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| | ABD31864.1 | Conserved hypothetical protein. (75 aa) |
| | ABD31865.1 | Conserved hypothetical protein. (822 aa) |
| | copZ | Cation-transporting ATPase, E1-E2 family, putative; Chaperone that serves for the intracellular sequestration and transport of Cu(+). Delivers Cu(+) to the copper-exporting P-type ATPase A (CopA) (By similarity). (68 aa) |
| | ssaA | LysM domain protein; Not known; immunogenic protein. (255 aa) |
| | ABD31937.1 | Citrate transporter, putative. (456 aa) |
| | ABD31944.1 | Permease, putative domain protein. (666 aa) |
| | ABD31945.1 | ABC transporter, ATP-binding protein, putative. (251 aa) |
| | ABD31946.1 | Sensor histidine kinase, putative. (295 aa) |
| | ABD31947.1 | DNA-binding response regulator, putative. (221 aa) |
| | ABD31949.1 | Alkaline phosphatase III precursor, putative; Belongs to the alkaline phosphatase family. (474 aa) |
| | arcR | Conserved hypothetical protein; Positively regulates the expression of the arcABDCR operon under anaerobic conditions, by binding to the consensus motif 5'- TGTGAN(6)TCACA-3', thus playing an essential role in arginine catabolism. May also control the expression of genes encoding proteins which are involved in anaerobic metabolism. Can bind cyclic AMP. (234 aa) |
| | isaB | Conserved hypothetical protein; Belongs to the IsaB family. (175 aa) |
| | ABD31967.1 | Conserved hypothetical protein; In the N-terminal section; belongs to the N-acetylmuramoyl- L-alanine amidase 2 family. (619 aa) |
| | ABD31985.1 | Capsular polysaccharide biosynthesis protein, Cap5C. (255 aa) |
| | ABD31986.1 | Capsular polysaccharide biosynthesis protein Cap5B. (230 aa) |
| | ABD31987.1 | Capsular polysaccharide biosynthesis, capA, putative. (220 aa) |
| | ABD32006.1 | Conserved hypothetical protein. (184 aa) |
| | ABD32015.1 | Sodium, sulfate symporter, putative. (472 aa) |
| | ABD32021.1 | ABC transporter, ATP-binding protein, putative. (252 aa) |
| | ABD32022.1 | Permease, putative. (626 aa) |
| | mnmG | Glucose inhibited division protein A, putative; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (594 aa) |
| | mnmE | tRNA modification GTPase TrmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (459 aa) |
| | ptpA | Conserved hypothetical protein; Secreted tyrosine phosphatase that plays a critical role during infection as a bacterial effector protein that counteracts host defenses. Required for intramacrophage survival. (154 aa) |
| | vraR | DNA-binding response regulator VraR, putative; Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. Upon cellular stress, the histidine kinase VraS transfers the phosphoryl group onto VraR. Upon phosphorylation, VraR dimerizes at the N-terminal domain. In turn, phosphorylation-induced dimerization expand and enhance the VraR binding to its own promoter leading to increased expression and subsequent modulation of as many as 40 genes, which ultimately constitute the S.aureus response to cell wall damage. In addition, [...] (209 aa) |
| | ABD31149.1 | Histidine kinase, putative. (347 aa) |
| | ABD31150.1 | Conserved hypothetical protein. (233 aa) |
| | dinB | ImpB/MucB/SamB family superfamily; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (346 aa) |
| | putP | Proline uptake protein; Catalyzes the sodium-dependent uptake of extracellular L- proline (By similarity). Since most S.aureus strains are L-proline auxotrophs, this transporter may aid the bacterial persistence during an infection of tissues with low proline concentrations; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (512 aa) |
| | sdcS | Sodium-dependent transporter (huNaDC-1), putative; Mediates the transport of the dicarboxylates fumarate, malate, and succinate across the cytoplasmic membrane via a Na(+)- electrochemical gradient; Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. (520 aa) |
| | ABD31195.1 | Conserved hypothetical protein. (280 aa) |
| | ABD31196.1 | Conserved hypothetical protein. (160 aa) |
| | ABD31200.1 | ABC transporter, ATP-binding protein, putative. (290 aa) |
| | ABD31295.1 | Abortive infection protein. (247 aa) |
| | agrB | Accessory gene regulator protein B; Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP; Belongs to the AgrB family. (189 aa) |
| | ABD31302.1 | Accessory gene regulator protein C. (414 aa) |
| | ABD31303.1 | Accessory gene regulator protein A. (208 aa) |
| | ABD31308.1 | Ammonium transporter. (416 aa) |
| | ABD31331.1 | S1 RNA binding domain protein. (716 aa) |
| | ABD31332.1 | Sigma factor B, putative; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (256 aa) |
| | ABD31335.1 | sigmaB regulation protein RsbU, putative. (262 aa) |
