STRINGSTRING
cysG_1 cysG_1 yvqK yvqK hemA hemA hemB hemB hemL hemL cysG_2 cysG_2 cbiX cbiX cobO cobO cobT_2 cobT_2 cobS-2 cobS-2 ANC45723.1 ANC45723.1 cobD cobD cobD-2 cobD-2 cobP cobP cobQ cobQ hemC hemC ANC45747.1 ANC45747.1 hemX hemX ANC45749.1 ANC45749.1 cobD-3 cobD-3 ANC46566.1 ANC46566.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cysG_1uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
yvqKCobalamin adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Cob(I)alamin adenosyltransferase family. (190 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (426 aa)
hemBDelta-aminolevulinic acid dehydratase; Catalyzes the formation of porphobilinogen from 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (332 aa)
hemLGlutamate-1-semialdehyde aminotransferase; Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
cysG_2uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (262 aa)
cbiXCobalamin biosynthesis protein CbiX; Derived by automated computational analysis using gene prediction method: Protein Homology. (126 aa)
cobOcob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (212 aa)
cobT_2Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (360 aa)
cobS-2adenosylcobinamide-GDP ribazoletransferase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (257 aa)
ANC45723.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (199 aa)
cobDHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
cobD-2Cobalamin biosynthesis protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (326 aa)
cobPBifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (183 aa)
cobQCobyric acid synthase CobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (508 aa)
hemCHydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (322 aa)
ANC45747.1Hypothetical protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (305 aa)
hemXHypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (387 aa)
ANC45749.1Heme biosynthesis protein HemY; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
cobD-3Coenzyme A pyrophosphatase; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (312 aa)
ANC46566.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
Your Current Organism:
Pandoraea pnomenusa
NCBI taxonomy Id: 93220
Other names: ATCC BAA-63, ATCC:BAA:63, CCM 4978, CCUG 38742, CIP 106626, DSM 16536, LMG 18087, LMG:18087, NCTC 13160, P. pnomenusa, Pandoraea pnomenusa Coenye et al. 2000, Pandoraea sp. RB-44
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.