STRINGSTRING
I6NDL0_ERECY I6NDL0_ERECY I6NDK9_ERECY I6NDK9_ERECY I6NDB5_ERECY I6NDB5_ERECY I6NDB4_ERECY I6NDB4_ERECY I6NDB2_ERECY I6NDB2_ERECY I6ND34_ERECY I6ND34_ERECY I6ND16_ERECY I6ND16_ERECY I6NCQ1_ERECY I6NCQ1_ERECY I6NCP7_ERECY I6NCP7_ERECY I6NCM1_ERECY I6NCM1_ERECY G8JXV0_ERECY G8JXV0_ERECY G8JXQ9_ERECY G8JXQ9_ERECY G8JXL9_ERECY G8JXL9_ERECY G8JX98_ERECY G8JX98_ERECY G8JX42_ERECY G8JX42_ERECY G8JWS6_ERECY G8JWS6_ERECY G8JWR3_ERECY G8JWR3_ERECY G8JWR2_ERECY G8JWR2_ERECY G8JWP5_ERECY G8JWP5_ERECY RRM3 RRM3 G8JW81_ERECY G8JW81_ERECY G8JW66_ERECY G8JW66_ERECY G8JVV0_ERECY G8JVV0_ERECY G8JVP8_ERECY G8JVP8_ERECY PIM1 PIM1 G8JV74_ERECY G8JV74_ERECY G8JUW4_ERECY G8JUW4_ERECY G8JU98_ERECY G8JU98_ERECY G8JTS1_ERECY G8JTS1_ERECY G8JTJ6_ERECY G8JTJ6_ERECY G8JTB6_ERECY G8JTB6_ERECY G8JT78_ERECY G8JT78_ERECY G8JT57_ERECY G8JT57_ERECY G8JT56_ERECY G8JT56_ERECY G8JT29_ERECY G8JT29_ERECY G8JST9_ERECY G8JST9_ERECY G8JSK1_ERECY G8JSK1_ERECY G8JSI9_ERECY G8JSI9_ERECY G8JSI5_ERECY G8JSI5_ERECY G8JSF0_ERECY G8JSF0_ERECY G8JSC3_ERECY G8JSC3_ERECY G8JS92_ERECY G8JS92_ERECY G8JS37_ERECY G8JS37_ERECY G8JRW3_ERECY G8JRW3_ERECY G8JQ32_ERECY G8JQ32_ERECY G8JQ47_ERECY G8JQ47_ERECY G8JQ52_ERECY G8JQ52_ERECY G8JQJ5_ERECY G8JQJ5_ERECY G8JQL3_ERECY G8JQL3_ERECY G8JQR1_ERECY G8JQR1_ERECY G8JQY1_ERECY G8JQY1_ERECY G8JQZ0_ERECY G8JQZ0_ERECY G8JR51_ERECY G8JR51_ERECY G8JR54_ERECY G8JR54_ERECY G8JRQ9_ERECY G8JRQ9_ERECY G8JRR0_ERECY G8JRR0_ERECY G8JRU6_ERECY G8JRU6_ERECY G8JM02_ERECY G8JM02_ERECY G8JM03_ERECY G8JM03_ERECY G8JME6_ERECY G8JME6_ERECY G8JMQ0_ERECY G8JMQ0_ERECY PIF1 PIF1 MCM7 MCM7 G8JN02_ERECY G8JN02_ERECY G8JN35_ERECY G8JN35_ERECY G8JNL8_ERECY G8JNL8_ERECY G8JNP3_ERECY G8JNP3_ERECY G8JP52_ERECY G8JP52_ERECY G8JRW0_ERECY G8JRW0_ERECY G8JPG7_ERECY G8JPG7_ERECY G8JPN8_ERECY G8JPN8_ERECY G8JPV3_ERECY G8JPV3_ERECY G8JQ31_ERECY G8JQ31_ERECY I6NE69_ERECY I6NE69_ERECY I6NE19_ERECY I6NE19_ERECY I6NDM1_ERECY I6NDM1_ERECY
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
I6NDL0_ERECYZn(2)-C6 fungal-type domain-containing protein. (826 aa)
I6NDK9_ERECYUncharacterized protein. (717 aa)
I6NDB5_ERECYHistone H2B; Belongs to the histone H2B family. (127 aa)
I6NDB4_ERECYHistone H2A; Belongs to the histone H2A family. (131 aa)
I6NDB2_ERECYHMG box domain-containing protein. (224 aa)
I6ND34_ERECYUncharacterized protein. (168 aa)
I6ND16_ERECYTranscription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (299 aa)
I6NCQ1_ERECYDNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (873 aa)
I6NCP7_ERECYZn(2)-C6 fungal-type domain-containing protein. (903 aa)
I6NCM1_ERECYDNA damage checkpoint control protein RAD17; Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes; Belongs to the rad1 family. (387 aa)
G8JXV0_ERECYZn(2)-C6 fungal-type domain-containing protein. (885 aa)
G8JXQ9_ERECYDNA helicase; Belongs to the MCM family. (882 aa)
G8JXL9_ERECYH15 domain-containing protein. (191 aa)
G8JX98_ERECYNDT80 domain-containing protein. (633 aa)
G8JX42_ERECYUncharacterized protein. (133 aa)
G8JWS6_ERECYResponse regulatory domain-containing protein. (496 aa)
G8JWR3_ERECYHMG box domain-containing protein. (94 aa)
G8JWR2_ERECYProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (259 aa)
G8JWP5_ERECYZn(2)-C6 fungal-type domain-containing protein. (898 aa)
RRM3ATP-dependent DNA helicase RRM3; 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein- DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G- quadruplex (G4) unwindi [...] (730 aa)
G8JW81_ERECYUncharacterized protein. (464 aa)
G8JW66_ERECYZn(2)-C6 fungal-type domain-containing protein. (943 aa)
G8JVV0_ERECYTranscription initiation factor IIF subunit alpha; TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. Belongs to the TFIIF alpha subunit family. (629 aa)
G8JVP8_ERECYMADS-box domain-containing protein. (598 aa)