| | ABD31336.1 | sigmaB regulation protein RsbU, putative. (96 aa) |
| | kdpC | Potassium-transporting ATPase, C subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP-binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB/KdpC/ATP ternary complex. (186 aa) |
| | kdpB | Potassium-translocating P-type ATPase, B subunit, putative; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily. (657 aa) |
| | kdpA | Potassium-transporting ATPase, A subunit; Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane. (558 aa) |
| | kdpD | Sensor protein KdpD, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide production. May function as a membrane-associated protein kinase that phosphorylates KdpE in response to environmental signals. In turn, KpdE functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. (885 aa) |
| | kdpE | DNA-binding response regulator, putative; Member of the two-component regulatory system KdpD/KdpE that regulates the transcription of a series of virulence factors through sensing external K(+) concentrations. Regulates also capsular polysaccharide synthesis. Upon phosphorylation by KpdD, functions as a transcriptional regulator by direct binding to promoter regions of target genes including spa, hla, aur and geh. Represses the transcription of kdpFABC operon. (231 aa) |
| | ABD31383.1 | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (375 aa) |
| | ptpB | Conserved hypothetical protein; Dephosphorylates the phosphotyrosine-containing proteins. Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (139 aa) |
| | ABD31388.1 | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (365 aa) |
| | ABD31442.1 | Conserved hypothetical protein; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (295 aa) |
| | ABD31582.1 | Conserved hypothetical protein. (651 aa) |
| | ssaA2 | Secretory antigen precursor, putative; Not known; immunogenic protein. (267 aa) |
| | ABD31588.1 | Secretory antigen precursor SsaA, putative. (166 aa) |
| | ABD31598.1 | Conserved hypothetical protein. (245 aa) |
| | lyrA | Conserved hypothetical protein; Belongs to the LyrA family. (419 aa) |
| | ABD31627.1 | Conserved hypothetical protein. (410 aa) |
| | hssR | DNA-binding response regulator, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. Phosphorylated HssR binds to a direct repeat sequence within hrtAB promoter and activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (224 aa) |
| | hssS | Sensor histidine kinase, putative; Member of the two-component regulatory system HssS/HssR involved in intracellular heme homeostasis and tempering of staphylococcal virulence. HssS functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to an aspartate residue of HssR. HssR/HssS activates the expression of hrtAB, an efflux pump, in response to extracellular heme, hemin, hemoglobin or blood (By similarity). (457 aa) |
| | ABD31653.1 | Conserved hypothetical protein. (147 aa) |
| | ABD31672.1 | Transcriptional regulator, putative. (701 aa) |
| | ABD31675.1 | Conserved hypothetical protein; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. (425 aa) |
| | narT | Conserved hypothetical protein; Probably required for nitrate uptake under anoxic conditions. Also possibly involved in excretion of nitrite produced by the dissimilatory reduction of nitrate (By similarity). (389 aa) |
| | nreC | Conserved hypothetical protein; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. Phosphorylated NreC binds to a GC-rich palindromic sequence at the promoters of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT, and activates their expression (By similarity). (200 aa) |
| | nreB | Conserved hypothetical protein; Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT (By similarity). (344 aa) |
| | ABD31685.1 | Conserved hypothetical protein. (150 aa) |
| | ABD31686.1 | Respiratory nitrate reductase, gamma subunit. (225 aa) |
| | ABD31687.1 | Respiratory nitrate reductase, delta subunit, putative. (196 aa) |
| | ABD31688.1 | Nitrate reductase, beta subunit. (481 aa) |
| | ABD31689.1 | Nitrate reductase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1229 aa) |
| | ABD31759.1 | Conserved hypothetical protein. (358 aa) |
| | ABD31765.1 | Conserved hypothetical protein. (249 aa) |
| | ABD31811.1 | Gluconate operon transcriptional repressor, putative. (226 aa) |
| | ABD31817.1 | Conserved hypothetical protein. (425 aa) |
| | ABD31818.1 | Conserved hypothetical protein. (203 aa) |
| | ABD31822.1 | Conserved hypothetical protein. (231 aa) |
| | ABD31844.1 | Conserved hypothetical protein. (311 aa) |
| | cidB | Conserved hypothetical protein; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypoth [...] (229 aa) |
