STRINGSTRING
ABD30806.1 ABD30806.1 ABD30800.1 ABD30800.1 ABD30793.1 ABD30793.1 ABD30774.1 ABD30774.1 nadD nadD ybeY ybeY nfo nfo ABD30725.1 ABD30725.1 ABD30724.1 ABD30724.1 ABD30696.1 ABD30696.1 ABD30692.1 ABD30692.1 ABD30691.1 ABD30691.1 rnz rnz ABD30623.1 ABD30623.1 nth nth ABD30507.1 ABD30507.1 ABD30493.1 ABD30493.1 sbcD sbcD ABD30350.1 ABD30350.1 ABD30319.1 ABD30319.1 trxA trxA ctaA ctaA ABD30165.1 ABD30165.1 ABD30161.1 ABD30161.1 pdhA pdhA ABD30148.1 ABD30148.1 purD purD purF purF ABD30128.1 ABD30128.1 ABD30119.1 ABD30119.1 ABD30107.1 ABD30107.1 ABD30070.1 ABD30070.1 ABD30046.1 ABD30046.1 ABD30039.1 ABD30039.1 ABD30031.1 ABD30031.1 ABD29977.1 ABD29977.1 ABD29974.1 ABD29974.1 ABD29973.1 ABD29973.1 ABD29967.1 ABD29967.1 ABD29939.1 ABD29939.1 ABD29920.1 ABD29920.1 ABD29867.1 ABD29867.1 ABD29853.1 ABD29853.1 ABD29794.1 ABD29794.1 ABD29744.1 ABD29744.1 tadA tadA ABD29688.1 ABD29688.1 ABD29687.1 ABD29687.1 ABD29683.1 ABD29683.1 ABD29679.1 ABD29679.1 mrnC mrnC mcsB mcsB pdxS pdxS ABD29644.1 ABD29644.1 ABD29623.1 ABD29623.1 ABD29621.1 ABD29621.1 ABD29600.1 ABD29600.1 ABD29594.1 ABD29594.1 ychF ychF ABD29478.1 ABD29478.1 ABD29470.1 ABD29470.1 ABD29375.1 ABD29375.1 ABD29374.1 ABD29374.1 argC argC argB argB ABD29324.1 ABD29324.1 ABD29320.1 ABD29320.1 ABD29314.1 ABD29314.1 ABD29308.1 ABD29308.1 ABD29271.1 ABD29271.1 sbnB sbnB ABD29245.1 ABD29245.1 ABD29213.1 ABD29213.1 ABD31984.1 ABD31984.1 ABD31949.1 ABD31949.1 ABD31924.1 ABD31924.1 ABD31882.1 ABD31882.1 ABD31860.1 ABD31860.1 ABD31859.1 ABD31859.1 ABD31858.1 ABD31858.1 ABD31845.1 ABD31845.1 ABD31829.1 ABD31829.1 ABD31764.1 ABD31764.1 ABD31753.1 ABD31753.1 bioB bioB ABD31712.1 ABD31712.1 ABD31694.1 ABD31694.1 ABD31693.1 ABD31693.1 ABD31661.1 ABD31661.1 ABD31636.1 ABD31636.1 fni fni hutG hutG ABD31615.1 ABD31615.1 ABD31569.1 ABD31569.1 ABD31568.1 ABD31568.1 rplV rplV rplP rplP rpsM rpsM truA truA ABD31437.1 ABD31437.1 ABD31420.1 ABD31420.1 ABD31413.1 ABD31413.1 ABD31405.1 ABD31405.1 ABD31336.1 ABD31336.1 ABD31335.1 ABD31335.1 leuA leuA ABD31305.1 ABD31305.1 ABD31297.1 ABD31297.1 ABD31183.1 ABD31183.1 ABD31182.1 ABD31182.1 ABD31157.1 ABD31157.1 ABD31142.1 ABD31142.1 ABD31055.1 ABD31055.1 ABD31034.1 ABD31034.1 hemH hemH ABD31021.1 ABD31021.1 ribBA ribBA ABD30914.1 ABD30914.1 ABD30913.1 ABD30913.1 fhs fhs ABD30900.1 ABD30900.1 ABD30893.1 ABD30893.1 ABD30883.1 ABD30883.1 rplT rplT hemA hemA ABD30807.1 ABD30807.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABD30806.1Conserved hypothetical protein. (415 aa)
ABD30800.1Conserved hypothetical protein. (380 aa)
ABD30793.1Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA. (142 aa)
ABD30774.1Conserved hypothetical protein. (366 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (189 aa)
ybeYConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (155 aa)
nfoEndonuclease IV, putative; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. Belongs to the AP endonuclease 2 family. (296 aa)
ABD30725.1Rhomboid family protein. (336 aa)
ABD30724.1Conserved hypothetical protein. (150 aa)
ABD30696.1Geranyltranstransferase, putative; Belongs to the FPP/GGPP synthase family. (293 aa)
ABD30692.12-oxoisovalerate dehydrogenase, E1 component, alpha subunit, putative. (330 aa)
ABD30691.12-oxoisovalerate dehydrogenase, E1 component, beta subunit, putative. (327 aa)
rnzAtsA/ElaC family protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (306 aa)
ABD30623.1SNF2 family N-terminal domain protein. (455 aa)
nthEndonuclease III, putative; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa)
ABD30507.1Conserved hypothetical protein. (263 aa)
ABD30493.1Conserved hypothetical protein; Belongs to the peptidase M20 family. (383 aa)
sbcDConserved hypothetical protein; SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity (By similarity). Is probably part of the SOS regulon and involved in DNA recombination and repair. (373 aa)
ABD30350.1Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (323 aa)
ABD30319.1Conserved hypothetical protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (294 aa)
