STRINGSTRING
I6NE69_ERECY I6NE69_ERECY G8JME6_ERECY G8JME6_ERECY G8JMX3_ERECY G8JMX3_ERECY G8JNP3_ERECY G8JNP3_ERECY NTG1 NTG1 G8JP40_ERECY G8JP40_ERECY NBP35 NBP35 G8JQL1_ERECY G8JQL1_ERECY G8JRN2_ERECY G8JRN2_ERECY G8JS34_ERECY G8JS34_ERECY G8JS92_ERECY G8JS92_ERECY G8JSA3_ERECY G8JSA3_ERECY CFD1 CFD1 G8JUS6_ERECY G8JUS6_ERECY G8JVK5_ERECY G8JVK5_ERECY G8JVP5_ERECY G8JVP5_ERECY G8JVU0_ERECY G8JVU0_ERECY G8JW61_ERECY G8JW61_ERECY G8JX59_ERECY G8JX59_ERECY G8JXR5_ERECY G8JXR5_ERECY G8JXV6_ERECY G8JXV6_ERECY I6NCP0_ERECY I6NCP0_ERECY I6NCW0_ERECY I6NCW0_ERECY I6NDM1_ERECY I6NDM1_ERECY DRE2 DRE2 I6NE21_ERECY I6NE21_ERECY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I6NE69_ERECYDNA polymerase. (1092 aa)
G8JME6_ERECYDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2184 aa)
G8JMX3_ERECYUncharacterized protein. (550 aa)
G8JNP3_ERECYDNA polymerase. (1469 aa)
NTG1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (364 aa)
G8JP40_ERECYFlavodoxin-like domain-containing protein. (784 aa)
NBP35Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NB [...] (326 aa)
G8JQL1_ERECYHelicase ATP-binding domain-containing protein. (756 aa)
G8JRN2_ERECY2-(3-amino-3-carboxypropyl)histidine synthase subunit 1; Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2. (427 aa)
G8JS34_ERECYFe-S_biosyn domain-containing protein. (195 aa)
G8JS92_ERECYDNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (509 aa)
G8JSA3_ERECYNfu_N domain-containing protein. (246 aa)
CFD1Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD [...] (280 aa)
G8JUS6_ERECYFe_hyd_lg_C domain-containing protein; Belongs to the NARF family. (465 aa)
G8JVK5_ERECY2-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2; Belongs to the DPH1/DPH2 family. DPH2 subfamily. (571 aa)
G8JVP5_ERECYElongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (557 aa)
G8JVU0_ERECYLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (382 aa)
G8JW61_ERECY3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (780 aa)
G8JX59_ERECYAconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (784 aa)
G8JXR5_ERECYAconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (778 aa)
G8JXV6_ERECYSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (263 aa)
I6NCP0_ERECYElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (656 aa)
I6NCW0_ERECYHomoaconitase, mitochondrial; Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis. (719 aa)
I6NDM1_ERECYDNA polymerase. (1475 aa)
DRE2Fe-S cluster assembly protein DRE2; Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by [...] (330 aa)
I6NE21_ERECYUncharacterized protein. (1497 aa)
Your Current Organism:
Eremothecium cymbalariae
NCBI taxonomy Id: 931890
Other names: E. cymbalariae DBVPG#7215, Eremothecium cymbalariae DBVPG#7215
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.