa) |
| | nusG | Transcription antitermination protein, putative; Participates in transcription elongation, termination and antitermination. (182 aa) |
| | ABD29664.1 | Conserved hypothetical protein; Belongs to the sigma-70 factor family. ECF subfamily. (189 aa) |
| | ctsR | Conserved hypothetical protein; Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. (153 aa) |
| | ABD29647.1 | Conserved hypothetical protein. (460 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the N-terminal section; belongs to the UvrB family. (1168 aa) |
| | rplM | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (145 aa) |
| | ABD29620.1 | Conserved hypothetical protein. (87 aa) |
| | ABD29598.1 | Conserved hypothetical protein. (242 aa) |
| | ABD29593.1 | Transcriptional regulator, lysR family, putative; Belongs to the LysR transcriptional regulatory family. (294 aa) |
| | ABD29483.1 | Conserved hypothetical protein. (139 aa) |
| | ABD29482.1 | Conserved hypothetical protein. (651 aa) |
| | ABD29466.1 | Conserved hypothetical protein. (266 aa) |
| | ABD29417.1 | Conserved hypothetical protein. (332 aa) |
| | ABD29409.1 | Conserved hypothetical protein. (234 aa) |
| | lytR | Two-component response regulator, putative; Member of the two-component regulatory system LytR/LytS that regulates genes involved in autolysis, programmed cell death, biofilm formation and cell wall metabolism. Participates also in sensing and responding to host defense cationic antimicrobial peptides (HDPs). Upon phosphorylation by LytS, functions as a transcription regulator by direct binding to promoter regions of target genes including lrgA and lrgB, to positively regulate their expression. (246 aa) |
| | ABD29389.1 | Conserved hypothetical protein. (698 aa) |
| | hptR | Response regulator receiver domain protein; Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources. Activates uhpT expression to facilitate glucose-6- phosphate/G6P utilization by directly binding to its promoter. Antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility. (252 aa) |
| | ABD29339.1 | Conserved hypothetical protein. (291 aa) |
| | ABD29278.1 | Transcriptional regulator, GntR family, putative. (251 aa) |
| | sarS | Staphylococcal accessory regulator-like protein; Transcriptional regulator that controls expression of some virulence factors in a cell density-dependent manner. Acts as an activator of the gene encoding protein A (spa). Negatively regulates the expression of alpha-hemolysin (hla). (250 aa) |
| | norG | Conserved hypothetical protein; Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Overexpression of norG leads to an increase in the level of resistance to quinolones, associated with a threefold increase in norB transcripts. Disruption of norG leads to an increase in the level of resistance to methicillin, cefotaxime, penicillin G, and nafcillin, associated with a threefold increase in abcA transcripts. Could also have an aminotransferas [...] (465 aa) |
| | ABD29244.1 | Conserved hypothetical protein. (732 aa) |
| | ABD29235.1 | Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. (247 aa) |
| | ABD29233.1 | Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. (286 aa) |
| | ABD29223.1 | Conserved hypothetical protein. (86 aa) |
| | walK | Sensory box histidine kinase VicK, putative; Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR. In turn, WalR binds to the upstream promoter regions of the target ge [...] (608 aa) |
| | walR | Two-component response regulator, putative; Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a transcription regulator by direct binding to promoter regions. Positively controls the cell wall-hydrolytic activity through regulation of atlA and lytM, as well as induces transcription of isaA, sceD, ssaA, and four ssaA- related genes. Binds directly to the lytM, ssaA and is [...] (233 aa) |
| | dnaA | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (453 aa) |
| | ABD29622.1 | Pur operon repressor. (274 aa) |
| | ABD31481.1 | Transcriptional regulator, merR family, putative. (138 aa) |
| | lacR | Lactose phosphotransferase system repressor, putative; Repressor of the lactose catabolism operon. Galactose-6- phosphate is the inducer. (263 aa) |
| | ABD31430.1 | Conserved hypothetical protein. (710 aa) |
| | ABD31419.1 | Conserved hypothetical protein. (106 aa) |
