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mii_1 mii_1 yddE_1 yddE_1 nahD_1 nahD_1 ygbM ygbM gyrB gyrB APD12705.1 APD12705.1 hldD hldD gyrA gyrA AJC18013.1 AJC18013.1 hemL hemL dmpI dmpI pcaB pcaB rluC rluC rluE rluE fkpB fkpB AJC18221.1 AJC18221.1 rmlC rmlC rpiA rpiA rsuA rsuA fbp_2 fbp_2 ppiB ppiB AJC17503.1 AJC17503.1 trpF trpF truA truA tpiA tpiA slyD slyD parC parC parE parE AJC19102.1 AJC19102.1 ygeA ygeA ycjG ycjG topB topB dapF dapF gmhA gmhA nahD_3 nahD_3 gpmA gpmA kdsD kdsD AJC16046.1 AJC16046.1 gpmA_2 gpmA_2 queA queA yrpC yrpC purE purE ulaF ulaF AJC16452.1 AJC16452.1 glmM glmM maiA maiA ywhB ywhB mii_2 mii_2 maiA-2 maiA-2 ilvC ilvC rluD rluD tig tig ppiD ppiD pgi pgi nnr nnr cbf2 cbf2 AJC17065.1 AJC17065.1 yddE_2 yddE_2 galE galE dxr dxr rluF rluF dadX dadX hyi hyi truB truB rluB rluB algC algC surA surA rpe rpe prsA3 prsA3 hisA hisA hpcE hpcE APD12640.1 APD12640.1 capD capD fcl fcl gmhA1 gmhA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mii_14-oxalomesaconate tautomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
yddE_1Phenazine biosynthesis protein PhzC/PhzF; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
nahD_12-hydroxychromene-2-carboxylate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (201 aa)
ygbMHydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the hyi family. (264 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (825 aa)
APD12705.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
hldDADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (334 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (873 aa)
AJC18013.1Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
dmpI4-oxalocrotonate tautomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 4-oxalocrotonate tautomerase family. (69 aa)
pcaB3-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
rluCRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (334 aa)
rluEPseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (196 aa)
fkpBPeptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (151 aa)
AJC18221.14-oxalocrotonate tautomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 4-oxalocrotonate tautomerase family. (133 aa)
rmlCdTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (230 aa)
rsuAHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (223 aa)
fbp_2Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (113 aa)
ppiBPeptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (195 aa)
AJC17503.1Cyclophilin; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (164 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (224 aa)
truAtRNA pseudouridine(38-40) synthase TruA; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (266 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (255 aa)
slyDPeptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
parCDNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (778 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (659 aa)
AJC19102.1Disulfide bond formation protein DsbA; Derived by automated computational analysis using gene prediction method: Protein Homology. (217 aa)
ygeAAspartate/glutamate racemase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/glutamate racemases family. (233 aa)
ycjGDipeptide epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
topBDNA topoisomerase III; Decatenates replicating daughter chromosomes; Derived by automated computational analysis using gene prediction method: Protein Homology. (902 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (283 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (195 aa)
nahD_32-hydroxychromene-2-carboxylate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
gpmAPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (248 aa)
kdsDArabinose-5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SIS family. GutQ/KpsF subfamily. (326 aa)
AJC16046.1DUF4440 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
gpmA_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate mutase family. (235 aa)
queAtRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (360 aa)
yrpCGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (312 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (168 aa)
ulaFHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
AJC16452.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/glutamate racemases family. (242 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (447 aa)
maiAAsp/Glu racemase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. (250 aa)
ywhB4-oxalocrotonate tautomerase; 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 4-oxalocrotonate tautomerase family. (64 aa)
mii_2Putative methylaconitate Delta-isomerase PrpF; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
maiA-2Asp/Glu racemase; Catalyzes cis-trans isomerization of the C2-C3 double bond in maleate to yield fumarate. (249 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
rluDRNA pseudouridine synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (386 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (446 aa)
ppiDHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (641 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (552 aa)
nnrHypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epi [...] (509 aa)
cbf2Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
AJC17065.14-oxalocrotonate tautomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 4-oxalocrotonate tautomerase family. (71 aa)
yddE_2Phenazine biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
galEUDP-glucose 4-epimerase GalE; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (340 aa)
dxr1-deoxy-D-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (399 aa)
rluFHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (660 aa)
dadXAlanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (356 aa)
hyiHydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the hyi family. (263 aa)
truBtRNA pseudouridine(55) synthase TruB; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (328 aa)
rluB23S rRNA pseudouridylate synthase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (597 aa)
algCLipopolysaccharide heptosyltransferase I; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
surAMolecular chaperone SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (452 aa)
rpeRibulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (226 aa)
prsA3Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
hpcE5-carboxymethyl-2-hydroxymuconate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
APD12640.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (261 aa)
capDCapsular biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (640 aa)
fclGDP-fucose synthetase; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (328 aa)
gmhA1Phosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (190 aa)
Your Current Organism:
Pandoraea sputorum
NCBI taxonomy Id: 93222
Other names: ATCC BAA-64, ATCC:BAA:64, CCUG 45026, CIP 106624, DSM 21091, LMG 18819, LMG:18819, NCTC 13161, P. sputorum, Pandoraea sputorum Coenye et al. 2000
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