trxAThioredoxin; Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). (104 aa)
ctaAHeme A synthase, putative; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. (356 aa)
ABD30165.1Conserved hypothetical protein. (179 aa)
ABD30161.1Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit, putative. (325 aa)
pdhAPyruvate dehydrogenase complex, E1 component, alpha subunit, putative; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa)
ABD30148.1Conserved hypothetical protein. (180 aa)
purDPhosphoribosylamine-glycine ligase; Belongs to the GARS family. (415 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (494 aa)
ABD30128.1Conserved hypothetical protein. (105 aa)
ABD30119.1Conserved hypothetical protein; Could catalyze the transfer of an acetyl group from acetyl coenzyme A (AcCoA) to an acceptor substrate and release both CoA and the acetylated product. (144 aa)
ABD30107.1Conserved hypothetical protein. (403 aa)
ABD30070.1Magnesium transporter; Acts as a magnesium transporter. (461 aa)
ABD30046.13-oxoacyl- synthase, putative; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa)
ABD30039.12-isopropylmalate synthase, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. (381 aa)
ABD30031.1Conserved hypothetical protein; Belongs to the FAH family. (300 aa)
ABD29977.1Conserved hypothetical protein; Belongs to the UPF0051 (ycf24) family. (465 aa)
ABD29974.1Conserved hypothetical protein. (435 aa)
ABD29973.1ABC transporter, ATP-binding protein, putative. (253 aa)
ABD29967.1Conserved hypothetical protein. (98 aa)
ABD29939.1Conserved hypothetical protein. (176 aa)
ABD29920.1Conserved hypothetical protein; Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. (300 aa)
ABD29867.1Conserved hypothetical protein. (180 aa)
ABD29853.16-pyruvoyl tetrahydropterin synthase superfamily, putative. (139 aa)
ABD29794.1Conserved hypothetical protein. (347 aa)
ABD29744.1Conserved hypothetical protein. (431 aa)
tadAConserved hypothetical protein; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (156 aa)
ABD29688.1Conserved hypothetical protein. (205 aa)
ABD29687.1Conserved hypothetical protein. (220 aa)
ABD29683.1Conserved hypothetical protein; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (321 aa)
ABD29679.1Conserved hypothetical protein. (391 aa)
mrnCConserved hypothetical protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (134 aa)
mcsBATP:guanido phosphotransferase, C-terminal catalytic domain protein; Catalyzes the specific phosphorylation of arginine residues in proteins (By similarity). Is required for stress tolerance and virulence in S.aureus. Acts as a modulator of the repressor activity of CtsR upon heavy metal and oxidative stress caused by these metal ions. (335 aa)
pdxSPyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa)
ABD29644.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase. (158 aa)
ABD29623.1Conserved hypothetical protein. (126 aa)
ABD29621.14-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol; Belongs to the GHMP kinase family. IspE subfamily. (282 aa)
ABD29600.1Conserved hypothetical protein. (174 aa)
ABD29594.1Glutamate synthase, large subunit, putative. (1499 aa)
ychFConserved hypothetical protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (365 aa)
ABD29478.1Conserved hypothetical protein. (341 aa)
ABD29470.1Conserved hypothetical protein. (275 aa)
ABD29375.1Conserved hypothetical protein. (403 aa)
ABD29374.1Conserved hypothetical protein; Belongs to the enoyl-CoA hydratase/isomerase family. (753 aa)
argCN-acetylglutamate gamma-semialdehyde dehydrogenase, putative; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa)
argBAcetylglutamate kinase, putative; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (254 aa)
ABD29324.1Conserved hypothetical protein; Belongs to the ATP-dependent AMP-binding enzyme family. (2391 aa)
ABD29320.1Conserved hypothetical protein. (343 aa)
ABD29314.1Conserved hypothetical protein. (319 aa)
ABD29308.1cap5N protein/UDP-glucose 4-epimerase, putative. (295 aa)
ABD29271.1Conserved hypothetical protein. (326 aa)