| | ABD31416.1 | Mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (285 aa) |
| | rpoE | DNA-directed RNA polymerase, delta subunit, putative; Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family. (176 aa) |
| | prfA | Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (358 aa) |
| | ABD31356.1 | Conserved hypothetical protein. (97 aa) |
| | kdpE | DNA-binding response regulator, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide synthesis. Upon phosphorylation by KpdD, functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. Represses the transcription of kdpFABC operon. (231 aa) |
| | mazE | Conserved hypothetical protein; Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity; Belongs to the MazE/EndoAI family. (56 aa) |
| | rsbV | STAS domain, putative; Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B (By similarity); Belongs to the anti-sigma-factor antagonist family. (108 aa) |
| | rsbW | Anti-sigma B factor, putative; Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B) (By similarity). (169 aa) |
| | ABD31332.1 | Sigma factor B, putative; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (256 aa) |
| | rex | Conserved hypothetical protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (211 aa) |
| | ABD30868.1 | Two-component response regulator, putative. (234 aa) |
| | infA | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | ABD31545.1 | Conserved hypothetical protein. (146 aa) |
| | sarV | Conserved hypothetical protein; Part of the pathway by which MgrA and SarA control autolysis. Involved in regulation of virulence and autolysis genes such as hla, splA, aur, scp, lrgB, scdA and atl. May also act as an activator for the expression of regulatory genes agr, lytSR and ArlRS. (116 aa) |
| | sarR | Conserved hypothetical protein; Negative regulator of sarA transcription at late exponential and stationary growth phases. It contributes to the modulation of target genes downstream of the sarA regulatory cascade. Also, positively regulates expression of primary transcripts RNAII and RNAIII generated by agr (virulence accessory gene regulator) locus. (115 aa) |
| | ABD31581.1 | Conserved hypothetical protein. (247 aa) |
| | ABD31582.1 | Conserved hypothetical protein. (651 aa) |
| | ABD31596.1 | Conserved hypothetical protein. (230 aa) |
| | ABD31600.1 | Conserved hypothetical protein. (290 aa) |
| | ABD31609.1 | Hex regulon repressor, putative. (254 aa) |
| | ABD31618.1 | Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. (294 aa) |
| | ABD31646.1 | Conserved hypothetical protein. (78 aa) |
| | hssR | DNA-binding response regulator, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (224 aa) |
| | hssS | Sensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (457 aa) |
| | ABD31672.1 | Transcriptional regulator, putative. (701 aa) |
| | sarZ | Conserved hypothetical protein; Activates transcription of virulence factors alpha- and beta hemolysin genes (hla and hlb). Also, activates RNAIII expression, a central regulator transcribed from the agr locus. (148 aa) |
| | ABD31682.1 | Conserved hypothetical protein. (246 aa) |
| | nreC | Conserved hypothetical protein; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity). (200 aa) |
| | ABD31699.1 | Conserved hypothetical protein. (88 aa) |
| | ABD31760.1 | Conserved hypothetical protein. (88 aa) |
| | sarT | Staphylococcal accessory regulator T, putative; Transcriptional regulator acting as an intermediary between major regulators sarA and agr and virulence genes. Represses alpha- hemolysin (hla) gene expression. Down-regulates agr RNAIII expression by repressing sarU, a positive activator of agr expression. Up- regulates sarS, which induces the expression of the cell wall- associated protein A (spa). (106 aa) |
| | sarU | Conserved hypothetical protein; Positive regulator of RNAII and RNAIII in a cell density- dependent manner. It can contribute to the expression of virulence genes controlled by agr. May also regulate target genes via an agr- independent pathway. (247 aa) |
| | ABD31811.1 | Gluconate operon transcriptional repressor, putative. (226 aa) |
| | ABD31812.1 | Conserved hypothetical protein. (254 aa) |
| | ABD31821.1 | Conserved hypothetical protein. (152 aa) |
| | ABD31828.1 | Conserved hypothetical protein. (144 aa) |
| | ABD31852.1 | Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. (275 aa) |
