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| | trxA | Thioredoxin; Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). (104 aa) |
| | recF | DNA replication and repair protein, putative; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (370 aa) |
| | gyrB | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (644 aa) |
| | ABD29207.1 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (466 aa) |
| | ABD29220.1 | Conserved hypothetical protein. (150 aa) |
| | ABD29228.1 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (310 aa) |
| | ABD29230.1 | Conserved hypothetical protein. (98 aa) |
| | sbnI | Conserved hypothetical protein; Free serine kinase that uses ATP to phosphorylate L-serine to yield O-phospho-L-serine and ADP. O-phospho-L-serine serves as a substrate for SbnA and is a precursor for staphyloferrin B biosynthesis. Is also a DNA-binding regulatory protein that senses heme to control gene expression for siderophore biosynthesis. Binds to DNA within the sbnC coding region and is required for expression of genes in the sbn operon from sbnD onward. (254 aa) |
| | ABD29271.1 | Conserved hypothetical protein. (326 aa) |
| | ABD29308.1 | cap5N protein/UDP-glucose 4-epimerase, putative. (295 aa) |
| | ABD29476.1 | Conserved hypothetical protein. (314 aa) |
| | ABD29478.1 | Conserved hypothetical protein. (341 aa) |
| | ABD29510.1 | Chromosome partioning protein, ParB family, putative; Belongs to the ParB family. (281 aa) |
| | rpsF | Ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (98 aa) |
| | rpsR | Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (80 aa) |
| | ABD29602.1 | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (105 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (198 aa) |
| | rnmV | Conserved hypothetical protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step; Belongs to the ribonuclease M5 family. (178 aa) |
| | rplY | Ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (217 aa) |
| | ABD29636.1 | S1 RNA binding domain protein. (133 aa) |
| | pdxS | Pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (295 aa) |
| | rplK | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (140 aa) |
| | rplA | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (230 aa) |
| | rplJ | Ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (166 aa) |
| | rplL | Ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa) |
| | rpsG | Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | ABD29683.1 | Conserved hypothetical protein; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (321 aa) |
| | ABD29744.1 | Conserved hypothetical protein. (431 aa) |
| | graS | Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX. In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confers resistance to vancomycin, polymyxin B, lysozyme and LL-37. (346 aa) |
| | ABD29850.1 | Conserved hypothetical protein. (146 aa) |
| | ABD29863.1 | ATP-dependent DNA helicase RecQ. (593 aa) |
| | hpf | Conserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes; when added to monomeric 70S ribosomes stimulates formation of 100S dimeric ribosomes. Unlike E.coli, 100S ribosomes are present during exponential growth, peak during early stationary phase and then decrease (shown for strain NBRC 3060); Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily. (190 aa) |
| | ABD29966.1 | Conserved hypothetical protein. (128 aa) |
| | ABD30017.1 | Conserved hypothetical protein. (114 aa) |
| | ABD30159.1 | Conserved hypothetical protein. (208 aa) |
| | rpmF | Ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (43 aa) |
| | ABD30265.1 | Conserved hypothetical protein. (268 aa) |
| | priA | Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (802 aa) |
| | rpmB | Ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (62 aa) |
| | smc | SMC family, C-terminal domain family; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1188 aa) |
| | rpsP | Ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (91 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (691 aa) |
| | rpsB | Ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (243 aa) |
| | ABD30346.1 | Conserved hypothetical protein. (105 aa) |
| | rpsO | Ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | rpmG1 | Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa) |
| | rpsN | Ribosomal protein S14p/S29e; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site; Belongs to the universal ribosomal protein uS14 family. (89 aa) |
| | parE | DNA topoisomerase IV, B subunit; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (663 aa) |
| | ABD30507.1 | Conserved hypothetical protein. (263 aa) |
| | ebh | Conserved hypothetical protein; Promotes bacterial attachment to both soluble and immobilized forms of fibronectin (Fn), in a dose-dependent and saturable manner. (9535 aa) |
| | nth | Endonuclease III, putative; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (219 aa) |
| | ABD30555.1 | Conserved hypothetical protein. (228 aa) |
| | ABD30575.1 | DNA-binding protein HU, putative; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. (90 aa) |
| | ABD30578.1 | 30S ribosomal protein S1, putative. (391 aa) |
| | ABD30586.1 | ATP-dependent DNA helicase RecQ, putative. (459 aa) |
| | ABD30623.1 | SNF2 family N-terminal domain protein. (455 aa) |
| | ABD30626.1 | Conserved hypothetical phage protein. (96 aa) |
| | ABD30627.1 | Conserved hypothetical phage protein. (86 aa) |
| | ABD30628.1 | Conserved hypothetical phage protein. (665 aa) |
