STRINGSTRING
asd asd ABD30039.1 ABD30039.1 ABD29684.1 ABD29684.1 ABD29647.1 ABD29647.1 ABD29598.1 ABD29598.1 ABD30870.1 ABD30870.1 ABD30869.1 ABD30869.1 ABD31206.1 ABD31206.1 ilvD ilvD ABD31320.1 ABD31320.1 ABD31321.1 ABD31321.1 ilvC ilvC leuA leuA leuB leuB leuC leuC leuD leuD ABD31488.1 ABD31488.1 ABD31882.1 ABD31882.1 ABD29409.1 ABD29409.1 argC argC argJ argJ argB argB ABD29278.1 ABD29278.1 norG norG ABD30355.1 ABD30355.1 ABD30417.1 ABD30417.1 ABD30443.1 ABD30443.1 ABD30488.1 ABD30488.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa)
ABD30039.12-isopropylmalate synthase, putative; Belongs to the alpha-IPM synthase/homocitrate synthase family. (381 aa)
ABD29684.1Branched-chain amino acid aminotransferase. (358 aa)
ABD29647.1Conserved hypothetical protein. (460 aa)
ABD29598.1Conserved hypothetical protein. (242 aa)
ABD30870.1Conserved hypothetical protein; Belongs to the citrate synthase family. (285 aa)
ABD30869.1Isocitrate dehydrogenase, NADP-dependent. (422 aa)
ABD31206.1Conserved hypothetical protein. (428 aa)
ilvDDihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (562 aa)
ABD31320.1Acetolactate synthase, large subunit, biosynthetic type. (589 aa)
ABD31321.1Conserved hypothetical protein. (84 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (334 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (509 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (348 aa)
leuC3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (456 aa)
leuD3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (190 aa)
ABD31488.1Acetolactate synthase, putative; Belongs to the TPP enzyme family. (554 aa)
ABD31882.1Conserved hypothetical protein. (162 aa)
ABD29409.1Conserved hypothetical protein. (234 aa)
argCN-acetylglutamate gamma-semialdehyde dehydrogenase, putative; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (343 aa)
argJGlutamate N-acetyltransferase/amino-acid acetyltransferase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (413 aa)
argBAcetylglutamate kinase, putative; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (254 aa)
ABD29278.1Transcriptional regulator, GntR family, putative. (251 aa)
norGConserved hypothetical protein; Positively regulates the expression of the NorB efflux pump and negatively regulates the expression of the AbcA efflux pump. Binds specifically to the promoters of norA, norB and norC and abcA genes. Overexpression of norG leads to an increase in the level of resistance to quinolones, associated with a threefold increase in norB transcripts. Disruption of norG leads to an increase in the level of resistance to methicillin, cefotaxime, penicillin G, and nafcillin, associated with a threefold increase in abcA transcripts. Could also have an aminotransferas [...] (465 aa)
ABD30355.1Conserved hypothetical protein. (237 aa)
ABD30417.1Aspartate kinase, putative; Belongs to the aspartokinase family. (460 aa)
ABD30443.1Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (901 aa)
ABD30488.1Aspartokinase II, putative; Belongs to the aspartokinase family. (401 aa)
Your Current Organism:
Staphylococcus aureus
NCBI taxonomy Id: 93061
Other names: S. aureus subsp. aureus NCTC 8325, Staphylococcus aureus NCTC 8325, Staphylococcus aureus subsp. aureus NCTC 8325, Staphylococcus aureus subsp. aureus str. NCTC 8325, Staphylococcus aureus subsp. aureus strain NCTC 8325
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.