STRINGSTRING
AJC15612.1 AJC15612.1 ydiA ydiA ppsA ppsA vraS vraS hipA hipA qseC_3 qseC_3 dosC_3 dosC_3 prs_2 prs_2 nreB_3 nreB_3 rstB_2 rstB_2 envZ_2 envZ_2 tmk tmk nnr nnr pgi pgi envZ_1 envZ_1 ydjH ydjH lpd lpd sucA sucA relA relA dgkA dgkA APD12682.1 APD12682.1 gmk gmk rpfC_1 rpfC_1 glpK glpK glxK glxK thrB thrB phnN_2 phnN_2 ppk ppk phoR_2 phoR_2 selD selD APD12324.1 APD12324.1 qseC_2 qseC_2 fda fda pykA pykA pgk pgk phoR_1 phoR_1 gntK gntK ybbH_1 ybbH_1 gpmA_2 gpmA_2 anmK anmK ubiB ubiB rpiR rpiR cusS_1 cusS_1 rstB_1 rstB_1 AJC15906.1 AJC15906.1 phnN_1 phnN_1 hprK hprK ispE ispE prs_1 prs_1 gpmA gpmA ptsI ptsI manX manX dctB dctB coaX coaX aceK aceK qseC_1 qseC_1 argB argB regB regB pyrH pyrH glnL_1 glnL_1 nreB_1 nreB_1 frzE frzE AJC15460.1 AJC15460.1 cheA_2 cheA_2 degS_2 degS_2 rssA_3 rssA_3 baeS baeS AJC15268.1 AJC15268.1 aroK_3 aroK_3 qseC_6 qseC_6 coaE coaE proB proB adoK adoK thiL thiL AJC18457.1 AJC18457.1 qseC_5 qseC_5 thiD_2 thiD_2 aceE_3 aceE_3 aceE_2 aceE_2 AJC18350.1 AJC18350.1 ppnK ppnK qseC_4 qseC_4 dgk dgk folK folK AJC18287.1 AJC18287.1 adk adk AJC18283.1 AJC18283.1 lpxK lpxK ribF ribF envZ_5 envZ_5 AJC18233.1 AJC18233.1 envZ_4 envZ_4 rdoA rdoA cheA_1 cheA_1 rstB_3 rstB_3 AJC18066.1 AJC18066.1 degS_1 degS_1 glk glk cmk cmk hldE_2 hldE_2 cobC cobC cobP cobP envZ_3 envZ_3 AJC17859.1 AJC17859.1 phoR_3 phoR_3 eno eno pleD_3 pleD_3 tpiA tpiA AJC19070.2 AJC19070.2 lysC lysC ndk ndk aceE_1 aceE_1 aceF aceF pdxY pdxY glnL_2 glnL_2 ypdA ypdA thiD_1 thiD_1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AJC15612.1Polyphosphate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
ydiAPhosphoenolpyruvate synthase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (265 aa)
ppsAPhosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (796 aa)
vraSHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (588 aa)
hipARegulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
qseC_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (473 aa)
dosC_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (564 aa)
prs_2Phosphoribosylpyrophosphate synthetase; Catalyzes the formation of PRPP from ATP and ribose 5-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribose-phosphate pyrophosphokinase family. (302 aa)
nreB_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
rstB_2Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
envZ_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (220 aa)
nnrHypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (509 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (552 aa)
envZ_1Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
ydjH2-dehydro-3-deoxygluconokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (309 aa)
lpdDihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
sucA2-oxoglutarate dehydrogenase E1 component; Derived by automated computational analysis using gene prediction method: Protein Homology. (952 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (756 aa)
dgkADiacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (144 aa)
APD12682.1Sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (949 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (225 aa)
rpfC_1Hybrid sensor histidine kinase/response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (1139 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (500 aa)
glxKGlycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (383 aa)
thrBHomoserine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudomonas-type ThrB family. (323 aa)
phnN_2Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (592 aa)
ppkRNA degradosome polyphosphate kinase; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (704 aa)
phoR_2Phosphate regulon sensor histidine kinase PhoR; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
selDSelenide, water dikinase SelD; Synthesizes selenophosphate from selenide and ATP. (365 aa)
APD12324.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (424 aa)
qseC_2Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
fdaFructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
pykAPyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (477 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (401 aa)
phoR_1Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (496 aa)
gntKGluconate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
ybbH_1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
gpmA_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (235 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (362 aa)
ubiBUbiquinone biosynthesis regulatory protein kinase UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (519 aa)
rpiRTranscriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
cusS_1Two-component sensor histidine kinase; Member of a two-component regulatory system. (469 aa)
rstB_1Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
AJC15906.1DUF4743 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (283 aa)
phnN_1Phosphonate metabolism protein/1,5-bisphosphokinase (PRPP-forming) PhnN; Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP). (190 aa)
hprKHPr kinase/phosphorylase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). (321 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (289 aa)
prs_1Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
ptsIPhosphoenolpyruvate--protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (578 aa)
manXPTS sugar transporter subunit IIB; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
dctBTwo-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (666 aa)
coaXHypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (355 aa)
aceKBifunctional isocitrate dehydrogenase kinase/phosphatase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation. (606 aa)
qseC_1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
regBTwo-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (237 aa)
glnL_1PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (783 aa)
nreB_1Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
frzEHybrid sensor histidine kinase/response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (832 aa)
AJC15460.1Signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
cheA_2Chemotaxis protein CheA; Derived by automated computational analysis using gene prediction method: Protein Homology. (746 aa)
degS_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (306 aa)
rssA_3Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
baeSHypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (370 aa)
AJC15268.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (1043 aa)
aroK_3Shikimate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
qseC_6Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (497 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (377 aa)
adoKSugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (333 aa)
AJC18457.1Aminoglycoside phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
qseC_5Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (506 aa)
thiD_2Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (278 aa)
aceE_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
aceE_2Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (891 aa)
AJC18350.1Adenylyl-sulfate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
ppnKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (339 aa)
qseC_4Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
dgkDeoxyadenosine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (218 aa)
folK2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
AJC18287.1Transglutaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (221 aa)
AJC18283.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0434 family. (68 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (335 aa)
ribFRiboflavin biosynthesis protein RibF; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (330 aa)
envZ_5Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
AJC18233.1Polyphosphate kinase 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
envZ_4Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
rdoAStress response serine/threonine protein kinase YihE; A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response. (336 aa)
cheA_1Chemotaxis protein CheA; Derived by automated computational analysis using gene prediction method: Protein Homology. (818 aa)
rstB_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (432 aa)
AJC18066.1Sugar kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (305 aa)
degS_1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (501 aa)
glkGlucokinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. (623 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
hldE_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (329 aa)
cobCHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
cobPBifunctional adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (188 aa)
envZ_3Two-component sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
AJC17859.1Hrp-dependent type III effector protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (426 aa)
phoR_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (510 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (427 aa)
pleD_3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (657 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
AJC19070.2Fructose-2,6-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
lysCAspartate kinase; Catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (416 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
aceE_1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (895 aa)
aceFDihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (551 aa)
pdxYPyridoxal kinase; Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. (285 aa)
glnL_2PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
ypdAHypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (393 aa)
thiD_1Bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
Your Current Organism:
Pandoraea sputorum
NCBI taxonomy Id: 93222
Other names: ATCC BAA-64, ATCC:BAA:64, CCUG 45026, CIP 106624, DSM 21091, LMG 18819, LMG:18819, NCTC 13161, P. sputorum, Pandoraea sputorum Coenye et al. 2000
Server load: medium (52%) [HD]