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acnA acnA ybdL ybdL ydcR_3 ydcR_3 lysN_2 lysN_2 prpC2 prpC2 ilvD_5 ilvD_5 ilvD_4 ilvD_4 ilvB_2 ilvB_2 ANC45542.1 ANC45542.1 argC_2 argC_2 argC_1 argC_1 gabR_3 gabR_3 leuA_2 leuA_2 ilvE ilvE lysN_1 lysN_1 mngR mngR ANC45097.1 ANC45097.1 ydcR_2 ydcR_2 argB argB yjiR_3 yjiR_3 ydcR_1 ydcR_1 argJ argJ ANC43998.1 ANC43998.1 yjiR_2 yjiR_2 ANC43886.1 ANC43886.1 icd_2 icd_2 ypeA ypeA argD argD gabR_2 gabR_2 yjiR_1 yjiR_1 leuC_1 leuC_1 gabR_1 gabR_1 icd_1 icd_1 yidP yidP dmdA dmdA hacB hacB ilvD_1 ilvD_1 acnB acnB argE_2 argE_2 gltA gltA leuC_2 leuC_2 leuD1 leuD1 leuB leuB asd asd ANC47424.1 ANC47424.1 lysC lysC argA argA ANC47450.1 ANC47450.1 citZ citZ dat_1 dat_1 ilvI ilvI ilvH ilvH ilvC ilvC leuA_1 leuA_1 argE_1 argE_1 yvoA_1 yvoA_1 ANC47502.1 ANC47502.1 dgdA dgdA yvoA_2 yvoA_2 ilvB_1 ilvB_1 frlR frlR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (902 aa)
ybdLMethionine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
ydcR_3GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
lysN_22-aminoadipate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
prpC2Citrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
ilvD_5Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (622 aa)
ilvD_4Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (557 aa)
ilvB_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (550 aa)
ANC45542.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (78 aa)
argC_2N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (347 aa)
argC_1N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 2 subfamily. (309 aa)
gabR_32-aminoadipate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)
leuA_22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (570 aa)
ilvECatalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
lysN_12-aminoadipate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
mngRPhosphonate metabolism transcriptional regulator PhnF; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
ANC45097.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (452 aa)
ydcR_2GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (482 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
yjiR_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (454 aa)
ydcR_1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (409 aa)
ANC43998.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (326 aa)
yjiR_22-aminoadipate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
ANC43886.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (104 aa)
icd_2Isocitrate dehydrogenase (NADP(+)); Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
ypeAGNAT family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (159 aa)
argDAcetylornithine aminotransferase; DapATase; functions in arginine biosynthetic pathway; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (389 aa)
gabR_2DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
yjiR_1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
leuC_13-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (668 aa)
gabR_1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
icd_1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (746 aa)
yidPGntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (266 aa)
dmdA3-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
hacB3-isopropylmalate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LeuD family. (190 aa)
ilvD_1Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (581 aa)
acnBAconitate hydratase B; Catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aconitase/IPM isomerase family. (861 aa)
argE_2Acetylornithine deacetylase; Catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine; Derived by automated computational analysis using gene prediction method: Protein Homology. (419 aa)
gltACitrate (Si)-synthase; Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cit [...] (433 aa)
leuC_2Isopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
leuD13-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (216 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (355 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (365 aa)
ANC47424.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
lysCAspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (416 aa)
argAOxidative damage protection protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the acetyltransferase family. ArgA subfamily. (449 aa)
ANC47450.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (408 aa)
citZExcisionase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
dat_1Branched-chain amino acid transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
ilvIAcetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology. (589 aa)
ilvHAcetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
leuA_12-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (514 aa)
argE_1Acetylornithine deacetylase; Catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
yvoA_1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (254 aa)
ANC47502.1Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
dgdA2,2-dialkylglycine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (438 aa)
yvoA_2Histidine utilization repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
ilvB_1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (606 aa)
frlRGntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
Your Current Organism:
Pandoraea pnomenusa
NCBI taxonomy Id: 93220
Other names: ATCC BAA-63, ATCC:BAA:63, CCM 4978, CCUG 38742, CIP 106626, DSM 16536, LMG 18087, LMG:18087, NCTC 13160, P. pnomenusa, Pandoraea pnomenusa Coenye et al. 2000, Pandoraea sp. RB-44
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