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EHB50466.1 EHB50466.1 aroC aroC trpD trpD EHB53580.1 EHB53580.1 EHB56108.1 EHB56108.1 EHB56106.1 EHB56106.1 EHB56101.1 EHB56101.1 pheA pheA pat pat EHB54790.1 EHB54790.1 aroA aroA aroK aroK aroB aroB aroQ aroQ EHB49720.1 EHB49720.1 EHB47717.1 EHB47717.1 EHB45349.1 EHB45349.1 hisC hisC priA-2 priA-2 trpE trpE trpC trpC trpB trpB trpA trpA EHB44037.1 EHB44037.1 EHB58547.1 EHB58547.1 EHB58244.1 EHB58244.1 EHB58180.1 EHB58180.1 trpF trpF
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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Your Input:
EHB50466.1Shikimate-5-dehydrogenase; KEGG: mkm:Mkms_2396 shikimate 5-dehydrogenase; TIGRFAM: Shikimate dehydrogenase, AroM-type; PFAM: Shikimate dehydrogenase substrate binding, N-terminal; Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase; Belongs to the shikimate dehydrogenase family. (266 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (405 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (322 aa)
EHB53580.1Phospho-2-dehydro-3-deoxyheptonate aldolase; TIGRFAM: DAHP synthetase, class II; KEGG: mgi:Mflv_2971 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase, class II; Belongs to the class-II DAHP synthase family. (465 aa)
EHB56108.1Chorismate mutase related enzyme; TIGRFAM: Isochorismate pyruvate-lyase, salicylic acid biosynthesis; PFAM: Chorismate mutase, type II; KEGG: req:REQ_23860 chorismate mutase; SMART: Chorismate mutase. (101 aa)
EHB56106.1PFAM: NAD-dependent epimerase/dehydratase; KEGG: req:REQ_23840 prephenate dehydratase. (307 aa)
EHB56101.1TIGRFAM: Phospho-2-dehydro-3-deoxyheptonate aldolase, subtype 2; KEGG: cag:Cagg_2815 phospho-2-dehydro-3-deoxyheptonate aldolase; PFAM: DAHP synthetase I/KDSA. (343 aa)
pheAKEGG: mjl:Mjls_5415 prephenate dehydratase; PFAM: Prephenate dehydratase; Amino acid-binding ACT. (306 aa)
patHistidinol-phosphate aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (352 aa)
EHB54790.1KEGG: mjl:Mjls_5343 prephenate dehydrogenase; PFAM: Prephenate dehydrogenase. (313 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (428 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (221 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (147 aa)
EHB49720.1KEGG: mmi:MMAR_2329 3-dehydroquinate synthase AroB_2; PFAM: 3-dehydroquinate synthase AroB. (362 aa)
EHB47717.1Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. (189 aa)
EHB45349.1PFAM: Peptidase C26; KEGG: msm:MSMEG_2596 peptidase C26. (246 aa)
hisCPFAM: Aminotransferase, class I/classII; TIGRFAM: Histidinol-phosphate aminotransferase; HAMAP: Histidinol-phosphate aminotransferase; KEGG: mjl:Mjls_3078 histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (377 aa)
priA-21-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. (244 aa)
trpEAnthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (506 aa)
trpCKEGG: mva:Mvan_2816 indole-3-glycerol-phosphate synthase; PFAM: Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (272 aa)
trpBTryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (423 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (270 aa)
EHB44037.1KEGG: mab:MAB_4440c hypothetical protein. (150 aa)
EHB58547.1Septum formation protein Maf; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. (198 aa)
EHB58244.1PFAM: Shikimate dehydrogenase substrate binding, N-terminal; Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase; KEGG: mva:Mvan_4817 shikimate 5-dehydrogenase. (273 aa)
EHB58180.1TIGRFAM: Chorismate mutase, high GC Gram-positive bacteria/archaeal; PFAM: Chorismate mutase, type II; KEGG: mav:MAV_1069 hypothetical protein; SMART: Chorismate mutase. (90 aa)
trpFKEGG: mma:MM_3314 N-(5'-phosphoribosyl)anthranilate isomerase; PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI); Belongs to the TrpF family. (214 aa)
Your Current Organism:
Mycolicibacterium rhodesiae JS60
NCBI taxonomy Id: 931627
Other names: M. rhodesiae JS60, Mycobacterium rhodesiae JS60
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