STRINGSTRING
ANC46878.1 ANC46878.1 cysJ_2 cysJ_2 cysI cysI gshA gshA hcl_1 hcl_1 sir sir acsA_1 acsA_1 kbl_1 kbl_1 ANC43208.1 ANC43208.1 bioK bioK tpa tpa dxs_1 dxs_1 ANC46957.1 ANC46957.1 bclA_1 bclA_1 prpE prpE ANC43453.1 ANC43453.1 metE_2 metE_2 bclA_2 bclA_2 ANC43576.1 ANC43576.1 thiC thiC ywrD_2 ywrD_2 thiD_2 thiD_2 kbl_2 kbl_2 ANC44208.1 ANC44208.1 thiL thiL accC accC thiE_1 thiE_1 thiG thiG thiS thiS ANC44553.1 ANC44553.1 bioA_1 bioA_1 metK metK metX metX metF metF ANC44951.1 ANC44951.1 bioB bioB bioD1 bioD1 bioF bioF bioA_2 bioA_2 metH_1 metH_1 ANC45060.1 ANC45060.1 lipA lipA gshB gshB bioC_2 bioC_2 ANC45254.1 ANC45254.1 mdeA_3 mdeA_3 mtnN mtnN thiE_2 thiE_2 acsA_3 acsA_3 ywrD_3 ywrD_3 ggt ggt ywrD_4 ywrD_4 cysH cysH cysM cysM dxs_2 dxs_2 acsA_4 acsA_4 asd asd accD accD metZ metZ cysE_2 cysE_2 accA accA folD folD ANC46355.1 ANC46355.1 hom hom thiD_1 thiD_1 metE_1 metE_1 ANC46597.1 ANC46597.1 ANC46627.1 ANC46627.1 cysE_1 cysE_1 ywrD_1 ywrD_1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANC46878.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (117 aa)
cysJ_2Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (621 aa)
cysISulfite reductase; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (572 aa)
gshAGlutamate--cysteine ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily. (520 aa)
hcl_1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (562 aa)
sirNitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (668 aa)
acsA_1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (540 aa)
kbl_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
ANC43208.1Extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (125 aa)
bioKHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (459 aa)
tpaHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (461 aa)
dxs_11-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (637 aa)
ANC46957.1Gentisate 1,2-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
bclA_12-aminobenzoate-CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (547 aa)
prpEEmrB/QacA subfamily drug resistance transporter; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (633 aa)
ANC43453.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (345 aa)
metE_25-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (778 aa)
bclA_24-hydroxybenzoate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
ANC43576.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
thiCPhosphomethylpyrimidine synthase ThiC; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (638 aa)
ywrD_2Gamma-glutamyltranspeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (580 aa)
thiD_2Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (279 aa)
kbl_2Glycine C-acetyltransferase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (405 aa)
ANC44208.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (322 aa)
accCacetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (454 aa)
thiE_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (234 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (281 aa)
thiSThiamine biosynthesis protein ThiS; With ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (65 aa)
ANC44553.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
bioA_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (447 aa)
metKMethionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (392 aa)
metXHomoserine O-acetyltransferase; Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine. (401 aa)
metFMethylenetetrahydrofolate reductase [NAD(P)H]; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (276 aa)
ANC44951.1Omega amino acid--pyruvate aminotransferase; Catalyzes the formation of pyruvate and beta-alanine from L-alanine and 3-oxopropanoate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (442 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa)
bioD1Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (264 aa)
bioF8-amino-7-oxononanoate synthase; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. (405 aa)
bioA_2Adenosylmethionine--8-amino-7-oxononanoate aminotransferase BioA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (471 aa)
metH_1Hypothetical protein; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (794 aa)
ANC45060.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (174 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (335 aa)
gshBGlutathione synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic GSH synthase family. (312 aa)
bioC_2Amidophosphoribosyltransferase; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. (306 aa)
ANC45254.1Gentisate 1,2-dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
mdeA_3Methionine gamma-lyase; Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
mtnN5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (253 aa)
thiE_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
acsA_3Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa)
ywrD_3Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
ggtGamma-glutamyltransferase; Periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; Derived by automated computational analysis using gene prediction method: Protein Homology. (575 aa)
ywrD_4Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (545 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. (238 aa)
cysMCysteine synthase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (300 aa)
dxs_21-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (648 aa)
acsA_4AMP-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (552 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (365 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (291 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (395 aa)
cysE_2Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (322 aa)
folDBifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (284 aa)
ANC46355.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (304 aa)
homHomoserine dehydrogenase; Catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
thiD_1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
metE_15-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (762 aa)
ANC46597.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
ANC46627.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
cysE_1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (313 aa)
ywrD_1Gamma-glutamyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (556 aa)
Your Current Organism:
Pandoraea pnomenusa
NCBI taxonomy Id: 93220
Other names: ATCC BAA-63, ATCC:BAA:63, CCM 4978, CCUG 38742, CIP 106626, DSM 16536, LMG 18087, LMG:18087, NCTC 13160, P. pnomenusa, Pandoraea pnomenusa Coenye et al. 2000, Pandoraea sp. RB-44
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