STRINGSTRING
ABD29322.1 ABD29322.1 drp35 drp35 arcC2 arcC2 ABD31952.1 ABD31952.1 ABD31924.1 ABD31924.1 mqo-2 mqo-2 fda fda ABD31841.1 ABD31841.1 ABD31840.1 ABD31840.1 ABD31810.1 ABD31810.1 gpmA gpmA mqo mqo rpiA rpiA ABD31609.1 ABD31609.1 ABD31600.1 ABD31600.1 ABD31593.1 ABD31593.1 ABD31404.1 ABD31404.1 ABD31397.1 ABD31397.1 glyA glyA ilvA ilvA ABD31236.1 ABD31236.1 ABD31191.1 ABD31191.1 fumC fumC pckA pckA ABD30964.1 ABD30964.1 ABD30913.1 ABD30913.1 fhs fhs ABD30901.1 ABD30901.1 ackA ackA ABD30878.1 ABD30878.1 accD accD accA accA pfkA pfkA pyk pyk ABD30870.1 ABD30870.1 ABD30869.1 ABD30869.1 ABD30862.1 ABD30862.1 ABD30784.1 ABD30784.1 ABD30783.1 ABD30783.1 ABD30722.1 ABD30722.1 gcvT gcvT gcvPA gcvPA gcvPB gcvPB ABD30702.1 ABD30702.1 ABD30701.1 ABD30701.1 ABD30693.1 ABD30693.1 ABD30684.1 ABD30684.1 zwf zwf ABD30587.1 ABD30587.1 tdcB tdcB odhA odhA odhB odhB ABD30443.1 ABD30443.1 ABD30434.1 ABD30434.1 katA katA ABD30368.1 ABD30368.1 ABD30367.1 ABD30367.1 sucD sucD sucC sucC ABD30296.1 ABD30296.1 arcC1 arcC1 ABD30219.1 ABD30219.1 ABD30218.1 ABD30218.1 ABD30217.1 ABD30217.1 ABD30181.1 ABD30181.1 ABD30163.1 ABD30163.1 ABD30162.1 ABD30162.1 ABD30161.1 ABD30161.1 pdhA pdhA folD folD spxA spxA pgi pgi ABD30017.1 ABD30017.1 gcvH gcvH ABD29961.1 ABD29961.1 eno eno gpmI gpmI tpiA tpiA pgk pgk ABD29923.1 ABD29923.1 ABD29723.1 ABD29723.1 ABD29717.1 ABD29717.1 ABD29705.1 ABD29705.1 ABD29701.1 ABD29701.1 ABD29700.1 ABD29700.1 ABD29659.1 ABD29659.1 ABD29641.1 ABD29641.1 ABD29636.1 ABD29636.1 prs prs ABD29526.1 ABD29526.1 ABD29495.1 ABD29495.1 ABD29474.1 ABD29474.1 ABD29466.1 ABD29466.1 ABD29374.1 ABD29374.1 ABD29339.1 ABD29339.1
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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ABD29322.1Formate dehydrogenase, NAD-dependent, putative; Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms. Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily. (341 aa)
drp35Drp35; Exhibits lactonase activity. Acts in cells with perturbed membrane integrity and is possibly related to the membrane homeostasis (By similarity). (323 aa)
arcC2Carbamate kinase. (313 aa)
ABD31952.1Tributyrin esterase, putative. (253 aa)
ABD31924.1acetyl-CoA synthetase, putative. (532 aa)
mqo-2Malate:quinone-oxidoreductase. (498 aa)
fdaFructose-bisphosphate aldolase class-I, putative. (296 aa)
ABD31841.1L-serine dehydratase, iron-sulfur-dependent, beta subunit. (226 aa)
ABD31840.1L-serine dehydratase, iron-sulfur-dependent, alpha subunit. (299 aa)
ABD31810.1Gluconate kinase; Belongs to the FGGY kinase family. (517 aa)
gpmAPhosphoglycerate mutase, putative; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (228 aa)
mqoMalate:quinone-oxidoreductase. (492 aa)
rpiARibose 5-phosphate isomerase, putative; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (228 aa)
ABD31609.1Hex regulon repressor, putative. (254 aa)
ABD31600.1Conserved hypothetical protein. (290 aa)
ABD31593.1Formate dehydrogenase, alpha subunit, putative; In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (984 aa)
ABD31404.1Conserved hypothetical protein. (397 aa)
ABD31397.1Conserved hypothetical protein. (286 aa)
glyASerine hydroxymethyltransferase, putative; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa)
ilvAThereonine dehydratase, putative; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). (422 aa)
ABD31236.1Prohead protease. (194 aa)
ABD31191.1Conserved hypothetical protein; Belongs to the cycloisomerase 2 family. (342 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
pckAPhosphoenolpyruvate carboxykinase (ATP); Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (530 aa)
ABD30964.1Conserved hypothetical protein. (237 aa)
ABD30913.1acetyl-CoA synthetase, putative. (568 aa)
fhsFormate-tetrahydrofolate ligase, putative; Belongs to the formate--tetrahydrofolate ligase family. (555 aa)
ABD30901.1D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (534 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
ABD30878.1NADP-dependent malic enzyme, putative. (409 aa)
accDacetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (285 aa)
accAacetyl-CoA carboxylase, carboxyl transferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (314 aa)
pfkA6-phosphofructokinase, putative; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (307 aa)
pykPyruvate kinase; Belongs to the pyruvate kinase family. (585 aa)
ABD30870.1Conserved hypothetical protein; Belongs to the citrate synthase family. (285 aa)
ABD30869.1Isocitrate dehydrogenase, NADP-dependent. (422 aa)
ABD30862.1Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (341 aa)
ABD30784.1acetyl-CoA carboxylase, biotin carboxyl carrier protein, putative. (149 aa)
ABD30783.1acetyl-CoA carboxylase, biotin carboxylase, putative. (453 aa)
ABD30722.1Glucokinase, putative. (328 aa)
gcvTGlycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. (363 aa)