| | cidA | Conserved hypothetical protein; Increases the activity of extracellular murein hydrolases possibly by mediating their export via hole formation. Inhibited by the antiholin-like proteins LrgAB. In an unstressed cell, the LrgAB products probably inhibit the function of the CidAB proteins. When a cell is stressed by the addition of antibiotics or by other factors in the environment, the CidAB proteins possibly oligomerize within the bacterial cell membrane, creating lesions that disrupt the proton motive force, which in turn results in loss of cell viability. These lesions are also hypoth [...] (131 aa) |
| | ABD31854.1 | LysM domain protein. (143 aa) |
| | ABD31039.1 | DNA-binding response regulator, putative. (207 aa) |
| | ABD31027.1 | ABC transporter, ATP-binding protein, putative. (246 aa) |
| | ABD31013.1 | Lantibiotic epidermin biosynthesis protein EpiB, putative. (997 aa) |
| | ABD31012.1 | Epidermin biosynthesis protein EpiC, authentic point mutation. (414 aa) |
| | ABD31010.1 | Intracellular serine protease, putative; Belongs to the peptidase S8 family. (457 aa) |
| | ABD31009.1 | ABC transporter domain protein. (230 aa) |
| | ABD31008.1 | Membrane protein, putative. (253 aa) |
| | ABD31007.1 | Membrane protein, putative. (232 aa) |
| | ABD30996.1 | Type I restriction-modification system, M subunit. (579 aa) |
| | ABD30963.1 | Conserved hypothetical protein. (211 aa) |
| | sigS | Conserved hypothetical protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival. (156 aa) |
| | arsC | Arsenate reductase; Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)]. (131 aa) |
| | ABD30927.1 | Conserved hypothetical protein. (358 aa) |
| | ABD30906.1 | Conserved hypothetical protein. (424 aa) |
| | ABD30891.1 | Conserved hypothetical protein. (256 aa) |
| | ABD30878.1 | NADP-dependent malic enzyme, putative. (409 aa) |
| | ABD30868.1 | Two-component response regulator, putative. (234 aa) |
| | ABD30867.1 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. (553 aa) |
| | srrA | DNA-binding response regulator, putative; Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation. Plays also an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate (By similarity). Functions as a transcription regulator by direct binding to promoter regions of target genes (By similarity). (241 aa) |
| | srrB | Staphylococcal respiratory response protein SrrB, putative; Member of the two-component regulatory system SrrA/SrrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels as well as biofilm formation. Plays also an essential role in host-derived nitric oxide resistance by regulating hmp/flavohemoglobin, an enzyme that detoxifies nitric oxide by converting it to nitrate. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to SrrA. In turn, SrrA binds [...] (583 aa) |
| | ABD30662.1 | Conserved hypothetical phage protein. (675 aa) |
| | ABD30641.1 | Conserved hypothetical phage protein. (85 aa) |
| | ABD30595.1 | Conserved hypothetical protein. (115 aa) |
| | arlR | DNA-binding response regulator, putative; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS/ArlR affects expression of the multidrug resistance transporter NorA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (serine protease), spa (surface protein A) and hla (alpha-hemolysin). Could inhibit biofilm development by a mechanism independent of the [...] (219 aa) |
| | arlS | Conserved hypothetical protein; Member of the two-component regulatory system ArlS/ArlR involved in the regulation of adhesion, autolysis, multidrug resistance and virulence. ArlS probably functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to ArlR. ArlS/ArlR affects expression of the multidrug resistance transporter norA and interacts with both Agr (virulence accessory gene regulator) (negatively) and SarA (staphylococcal accessory regulator) (positively) to modulate several virulence factor genes, including ssp (se [...] (451 aa) |
| | pstS | Phosphate ABC transporter, periplasmic phosphate-binding protein, putative; Part of the ABC transporter complex PstSACB involved in phosphate import. (327 aa) |
| | ABD30460.1 | Conserved hypothetical protein. (343 aa) |
| | ABD30458.1 | Conserved hypothetical protein; Belongs to the DNA polymerase type-Y family. (420 aa) |
| | mprF | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively [...] (840 aa) |
| | ABD30450.1 | Sodium:alanine symporter family protein, putative. (486 aa) |
| | ABD30412.1 | Conserved hypothetical protein. (200 aa) |
| | ABD30411.1 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase domain protein. (363 aa) |
| | ABD30386.1 | Glutamine synthetase, type I. (446 aa) |
| | ABD30360.1 | Conserved hypothetical protein. (130 aa) |