| | ABD31946.1 | Sensor histidine kinase, putative. (295 aa) |
| | ABD31947.1 | DNA-binding response regulator, putative. (221 aa) |
| | ABD31951.1 | Conserved hypothetical protein. (151 aa) |
| | arcR | Conserved hypothetical protein; Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'- TGTGAN(6)TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP. (234 aa) |
| | argR-2 | Conserved hypothetical protein; Regulates arginine biosynthesis genes. (149 aa) |
| | ABD31963.1 | Conserved hypothetical protein. (624 aa) |
| | ABD31965.1 | Mannose-6-phosphate isomerase, class I; Belongs to the mannose-6-phosphate isomerase type 1 family. (312 aa) |
| | icaR | Ica operon transcriptional regulator IcaR, putative; Represses transcription of the icaADBC operon necessary for biofilm production. (186 aa) |
| | ABD32028.1 | Cold shock protein, putative. (75 aa) |
| | nrdR | Conserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (156 aa) |
| | infC | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (175 aa) |
| | ABD30806.1 | Conserved hypothetical protein. (415 aa) |
| | ABD30804.1 | Conserved hypothetical protein. (116 aa) |
| | greA | Transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (158 aa) |
| | rsfS | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (117 aa) |
| | lepA | Conserved hypothetical protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (607 aa) |
| | hrcA | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. (325 aa) |
| | ABD30740.1 | CBS domain protein. (179 aa) |
| | sigA | RNA polymerase sigma factor, putative; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (368 aa) |
| | fur | Conserved hypothetical protein; Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. (136 aa) |
| | efp | Translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (185 aa) |
| | nusB | N utilization substance protein B, putative; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (129 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (150 aa) |
| | ABD30681.1 | Transcriptional regulator, putative. (339 aa) |
| | ABD30679.1 | Conserved hypothetical protein. (297 aa) |
| | ABD30671.1 | Transcriptional regulator, Fur, putative; Belongs to the Fur family. (149 aa) |
| | srrA | DNA-binding response regulator, putative; Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation. Plays also an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate (By similarity). Functions as a transcription regulator by direct binding to promoter regions of target genes (By similarity). (241 aa) |
| | srrB | Staphylococcal respiratory response protein SrrB, putative; Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation. Plays also an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to SrrA. In turn, SrrA binds [...] (583 aa) |
| | ABD30630.1 | Transcriptional activator rinB-related protein. (55 aa) |
| | birA | BirA bifunctional protein, putative; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. (323 aa) |
| | arlR | DNA-binding response regulator, putative; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS/ArlR affects expression of the multidrug resistance transporter NorA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the [...] (219 aa) |
| | cspA | Cold shock protein, putative; Involved in cold stress response and in the susceptibility to an antimicrobial peptide of human cathepsin G (CG117-136). Regulates yellowish-orange pigment production through a still unclear SigB- dependent mechanism. (66 aa) |
| | glcT | Transcriptional antiterminator; Belongs to the transcriptional antiterminator BglG family. GlcT subfamily. (283 aa) |
| | lexA | LexA repressor; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (207 aa) |
| | ABD30412.1 | Conserved hypothetical protein. (200 aa) |
| | ABD30385.1 | Conserved hypothetical protein. (122 aa) |
| | ABD31307.1 | Sucrose operon repressor, putative. (316 aa) |
| | ABD31303.1 | Accessory gene regulator protein A. (208 aa) |
| | ABD31244.1 | Conserved hypothetical phage protein. (49 aa) |
| | ABD31203.1 | Conserved hypothetical protein. (126 aa) |
| | ABD31177.1 | Conserved hypothetical protein. (108 aa) |
| | ABD31174.1 | Conserved hypothetical protein. (100 aa) |
