STRINGSTRING
recA recA ABD30409.1 ABD30409.1 nikE nikE nikD nikD pstB pstB ABD30487.1 ABD30487.1 ABD30732.1 ABD30732.1 recD2 recD2 ABD30806.1 ABD30806.1 ruvB ruvB clpX clpX ABD31009.1 ABD31009.1 ABD31027.1 ABD31027.1 ABD31049.1 ABD31049.1 ABD31059.1 ABD31059.1 ABD31065.1 ABD31065.1 ABD31200.1 ABD31200.1 ABD31202.1 ABD31202.1 ABD31312.1 ABD31312.1 atpD atpD rho rho ABD31427.1 ABD31427.1 ABD31492.1 ABD31492.1 ecfA2 ecfA2 ecfA1 ecfA1 ABD31560.1 ABD31560.1 ABD31628.1 ABD31628.1 hrtA hrtA ABD31705.1 ABD31705.1 ABD31726.1 ABD31726.1 ABD31727.1 ABD31727.1 ABD31750.1 ABD31750.1 ABD31758.1 ABD31758.1 cntF cntF cntD cntD ABD31822.1 ABD31822.1 ABD31834.1 ABD31834.1 clpL clpL ABD31945.1 ABD31945.1 ABD32005.1 ABD32005.1 ABD32021.1 ABD32021.1 dnaA dnaA phnC phnC ABD29317.1 ABD29317.1 ABD29345.1 ABD29345.1 ABD29353.1 ABD29353.1 ABD29424.1 ABD29424.1 ABD29457.1 ABD29457.1 ABD29501.1 ABD29501.1 metN1 metN1 dnaX dnaX ftsH ftsH clpC clpC radA radA ABD29772.1 ABD29772.1 tagH tagH ABD29782.1 ABD29782.1 ABD29786.1 ABD29786.1 ABD29800.1 ABD29800.1 ABD29825.1 ABD29825.1 ABD29826.1 ABD29826.1 ABD29862.1 ABD29862.1 ABD29864.1 ABD29864.1 ABD29881.1 ABD29881.1 uvrA uvrA metN2 metN2 ABD29973.1 ABD29973.1 clpB clpB ABD30050.1 ABD30050.1 ABD30051.1 ABD30051.1 ABD30054.1 ABD30054.1 ABD30055.1 ABD30055.1 ABD30095.1 ABD30095.1 ABD30142.1 ABD30142.1 potA potA ftsY ftsY ffh ffh hslU hslU ABD30354.1 ABD30354.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
recARecombination protein RecA, putative; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (322 aa)
ABD30409.1ABC transporter, ATP-binding protein, putative. (302 aa)
nikEOligopeptide ABC transporter, ATP-binding protein, putative; Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import. Probably responsible for energy coupling to the transport system. Required for full urease activity and plays a significant role in the virulence of S.aureus during urinary tract infection (UTI). (233 aa)
nikDPeptide ABC transporter, ATP-binding protein, putative; Part of the ABC transporter complex NikABCDE (Opp2) involved in nickel import. Probably responsible for energy coupling to the transport system. Required for full urease activity and plays a significant role in the virulence of S.aureus during urinary tract infection (UTI). (257 aa)
pstBPhosphate ABC transporter ATP-binding protein, putative; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (283 aa)
ABD30487.1ABC transporter, ATP-binding protein, putative. (533 aa)
ABD30732.1ABC transporter, putative. (261 aa)
recD2Conserved hypothetical protein; DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity; Belongs to the RecD family. RecD-like subfamily. (825 aa)
ABD30806.1Conserved hypothetical protein. (415 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (334 aa)
clpXATP-dependent Clp protease, ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (420 aa)
ABD31009.1ABC transporter domain protein. (230 aa)
ABD31027.1ABC transporter, ATP-binding protein, putative. (246 aa)
ABD31049.1Amino acid ABC transporter, ATP-binding protein, putative. (242 aa)
ABD31059.1ABC transporter, ATP-binding/permease protein, putative; May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity); Belongs to the ABC transporter superfamily. (578 aa)
ABD31065.1Conserved hypothetical protein. (505 aa)
ABD31200.1ABC transporter, ATP-binding protein, putative. (290 aa)
ABD31202.1ABC transporter, ATP-binding protein, putative. (298 aa)
ABD31312.1ABC transporter, ATP-binding protein, putative. (642 aa)
atpDATP synthase F1, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (470 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (438 aa)
ABD31427.1ABC transporter, ATP-binding protein, putative. (260 aa)
ABD31492.1Conserved hypothetical protein. (378 aa)
ecfA2ABC transporter, ATP-binding protein, putative; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (286 aa)
ecfA1ABC transporter, ATP-binding protein, putative; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (269 aa)
ABD31560.1Molybdenum transport ATP-binding protein ModC, putative. (201 aa)
ABD31628.1Conserved hypothetical protein. (299 aa)
hrtAConserved hypothetical protein; Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system (By similarity). (221 aa)
ABD31705.1Amino acid ABC transporter, ATP-binding protein, putative. (243 aa)
ABD31726.1Conserved hypothetical protein. (577 aa)
ABD31727.1Conserved hypothetical protein. (587 aa)
ABD31750.1Amino acid ABC transporter, ATP-binding protein, putative. (408 aa)
ABD31758.1ABC transporter, ATP-binding protein, putative. (220 aa)
cntFPeptide ABC transporter, ATP-binding protein, putative; Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Probably responsible for energy coupling to the transport system. Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro. (249 aa)