| | infB | Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (705 aa) |
| | ABD30241.1 | Conserved hypothetical protein. (496 aa) |
| | ctaA | Heme A synthase, putative; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 1 subfamily. (356 aa) |
| | ABD30153.1 | Cytochrome d ubiquinol oxidase, subunit II, putative. (339 aa) |
| | ABD30152.1 | Cytochrome d ubiquinol oxidase, subunit I, putative. (453 aa) |
| | ABD30083.1 | Serine protease HtrA, putative. (774 aa) |
| | ABD30074.1 | Conserved hypothetical protein. (522 aa) |
| | ABD30064.1 | Conserved hypothetical protein. (105 aa) |
| | ABD30040.1 | Conserved hypothetical protein; Belongs to the SUA5 family. (213 aa) |
| | ABD30015.1 | Conserved hypothetical protein. (127 aa) |
| | dltD | Extramembranal protein; Involved in the D-alanylation of lipoteichoic acid (LTA). Could be responsible for the transfer of DltC-carried D-alanyl groups to cell membrane phosphatidylglycerol (PG), or alternatively of D- alanine residues from D-Ala-undecaprenol phosphate to the poly(glycerophosphate) chains of LTA. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram- positive bacteria, influencing the net charge of the cell wall. (391 aa) |
| | dltC | D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (78 aa) |
| | ABD29995.1 | dltB protein, putative; Could be involved in the transport of activated D-alanine through the membrane. (404 aa) |
| | dltA | D-alanine-activating enzyme; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs to the ATP-dependent AMP [...] (485 aa) |
| | ABD29984.1 | Conserved hypothetical protein. (275 aa) |
| | ABD29903.1 | LysM domain protein; Has weak lytic activity toward S.aureus cells. (279 aa) |
| | ABD29892.1 | Conserved hypothetical protein. (356 aa) |
| | ABD29873.1 | Conserved hypothetical protein. (244 aa) |
| | saeR | Response regulator, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs near the promoter sequences of target genes. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (Hla, Hlb), Coa, DNase, Spa and cell wall- associated proteins (Emp, Eap, FnbA). Acts probably downstream of the Agr system in the regulatory c [...] (228 aa) |
| | saeS | Sensor histidine kinase SaeS, putative; Member of the two-component regulatory system SaeR/SaeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane-associated protein kinase that upon sensing the appropriate signal, autophosphorylates and in turn activates the cytosolic response regulator SaeR. SaeR/SaeS activates the expression of exoproteins involved in adhesion and invasion of host cells, including hemolysins (hla, hlb), coa, Dnase, spa and cell wall-associated proteins (emp, eap, fnbA). Acts probably downstr [...] (351 aa) |
| | ABD29832.1 | Deoxyribodipyrimidine photolyase, putative; Belongs to the DNA photolyase family. (457 aa) |
| | ABD29831.1 | Conserved hypothetical protein. (517 aa) |
| | ABD29806.1 | Conserved hypothetical protein. (716 aa) |
| | ABD29804.1 | Secretory antigen SsaA-like protein; Has weak lytic activity toward S.aureus cells. (265 aa) |
| | ABD29801.1 | ABC transporter permease, putative. (629 aa) |
| | ABD29800.1 | ABC transporter ATP-binding protein, putative. (253 aa) |
| | graS | Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which phosphorylates GraR through the auxiliary protein GraX. In turn, GraR up-regulates many genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. Confers resistance to vancomycin, polymyxin B, lysozyme and LL-37. (346 aa) |
| | graR | Conserved hypothetical protein; Member of the two-component regulatory system GraR/GraS involved in resistance against cationic antimicrobial peptides (CAMPs). Upon phosphorylation by GraS, functions as a transcription regulator by direct binding to promoter regions of target genes such as adhesins, exoproteins, transporters, toxins, and proteins involved in cell wall synthesis. Down-regulates the expression of many genes involved in RNA and amino acid synthesis or glycolysis. (224 aa) |
| | ABD29705.1 | acetyl-CoA acetyltransferase, putative; Belongs to the thiolase-like superfamily. Thiolase family. (379 aa) |
| | ABD29664.1 | Conserved hypothetical protein; Belongs to the sigma-70 factor family. ECF subfamily. (189 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (444 aa) |
| | sle1 | Autolysin precursor, putative; Peptidoglycan hydrolase involved in the splitting of the septum during cell division. Binds to both alpha and beta-chains of human fibrinogen as well as fibronectin, which suggests a role in the colonization of host factor-coated material or host tissue. Also exhibits lytic activity against S.carnosus and S.aureus cells but not against M.luteus cells. (334 aa) |
