STRINGSTRING
pflB pflB ABD31931.1 ABD31931.1 ABD31924.1 ABD31924.1 mqo-2 mqo-2 ldh2 ldh2 ABD31908.1 ABD31908.1 ABD31890.1 ABD31890.1 ABD31873.1 ABD31873.1 ABD31849.1 ABD31849.1 ABD31832.1 ABD31832.1 mqo mqo ABD31480.1 ABD31480.1 ABD31404.1 ABD31404.1 ABD31394.1 ABD31394.1 leuA leuA aldH1 aldH1 ABD31054.1 ABD31054.1 fumC fumC pckA pckA ABD30970.1 ABD30970.1 ABD30939.1 ABD30939.1 ABD30913.1 ABD30913.1 ackA ackA ABD30878.1 ABD30878.1 accD accD accA accA pyk pyk ABD30784.1 ABD30784.1 ABD30783.1 ABD30783.1 ABD30720.1 ABD30720.1 ABD30702.1 ABD30702.1 ABD30701.1 ABD30701.1 ABD30693.1 ABD30693.1 ABD30683.1 ABD30683.1 acyP acyP ABD30368.1 ABD30368.1 ABD30367.1 ABD30367.1 ABD30181.1 ABD30181.1 ABD30163.1 ABD30163.1 ABD30162.1 ABD30162.1 ABD30161.1 ABD30161.1 pdhA pdhA ABD30039.1 ABD30039.1 ABD29845.1 ABD29845.1 ABD29723.1 ABD29723.1 ABD29717.1 ABD29717.1 ABD29705.1 ABD29705.1 hchA hchA ABD29495.1 ABD29495.1 ABD29494.1 ABD29494.1 ldh1 ldh1 ABD29377.1 ABD29377.1 aldA aldA ABD29294.1 ABD29294.1 ABD29225.1 ABD29225.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pflBFormate acetyltransferase; Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily. (749 aa)
ABD31931.1Conserved hypothetical protein. (228 aa)
ABD31924.1acetyl-CoA synthetase, putative. (532 aa)
mqo-2Malate:quinone-oxidoreductase. (498 aa)
ldh2L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate (Potential). Contributes to S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells, despite playing a secondary role in this resistance mechanism (By similarity). (319 aa)
ABD31908.1Conserved hypothetical protein. (149 aa)
ABD31890.1Conserved hypothetical protein. (125 aa)
ABD31873.1D-lactate dehydrogenase, putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (332 aa)
ABD31849.1Pyruvate oxidase, putative; Belongs to the TPP enzyme family. (579 aa)
ABD31832.1D-lactate dehydrogenase, putative; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (315 aa)
mqoMalate:quinone-oxidoreductase. (492 aa)
ABD31480.1Conserved hypothetical protein. (282 aa)
ABD31404.1Conserved hypothetical protein. (397 aa)
ABD31394.1Aldehyde dehydrogenase, putative. (475 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (509 aa)
aldH1Aldehyde dehydrogenase, putative; Involved in the biosynthesis of the yellow-orange carotenoid staphyloxanthin, which plays a role in the virulence via its protective function against oxidative stress. Catalyzes the oxidation of 4,4'- diaponeurosporen-4-al to yield 4,4'-diaponeurosporenoic acid. Belongs to the aldehyde dehydrogenase family. (459 aa)
ABD31054.1Conserved hypothetical protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (316 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa)
ABD30970.1Conserved hypothetical protein. (277 aa)
ABD30939.1Conserved hypothetical protein. (103 aa)
ABD30913.1acetyl-CoA synthetase, putative. (568 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ABD30878.1NADP-dependent malic enzyme, putative. (409 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (285 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
ABD30784.1acetyl-CoA carboxylase, biotin carboxyl carrier protein, putative. (149 aa)
ABD30783.1acetyl-CoA carboxylase, biotin carboxylase, putative. (453 aa)
ABD30720.1Conserved hypothetical protein. (207 aa)
ABD30702.1acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa)
ABD30701.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa)
ABD30693.1Dihydrolipoamide dehydrogenase. (473 aa)
ABD30683.1Conserved hypothetical protein. (123 aa)
acyPAcylphosphatase. (89 aa)
ABD30368.1Conserved hypothetical protein. (288 aa)
ABD30367.1Conserved hypothetical protein. (586 aa)
ABD30181.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1150 aa)
ABD30163.1Dihydrolipoamide dehydrogenase. (468 aa)
ABD30162.1Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex E2, putative. (430 aa)
ABD30161.1Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit, putative. (325 aa)
pdhAPyruvate dehydrogenase complex, E1 component, alpha subunit, putative; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa)
ABD30039.12-isopropylmalate synthase, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. (381 aa)
ABD29845.1Conserved hypothetical protein. (279 aa)
ABD29723.1Conserved hypothetical protein. (440 aa)
ABD29717.1Phosphate acetyltransferase. (328 aa)
ABD29705.1acetyl-CoA acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family. (379 aa)
hchAConserved hypothetical protein; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminocarbino [...] (292 aa)
ABD29495.1Conserved hypothetical protein. (560 aa)
ABD29494.1Conserved hypothetical protein; Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact. Belongs to the DyP-type peroxidase family. (409 aa)
ldh1L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate (Potential). Appears to be the primary factor that allows S.aureus growth during nitrosative stress in both aerobically and anaerobically cultured cells (By similarity). (269 aa)
ABD29377.1Conserved hypothetical protein; Belongs to the 3-oxoacid CoA-transferase family. (525 aa)
aldAAldehyde dehydrogenase, putative. (495 aa)
ABD29294.1Alcohol dehydrogenase, iron-containing, putative; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. (869 aa)
ABD29225.1Conserved hypothetical protein. (444 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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