| | ABD30694.1 | DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (559 aa) |
| | ABD30706.1 | Conserved hypothetical protein. (72 aa) |
| | rpmG2 | Ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (49 aa) |
| | cshB | Conserved hypothetical protein; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (448 aa) |
| | dnaG | DNA primase, putative; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (599 aa) |
| | recO | Conserved hypothetical protein; Involved in DNA repair and RecF pathway recombination. (248 aa) |
| | ABD30746.1 | Diacylglycerol kinase, putative. (114 aa) |
| | rpsU | Ribosomal protein S21; Belongs to the bacterial ribosomal protein bS21 family. (58 aa) |
| | rpsT | Ribosomal protein S20; Binds directly to 16S ribosomal RNA. (83 aa) |
| | ABD30766.1 | Conserved hypothetical protein. (143 aa) |
| | ABD30768.1 | Conserved hypothetical protein. (238 aa) |
| | udk | Uridine kinase. (207 aa) |
| | ABD30806.1 | Conserved hypothetical protein. (415 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (150 aa) |
| | rpmA | Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. (94 aa) |
| | rplU | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa) |
| | ABD30832.1 | Conserved hypothetical protein; Belongs to the UPF0758 family. (218 aa) |
| | rpmI | Ribosomal protein L35; Belongs to the bacterial ribosomal protein bL35 family. (66 aa) |
| | ABD30859.1 | Conserved hypothetical protein. (306 aa) |
| | ABD30860.1 | Conserved hypothetical protein. (466 aa) |
| | ABD30880.1 | Conserved hypothetical protein. (313 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa) |
| | ezrA | Conserved hypothetical protein; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (564 aa) |
| | ABD30971.1 | Conserved hypothetical protein. (302 aa) |
| | ABD31095.1 | Phi Mu50B-like protein. (95 aa) |
| | ABD31119.1 | Bacteriophage L54a, DnaB-like helicase family protein. (413 aa) |
| | ABD31121.1 | Phi PV83 orf 20-like protein. (268 aa) |
| | ABD31182.1 | Nitric oxide synthase, oxygenase domain, putative; Catalyzes the production of nitric oxide. Belongs to the NOS family. Bacterial NOS oxygenase subfamily. (358 aa) |
| | ABD31258.1 | Phage DnaC-like protein. (259 aa) |
| | ABD31259.1 | Phi ETA orf 22-like protein. (256 aa) |
| | ABD31284.1 | Conserved hypothetical protein. (407 aa) |
| | cshA | ATP-dependent RNA helicase, DEAD box family, putative; A probable ATP-dependent RNA helicase with RNA-dependent ATPase activity. Involved in regulation of biofilm formation and hemolysis via its effects on stability of mRNA from the agrBDCA operon. Also involved in response to cold stress. (506 aa) |
| | rpmE2 | Ribosomal protein L31. (84 aa) |
| | cobB | Transcriptional regulator, Sir2 family, putative; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. (246 aa) |
| | rpsI | Ribosomal protein S9, putative; Belongs to the universal ribosomal protein uS9 family. (132 aa) |
| | rplM | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (145 aa) |
| | rplQ | Ribosomal protein L17. (122 aa) |
| | rpsK | Ribosomal protein S11, putative; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (129 aa) |
| | rpmJ | Ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (37 aa) |
| | rplO | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa) |
| | rpmD | Ribosomal protein L30. (59 aa) |
| | rpsE | Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (166 aa) |
| | rplR | Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (119 aa) |
| | rpsH | Ribosomal protein S8, putative; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rpsZ | Ribosomal protein S14p/S29e, putative; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (56 aa) |
| | rplE | 50S ribosomal protein L5, putative; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rplN | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rpsQ | 30S ribosomal protein S17, putative; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (87 aa) |
| | rpmC | Ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (69 aa) |
| | rpsC | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (217 aa) |
| | rplB | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (277 aa) |
| | rplW | Ribosomal protein L23, putative; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (91 aa) |
| | rplC | Ribosomal protein L3, putative; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (220 aa) |
| | topB | DNA topoisomerase III, putative; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus remov [...] (711 aa) |
| | ABD31636.1 | Conserved hypothetical protein. (300 aa) |
| | ABD31845.1 | Conserved hypothetical protein. (322 aa) |
| | crtN | Squalene synthase, putative; Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes three successive dehydrogenation reactions that lead to the introduction of three double bonds into 4,4'-diapophytoene (dehydrosqualene), with 4,4'- diapophytofluene and 4,4'-diapo-zeta-carotene as intermediates, and 4,4'-diaponeurosporene (the major deep-yellow pigment in staphylococci strains) as the end product. (502 aa) |
| | crtP | Conserved hypothetical protein; Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of the terminal methyl side group of 4,4'- diaponeurosporene to form 4,4'-diaponeurosporen-4-al. (497 aa) |
| | ABD31946.1 | Sensor histidine kinase, putative. (295 aa) |
| | ABD32032.1 | Conserved hypothetical protein; Belongs to the ParB family. (279 aa) |
| | rpmH | Ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (45 aa) |