| | vraR | DNA-binding response regulator VraR, putative; Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. Upon cellular stress, the histidine kinase VraS transfers the phosphoryl group onto VraR. Upon phosphorylation, VraR dimerizes at the N-terminal domain. In turn, phosphorylation-induced dimerization expand and enhance the VraR binding to its own promoter leading to increased expression and subsequent modulation of as many as 40 genes, which ultimately constitute the S.aureus response to cell wall damage. In addition, [...] (209 aa) |
| | ABD31105.1 | Transcriptional activator rinb-related protein. (62 aa) |
| | recX | Conserved hypothetical protein; Modulates RecA activity; Belongs to the RecX family. (272 aa) |
| | perR | Ferric uptake regulator-like protein, putative; Manganese-dependent repressor that controls a regulon of oxidative stress resistance and iron-storage proteins. Regulates expression of genes encoding antioxidant proteins, such as katA, ahpCF, bcp and trxB. Also regulates expression of the iron-storage protein ftn, the ferritin-like protein mrgA, the ferric uptake regulator fur, the manganese transporter operon mntABC, and its own expression. May act as a hydrogen peroxide and organic hydroperoxide sensor. Required for full virulence in a murine skin abscess model of infection. (148 aa) |
| | ABD31039.1 | DNA-binding response regulator, putative. (207 aa) |
| | sigS | Conserved hypothetical protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival. (156 aa) |
| | ABD30955.1 | Arsenate operon regulator. (104 aa) |
| | rot | Virulence factor regulator protein; Global regulator with both positive and negative effects that mediates modulation of several genes involved in virulence. Negatively regulates the transcription of several known virulence factors such as lipase (geh), hemolysins (hla and hlb) and proteases (splA through splF, sspB and sspC). Positively regulates the expression of sarS and other genes including those encoding cell surface adhesins (clfB, sdrC and spa). Also, modulates the expression of genes not previously implicated in pathogenesis. (133 aa) |
| | ABD30916.1 | Catabolite control protein A. (329 aa) |
| | rpsD | Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (200 aa) |
| | hfq | Host factor 1 protein, putative; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (77 aa) |
| | ABD30375.1 | Glycerol uptake operon antiterminator regulatory protein, putative; Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA. (180 aa) |
| | ABD30355.1 | Conserved hypothetical protein. (237 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (705 aa) |
| | nusA | Transcription termination-antitermination factor, putative; Participates in both transcription termination and antitermination. (391 aa) |
| | tsf | Translation elongation factor Ts; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (293 aa) |
| | codY | Conserved hypothetical protein; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (257 aa) |
| | hslU | Heat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (467 aa) |
| | fapR | Conserved hypothetical protein; Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism. (190 aa) |
| | ABD30291.1 | Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (435 aa) |
| | mraZ | Conserved hypothetical protein; Belongs to the MraZ family. (143 aa) |
| | mutS2 | DNA mismatch repair MutS2 family protein; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (782 aa) |
| | ABD30165.1 | Conserved hypothetical protein. (179 aa) |
| | ABD30116.1 | Transcriptional regulator, MarR family, putative. (139 aa) |
| | sspC | Cysteine protease, putative; Specifically inhibits the cysteine protease staphopain B (SspB) by blocking the active site of the enzyme. Probably required to protect cytoplasmic proteins from being degraded by prematurely activated/folded prostaphopain B. Also involved in growth capacity, viability and bacterial morphology; Belongs to the protease inhibitor I57 (SspC) family. (109 aa) |
| | prfC | Peptide chain release factor 3; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (520 aa) |
| | spxA | Conserved hypothetical protein; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (131 aa) |
| | ABD30038.1 | Conserved hypothetical protein; Belongs to the LysR transcriptional regulatory family. (289 aa) |
| | ABD29946.1 | Conserved hypothetical protein. (66 aa) |
| | hprK | HPr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...] (310 aa) |
