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C448_14590 C448_14590 C448_00005 C448_00005 C448_00597 C448_00597 C448_00657 C448_00657 C448_00947 C448_00947 C448_01194 C448_01194 fxsA fxsA C448_03766 C448_03766 C448_03846 C448_03846 ilvE ilvE C448_04504 C448_04504 C448_04724 C448_04724 C448_04729 C448_04729 C448_14869 C448_14869 C448_05206 C448_05206 aksA aksA C448_06118 C448_06118 C448_07182 C448_07182 C448_07257 C448_07257 C448_08569 C448_08569 lysK-2 lysK-2 lysJ lysJ lysZ lysZ argC argC C448_08804 C448_08804 C448_09987 C448_09987 C448_10222 C448_10222 C448_10252 C448_10252 C448_11001 C448_11001 C448_11006 C448_11006 C448_11011 C448_11011 ilvC ilvC leuC leuC C448_11031 C448_11031 C448_11036 C448_11036 C448_11041 C448_11041 C448_11061 C448_11061 C448_11156 C448_11156 C448_11481 C448_11481 C448_12701 C448_12701 C448_12821 C448_12821 C448_12936 C448_12936 C448_13446 C448_13446 C448_13661 C448_13661 C448_13831 C448_13831 C448_14413 C448_14413
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C448_14590(R)-citramalate synthase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (468 aa)
C448_00005Peptidase M50; COG0750 Predicted membrane-associated Zn-dependent proteases 1. (385 aa)
C448_00597Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (551 aa)
C448_006572-methylcitrate synthase/citrate synthase II; COG0372 Citrate synthase. (382 aa)
C448_00947COG1522 Transcriptional regulators. (151 aa)
C448_01194COG1522 Transcriptional regulators. (164 aa)
fxsACOG3030 Protein affecting phage T7 exclusion by the F plasmid. (166 aa)
C448_03766Acetolactate synthase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (531 aa)
C448_03846Aconitate hydratase; COG1048 Aconitase A. (657 aa)
ilvEBranched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (310 aa)
C448_04504Aminotransferase class I and II; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (373 aa)
C448_04724Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (379 aa)
C448_04729Transcriptional regulator, AsnC family protein; COG1522 Transcriptional regulators. (162 aa)
C448_14869Peptidase M20; COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (372 aa)
C448_05206COG0624 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases. (365 aa)
aksACOG0119 Isopropylmalate/homocitrate/citramalate synthases. (362 aa)
C448_06118COG1522 Transcriptional regulators. (137 aa)
C448_07182COG0436 Aspartate/tyrosine/aromatic aminotransferase. (366 aa)
C448_07257COG0115 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (292 aa)
C448_08569COG0527 Aspartokinases; Belongs to the aspartokinase family. (392 aa)
lysK-2Acetyl-lysine deacetylase; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (353 aa)
lysJAcetylornithine aminotransferase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. LysJ subfamily. (378 aa)
lysZAcetylglutamate/acetylaminoadipate kinase; Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis); Belongs to the acetylglutamate kinase family. LysZ subfamily. (277 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Involved in both the arginine and lysine biosynthetic pathways; Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily. (345 aa)
C448_08804Lysine biosynthesis protein LysX; COG0189 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase). (290 aa)
C448_09987COG0456 Acetyltransferases. (165 aa)
C448_10222Sulfoacetaldehyde acetyltransferase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (595 aa)
C448_10252COG1522 Transcriptional regulators. (194 aa)
C448_11001Pyruvate carboxyltransferase; COG0119 Isopropylmalate/homocitrate/citramalate synthases. (350 aa)
C448_11006Acetolactate synthase large subunit; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]. (600 aa)
C448_11011COG0440 Acetolactate synthase, small (regulatory) subunit. (210 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (349 aa)
leuCIsopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa)
C448_11031COG0066 3-isopropylmalate dehydratase small subunit. (203 aa)
C448_11036COG0473 Isocitrate/isopropylmalate dehydrogenase. (162 aa)
C448_11041COG0473 Isocitrate/isopropylmalate dehydrogenase. (76 aa)
C448_11061N-acetyltransferase GCN5; COG1246 N-acetylglutamate synthase and related acetyltransferases. (192 aa)
C448_11156COG0136 Aspartate-semialdehyde dehydrogenase. (343 aa)
C448_11481Hypothetical protein. (232 aa)
C448_12701Thiamine pyrophosphate-dependent enzyme, possible carboligase or decarboxylase; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (566 aa)
C448_12821Hypothetical protein; COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]; Belongs to the TPP enzyme family. (523 aa)
C448_12936Class I and II aminotransferase; COG0436 Aspartate/tyrosine/aromatic aminotransferase. (355 aa)
C448_13446Pab N-terminal acetyltransferase; COG0456 Acetyltransferases. (138 aa)
C448_13661COG0538 Isocitrate dehydrogenases. (417 aa)
C448_13831COG1522 Transcriptional regulators. (142 aa)
C448_14413COG0436 Aspartate/tyrosine/aromatic aminotransferase. (380 aa)
Your Current Organism:
Halococcus morrhuae
NCBI taxonomy Id: 931277
Other names: H. morrhuae DSM 1307, Halococcus morrhuae DSM 1307, Halococcus morrhuae JCM 8876, Halococcus morrhuae NRC 16008
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