| | ABD29560.1 | Type I restriction-modification system, M subunit. (490 aa) |
| | ABD29537.1 | Conserved hypothetical protein. (135 aa) |
| | ABD29486.1 | Glycerol-3-phosphate transporter. (452 aa) |
| | ABD29463.1 | Conserved hypothetical protein; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (510 aa) |
| | ABD29430.1 | Conserved hypothetical protein. (297 aa) |
| | ABD29421.1 | Drug transporter, putative. (458 aa) |
| | lrgB | Holin-like protein LrgB, putative; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. Increases tolerance to penicillin possibly by inhibiting the formation of the CidAB holin-like complexes within the membrane, thus reducing penicillin-induced lethality. Possibly plays a role in programmed cell death (PCD), triggering PCD in response to penicillin, and possibly other antibiotics, and environmental stresses. (233 aa) |
| | lrgA | Conserved hypothetical protein; Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgB, with the holin-like proteins CidA and/or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. Increases tolerance to penicillin possibly by inhibiting the formation of the CidAB holin-like complexes within the membrane, thus reducing penicillin-induced lethality. Possibly plays a role in programmed cell death (PCD), triggering PCD in response to penicillin, and possibly other antibiotics, and environmental stresses. (147 aa) |
| | lytR | Two-component response regulator, putative; Member of the two-component regulatory system LytR/LytS that regulates genes involved in autolysis, programmed cell death, biofilm formation and cell wall metabolism. Participates also in sensing and responding to host defense cationic antimicrobial peptides (HDPs). Upon phosphorylation by LytS, functions as a transcription regulator by direct binding to promoter regions of target genes including lrgA and lrgB, to positively regulate their expression. (246 aa) |
| | lytS | Two-component sensor histidine kinase, putative; Member of the two-component regulatory system LytR/LytS that regulates genes involved in autolysis, programmed cell death, biofilm formation and cell wall metabolism. Participates also in sensing and responding to host defense cationic antimicrobial peptides (CAMPs). Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of LytR. In turn, LytR binds to the upstream promoter regions of target genes including l [...] (579 aa) |
| | hptS | Conserved hypothetical protein; Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources. May act as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of HptS. In turn, HptS antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility. (518 aa) |
| | hptR | Response regulator receiver domain protein; Member of the two-component regulatory system HptS/HptR that regulates genes involved in hexose phosphate transport system in response to changes in extracellular phosphate sources. Activates uhpT expression to facilitate glucose-6- phosphate/G6P utilization by directly binding to its promoter. Antagonizes CcpA-dependent transcription of a subset of CcpA-regulated genes involved in antibiotic susceptibility. (252 aa) |
| | ABD29361.1 | Membrane protein, putative. (459 aa) |
| | ABD29310.1 | UDP-N-acetylglucosamine 2-epimerase; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (381 aa) |
| | ABD29297.1 | Capsular polysaccharide synthesis enzyme Cap8C. (254 aa) |
| | ABD29296.1 | Capsular polysaccharide synthesis enzyme Cap5B. (228 aa) |
| | ABD29295.1 | Capsular polysaccharide biosynthesis protein, putative. (222 aa) |
| | ABD29249.1 | Conserved hypothetical protein. (290 aa) |
| | ABD29246.1 | Conserved hypothetical protein. (462 aa) |
| | ABD29228.1 | Conserved hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (310 aa) |
| | ABD29222.1 | Conserved hypothetical protein. (251 aa) |
| | ABD29220.1 | Conserved hypothetical protein. (150 aa) |
| | walK | Sensory box histidine kinase VicK, putative; Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue in the dimerization domain and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of WalR. In turn, WalR binds to the upstream promoter regions of the target ge [...] (608 aa) |
| | walR | Two-component response regulator, putative; Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins. Functions as a transcription regulator by direct binding to promoter regions. Positively controls the cell wall-hydrolytic activity through regulation of atlA and lytM, as well as induces transcription of isaA, sceD, ssaA, and four ssaA- related genes. Binds directly to the lytM, ssaA and is [...] (233 aa) |
| | dnaA | Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (453 aa) |
| | ABD31040.1 | Sensor histidine kinase, putative. (370 aa) |