gcvPAGlycine cleavage system P-protein subunit I, putative; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. (448 aa)
gcvPBGlycine cleavage system P-protein subunit ll, putative; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. C-terminal subunit subfamily. (490 aa)
ABD30702.1acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa)
ABD30701.1acetyl-CoA carboxylase, biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (451 aa)
ABD30693.1Dihydrolipoamide dehydrogenase. (473 aa)
ABD30684.16-phosphogluconate dehydrogenase, decarboxylating; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (468 aa)
zwfGlucose-6-phosphate 1-dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (494 aa)
ABD30587.1Conserved hypothetical protein. (317 aa)
tdcBThreonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity). Belongs to the serine/thre [...] (346 aa)
odhA2-oxoglutarate dehydrogenase, E1 component; E1 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the decarboxylation of 2-oxoglutarate, the first step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2). (932 aa)
odhB2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (422 aa)
ABD30443.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
ABD30434.1Transketolase; Belongs to the transketolase family. (625 aa)
katACatalase; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Involved in resistance to paraquat when fur is absent and to tert-butyl hydroperoxide. Is important for survival under glucose starvation and desiccation conditions. Not required for virulence although is necessary for nasal colonization. (473 aa)
ABD30368.1Conserved hypothetical protein. (288 aa)
ABD30367.1Conserved hypothetical protein. (586 aa)
sucDsuccinyl-CoA synthetase, alpha subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (302 aa)
sucCsuccinyl-CoA synthetase, beta subunit, putative; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (388 aa)
ABD30296.1Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (214 aa)
arcC1Carbamate kinase. (310 aa)
ABD30219.1Iron-sulphur subunit of succinate dehydrogenase, putative. (271 aa)
ABD30218.1Succinate dehydrogenase, flavoprotein chain TC0881, putative. (588 aa)
ABD30217.1Succinate dehydrogenase cytochrome b-558 subunit, putative. (204 aa)
ABD30181.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1150 aa)
ABD30163.1Dihydrolipoamide dehydrogenase. (468 aa)
ABD30162.1Dihydrolipoamide S-acetyltransferase component of pyruvate dehydrogenase complex E2, putative. (430 aa)
ABD30161.1Pyruvate dehydrogenase complex, E1 component, pyruvate dehydrogenase beta subunit, putative. (325 aa)
pdhAPyruvate dehydrogenase complex, E1 component, alpha subunit, putative; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (370 aa)
folDFolD bifunctional protein, putative; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (286 aa)
spxAConserved hypothetical protein; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (131 aa)
pgiGlucose-6-phosphate isomerase. (443 aa)
ABD30017.1Conserved hypothetical protein. (114 aa)
gcvHGlycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (126 aa)
ABD29961.1Conserved hypothetical protein; Belongs to the ArsC family. (118 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (434 aa)
gpmIPhosphoglycerate mutase, 2,3-bisphosphoglycerate-independent; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (505 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa)
pgkPhosphoglycerate kinase, putative; Belongs to the phosphoglycerate kinase family. (396 aa)
ABD29923.1Glyceraldehyde-3-phosphate dehydrogenase, type I; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
ABD29723.1Conserved hypothetical protein. (440 aa)
ABD29717.1Phosphate acetyltransferase. (328 aa)
ABD29705.1acetyl-CoA acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family. (379 aa)
ABD29701.1SIS domain protein. (167 aa)
ABD29700.1Conserved hypothetical protein; Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate. (210 aa)
ABD29659.1Serine acetyltransferase, putative. (215 aa)
ABD29641.1Conserved hypothetical protein; Belongs to the cysteine synthase/cystathionine beta- synthase family. (310 aa)
ABD29636.1S1 RNA binding domain protein. (133 aa)
prsRibose-phosphate pyrophosphokinase, putative; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (321 aa)
ABD29526.1Phosphoglycerate mutase family protein; Belongs to the phosphoglycerate mutase family. (193 aa)
ABD29495.1Conserved hypothetical protein. (560 aa)
ABD29474.1Conserved hypothetical protein. (90 aa)
ABD29466.1Conserved hypothetical protein. (266 aa)
ABD29374.1Conserved hypothetical protein; Belongs to the enoyl-CoA hydratase/isomerase family. (753 aa)
ABD29339.1Conserved hypothetical protein. (291 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
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