sbnBOrnithine cyclodeaminase, putative; Catalyzes the hydrolysis of N-((2S)-2-amino-2-carboxyethyl)- L-glutamate (ACEGA) to form L-2,3-diaminopropionic acid and 2- oxoglutarate. Involved in the biosynthesis of L-2,3-diaminopropionic acid (L-Dap), a precursor of staphyloferrin B and antibiotics. Belongs to the ornithine cyclodeaminase/mu-crystallin family. (336 aa)
ABD29245.1Conserved hypothetical protein. (392 aa)
ABD29213.1Conserved hypothetical protein. (266 aa)
ABD31984.1Conserved hypothetical protein. (166 aa)
ABD31949.1Alkaline phosphatase III precursor, putative; Belongs to the alkaline phosphatase family. (474 aa)
ABD31924.1acetyl-CoA synthetase, putative. (532 aa)
ABD31882.1Conserved hypothetical protein. (162 aa)
ABD31860.1methylated-DNA--protein-cysteine methyltransferase, putative; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (173 aa)
ABD31859.1HMG-CoA synthase, putative. (388 aa)
ABD31858.1hydroxymethylglutaryl-CoA reductase, degradative; Belongs to the HMG-CoA reductase family. (425 aa)
ABD31845.1Conserved hypothetical protein. (322 aa)
ABD31829.1Conserved hypothetical protein. (94 aa)
ABD31764.1Glutamate synthase alpha subunit, putative; Belongs to the glutamate synthase family. (525 aa)
ABD31753.1Conserved hypothetical protein. (199 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa)
ABD31712.1Conserved hypothetical protein; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. (288 aa)
ABD31694.1Conserved hypothetical protein. (178 aa)
ABD31693.1Conserved hypothetical protein. (243 aa)
ABD31661.1Conserved hypothetical protein. (111 aa)
ABD31636.1Conserved hypothetical protein. (300 aa)
fniConserved hypothetical protein; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (349 aa)
hutGFormiminoglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (311 aa)
ABD31615.1Conserved hypothetical protein. (373 aa)
ABD31569.1Conserved hypothetical protein. (288 aa)
ABD31568.1Conserved hypothetical protein. (58 aa)
rplVRibosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (117 aa)
rplPRibosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (144 aa)
rpsMConserved hypothetical protein; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa)
truAtRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (267 aa)
ABD31437.1Arginase; Belongs to the arginase family. (302 aa)
ABD31420.1Cation efflux family protein, putative. (326 aa)
ABD31413.1Conserved hypothetical protein. (137 aa)
ABD31405.1Aminobenzoyl-glutamate utilization protein B, putative; Belongs to the peptidase M20A family. (394 aa)
ABD31336.1sigmaB regulation protein RsbU, putative. (96 aa)
ABD31335.1sigmaB regulation protein RsbU, putative. (262 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (509 aa)
ABD31305.1Fructokinase, putative. (319 aa)
ABD31297.1Conserved hypothetical protein. (208 aa)
ABD31183.1Conserved hypothetical protein. (264 aa)
ABD31182.1Nitric oxide synthase, oxygenase domain, putative; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (358 aa)
ABD31157.1UDP-N-acetylmuramyl tripeptide synthetase, putative. (437 aa)
ABD31142.1Conserved hypothetical protein. (176 aa)
ABD31055.1Conserved hypothetical protein. (151 aa)
ABD31034.1Conserved hypothetical protein. (398 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (307 aa)
ABD31021.1Protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. (466 aa)
ribBARiboflavin biosynthesis protein, putative; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (393 aa)
ABD30914.1Conserved hypothetical protein. (210 aa)
ABD30913.1acetyl-CoA synthetase, putative. (568 aa)
fhsFormate-tetrahydrofolate ligase, putative; Belongs to the formate--tetrahydrofolate ligase family. (555 aa)
ABD30900.1Conserved hypothetical protein. (386 aa)
ABD30893.1Conserved hypothetical protein. (382 aa)
ABD30883.1Conserved hypothetical protein; Belongs to the UPF0173 family. (229 aa)
rplTRibosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (448 aa)
ABD30807.1Conserved hypothetical protein. (257 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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