STRINGSTRING
priA priA recF recF gyrB gyrB dnaQ dnaQ APR51663.1 APR51663.1 polA polA APR51706.1 APR51706.1 APR51732.1 APR51732.1 smc smc dnaE2 dnaE2 APR51959.1 APR51959.1 APR51962.1 APR51962.1 APR51984.1 APR51984.1 APR54839.1 APR54839.1 APR52001.1 APR52001.1 APR52008.1 APR52008.1 APR52013.1 APR52013.1 APR52041.1 APR52041.1 APR54846.1 APR54846.1 APR52310.1 APR52310.1 APR52390.1 APR52390.1 APR52519.1 APR52519.1 lexA lexA APR52788.1 APR52788.1 APR52884.1 APR52884.1 dnaX dnaX dnaG dnaG gyrA gyrA APR53382.1 APR53382.1 APR53482.1 APR53482.1 APR53559.1 APR53559.1 APR53570.1 APR53570.1 APR53667.1 APR53667.1 APR53933.1 APR53933.1 ligA-2 ligA-2 dnaA dnaA dnaJ dnaJ APR54274.1 APR54274.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
priAPrimosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (721 aa)
recFDNA replication/repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (353 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (845 aa)
dnaQDNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (230 aa)
APR51663.1DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (921 aa)
APR51706.1ATP-dependent DNA helicase RecQ; Derived by automated computational analysis using gene prediction method: Protein Homology. (589 aa)
APR51732.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (187 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1135 aa)
dnaE2Error-prone DNA polymerase; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1118 aa)
APR51959.1Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (648 aa)
APR51962.1Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (351 aa)
APR51984.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (1101 aa)
APR54839.1DNA primase; Derived by automated computational analysis using gene prediction method: Protein Homology. (915 aa)
APR52001.1Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
APR52008.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (371 aa)
APR52013.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
APR52041.1DNA methylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the N(4)/N(6)-methyltransferase family. (223 aa)
APR54846.1RepA replication protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
APR52310.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (504 aa)
APR52390.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (367 aa)
APR52519.1Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
lexARepressor LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (228 aa)
APR52788.1DNA polymerase III subunit chi; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
APR52884.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
dnaXDNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (537 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (617 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (913 aa)
APR53382.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (287 aa)
APR53482.1Chromosomal replication initiator DnaA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DnaA family. (207 aa)
APR53559.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (767 aa)
APR53570.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1160 aa)
APR53667.1Molecular chaperone DnaJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
APR53933.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
ligA-2DNA ligase (NAD(+)) LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (710 aa)
dnaAChromosomal replication initiation protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (454 aa)
dnaJMolecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...] (372 aa)
APR54274.1Type VI secretion protein ImpB; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
Your Current Organism:
Sphingomonas koreensis
NCBI taxonomy Id: 93064
Other names: DSM 15582, IFO 16723, JCM 11456, KCCM 41069, KCTC 2882, NBRC 16723, S. koreensis, Sphingomonas koreensis Lee et al. 2001, Sphingomonas sp. ABOJT, Sphingomonas sp. ABOJU, Sphingomonas sp. ABOJV, Sphingomonas sp. JSS-26, Sphingomonas sp. JSS-28, Sphingomonas sp. JSS26, Sphingomonas sp. JSS28, strain JSS26
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