cntDPeptide ABC transporter, ATP-binding protein, putative; Part of the ABC transporter complex CntABCDF (Opp1) involved in the uptake of metal in complex with the metallophore staphylopine (StP). Involved in the import of divalent metals ions such as nickel, cobalt and zinc. Probably responsible for energy coupling to the transport system. Plays a major role in nickel/cobalt import in zinc-depleted conditions. Contributes to virulence. Required for full urease activity in vitro. (271 aa)
ABD31822.1Conserved hypothetical protein. (231 aa)
ABD31834.1Conserved hypothetical protein. (211 aa)
clpLATP-dependent Clp protease, ATP-binding subunit ClpC, putative; Required for the development of induced thermotolerance and intracellular multiplication within bovine mammary epithelial cells. (701 aa)
ABD31945.1ABC transporter, ATP-binding protein, putative. (251 aa)
ABD32005.1ABC transporter, ATP-binding protein, putative. (570 aa)
ABD32021.1ABC transporter, ATP-binding protein, putative. (252 aa)
dnaAChromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (453 aa)
phnCAmino acid ABC transporter, ATP-binding protein, putative; Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphonates importer (TC 3.A.1.9.1) family. (257 aa)
ABD29317.1Conserved hypothetical protein. (246 aa)
ABD29345.1Peptide ABC transporter, ATP-binding protein, putative; Belongs to the ABC transporter superfamily. (530 aa)
ABD29353.1Multiple sugar-binding transport ATP-binding protein, putative; Belongs to the ABC transporter superfamily. (365 aa)
ABD29424.1Conserved hypothetical protein. (219 aa)
ABD29457.1ABC transporter, ATP-binding protein, putative. (225 aa)
ABD29501.1ABC transporter, ATP-binding protein, putative. (280 aa)
metN1Conserved hypothetical protein; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (341 aa)
dnaXDNA polymerase III, gamma and tau subunits, putative; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (557 aa)
ftsHConserved hypothetical protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (697 aa)
clpCEndopeptidase, putative; Required for growth at high temperatures, probably by acting as a chaperone during heat shock and targeting heat-denatured proteins for degradation by ClpP. Required for biofilm formation. May act as a chaperone regulating CtsR activity. (818 aa)
radADNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (444 aa)
ABD29772.1Conserved hypothetical protein. (247 aa)
tagHTeichoic acid translocation ATP-binding protein, putative; Part of the ABC transporter complex TagGH involved in teichoic acids export. Responsible for energy coupling to the transport system. (264 aa)
ABD29782.1Conserved hypothetical protein. (575 aa)
ABD29786.1Iron compound ABC transporter, ATP-binding protein. (265 aa)
ABD29800.1ABC transporter ATP-binding protein, putative. (253 aa)
ABD29825.1Conserved hypothetical protein. (543 aa)
ABD29826.1Conserved hypothetical protein. (557 aa)
ABD29862.1ABC transporter, ATP-binding protein. (627 aa)
ABD29864.1ABC transporter domain protein. (325 aa)
ABD29881.1Conserved hypothetical protein. (253 aa)
uvrAExcinuclease ABC, A subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (948 aa)
metN2ABC transporter, ATP-binding protein, putative; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system. (341 aa)
ABD29973.1ABC transporter, ATP-binding protein, putative. (253 aa)
clpBATP-dependent Clp protease, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (869 aa)
ABD30050.1Conserved hypothetical protein; Belongs to the ABC transporter superfamily. (360 aa)
ABD30051.1Oligopeptide ABC transporter, ATP-binding protein, putative; Belongs to the ABC transporter superfamily. (313 aa)
ABD30054.1Oligopeptide ABC transporter, ATP-binding protein, putative; Belongs to the ABC transporter superfamily. (328 aa)
ABD30055.1Oligopeptide ABC transporter, ATP-binding protein, putative; Belongs to the ABC transporter superfamily. (326 aa)
ABD30095.1ABC transporter, ATP-binding protein, putative. (213 aa)
ABD30142.1Conserved hypothetical protein. (466 aa)
potAABC transporter domain protein; Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family. (364 aa)
ftsYSignal recognition particle-docking protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). (416 aa)
ffhSignal recognition particle protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (455 aa)
hslUHeat shock protein HslVU, ATPase subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. (467 aa)
ABD30354.1Conserved hypothetical protein; Belongs to the FtsK/SpoIIIE/SftA family. (747 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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