PIM1Lon protease homolog, mitochondrial; ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner; Belongs to the peptidase S16 family. (1096 aa)
G8JV74_ERECYReplication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (620 aa)
G8JUW4_ERECYDNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (1038 aa)
G8JU98_ERECYUncharacterized protein. (366 aa)
G8JTS1_ERECYBZIP domain-containing protein. (337 aa)
G8JTJ6_ERECYZn(2)-C6 fungal-type domain-containing protein. (627 aa)
G8JTB6_ERECYHMG box domain-containing protein. (250 aa)
G8JT78_ERECYDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (638 aa)
G8JT57_ERECYHistone H2B; Belongs to the histone H2B family. (132 aa)
G8JT56_ERECYHistone H2A; Belongs to the histone H2A family. (131 aa)
G8JT29_ERECYHomeobox domain-containing protein. (431 aa)
G8JST9_ERECYUncharacterized protein. (784 aa)
G8JSK1_ERECYUncharacterized protein. (606 aa)
G8JSI9_ERECYDNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (395 aa)
G8JSI5_ERECYZn(2)-C6 fungal-type domain-containing protein. (1100 aa)
G8JSF0_ERECYDNA damage-binding protein CMR1; DNA-binding protein that binds to both single- and double- stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes. (521 aa)
G8JSC3_ERECYZn(2)-C6 fungal-type domain-containing protein. (1577 aa)
G8JS92_ERECYDNA primase large subunit; DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication; Belongs to the eukaryotic-type primase large subunit family. (509 aa)
G8JS37_ERECYHMG box domain-containing protein. (482 aa)
G8JRW3_ERECYZn(2)-C6 fungal-type domain-containing protein. (1041 aa)
G8JQ32_ERECYMADS-box domain-containing protein. (220 aa)
G8JQ47_ERECYHistone domain-containing protein. (203 aa)
G8JQ52_ERECYHSF_DOMAIN domain-containing protein. (756 aa)
G8JQJ5_ERECYUncharacterized protein. (1047 aa)
G8JQL3_ERECYDNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1233 aa)
G8JQR1_ERECYMCM domain-containing protein; Belongs to the MCM family. (965 aa)
G8JQY1_ERECYDNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (660 aa)
G8JQZ0_ERECYHistone H2A; Belongs to the histone H2A family. (133 aa)
G8JR51_ERECYZn(2)-C6 fungal-type domain-containing protein. (1144 aa)
G8JR54_ERECYDNA helicase; Belongs to the MCM family. (774 aa)
G8JRQ9_ERECYHistone H3; Belongs to the histone H3 family. (136 aa)
G8JRR0_ERECYHistone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
G8JRU6_ERECYHomeobox domain-containing protein. (491 aa)
G8JM02_ERECYHomeobox domain-containing protein. (230 aa)
G8JM03_ERECYAlpha box domain-containing protein. (263 aa)
G8JME6_ERECYDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2184 aa)
G8JMQ0_ERECYOrigin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (1031 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (884 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (813 aa)
G8JN02_ERECYDNA helicase; Belongs to the MCM family. (1025 aa)
G8JN35_ERECYHMG box domain-containing protein. (449 aa)
G8JNL8_ERECYDNA helicase; Belongs to the MCM family. (890 aa)
G8JNP3_ERECYDNA polymerase. (1469 aa)
G8JP52_ERECYHSF_DOMAIN domain-containing protein. (529 aa)
G8JRW0_ERECYZn(2)-C6 fungal-type domain-containing protein. (847 aa)
G8JPG7_ERECYZn(2)-C6 fungal-type domain-containing protein. (1198 aa)
G8JPN8_ERECYHomeobox domain-containing protein. (349 aa)
G8JPV3_ERECYFork-head domain-containing protein. (605 aa)
G8JQ31_ERECYDNA_MISMATCH_REPAIR_2 domain-containing protein; Component of the post-replicative DNA mismatch repair system (MMR). (954 aa)
I6NE69_ERECYDNA polymerase. (1092 aa)
I6NE19_ERECYHSF_DOMAIN domain-containing protein. (572 aa)
I6NDM1_ERECYDNA polymerase. (1475 aa)
Your Current Organism:
Eremothecium cymbalariae
NCBI taxonomy Id: 931890
Other names: E. cymbalariae DBVPG#7215, Eremothecium cymbalariae DBVPG#7215
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