STRINGSTRING
PDE_05289 PDE_05289 PDE_04391 PDE_04391 PDE_08750 PDE_08750 PDE_04522 PDE_04522 PDE_04897 PDE_04897 PDE_09892 PDE_09892 PDE_00993 PDE_00993 URM1 URM1 PDE_00578 PDE_00578 PDE_00670 PDE_00670 PDE_00705 PDE_00705 PDE_00850 PDE_00850 PDE_01010 PDE_01010 PDE_01568 PDE_01568 PDE_01628 PDE_01628 PDE_01744 PDE_01744 PDE_01401 PDE_01401 PDE_09903 PDE_09903 PDE_05674 PDE_05674 PDE_05784 PDE_05784 PDE_05991 PDE_05991 PDE_00128 PDE_00128 PDE_02198 PDE_02198 PDE_06147 PDE_06147 PDE_07737 PDE_07737 PDE_02213 PDE_02213 PDE_02045 PDE_02045 PDE_00620 PDE_00620 PDE_00732 PDE_00732 PDE_02297 PDE_02297 PDE_00922 PDE_00922 PDE_02507 PDE_02507 PDE_02859 PDE_02859 PDE_02986 PDE_02986 PDE_03076 PDE_03076 PDE_02848 PDE_02848 PDE_02919 PDE_02919 PDE_01513 PDE_01513 PDE_01554 PDE_01554 PDE_03581 PDE_03581 PDE_01609 PDE_01609 PDE_03671 PDE_03671 PDE_01770 PDE_01770 PDE_02084 PDE_02084 PDE_03810 PDE_03810 PDE_02244 PDE_02244 PDE_02249 PDE_02249 PDE_02289 PDE_02289 PDE_04133 PDE_04133 PDE_04429 PDE_04429 PDE_02906 PDE_02906 PDE_05155 PDE_05155 PDE_03202 PDE_03202 PDE_03212 PDE_03212 PDE_03662 PDE_03662 PDE_03722 PDE_03722 PDE_05400 PDE_05400 PDE_03962 PDE_03962 PDE_05964 PDE_05964 PDE_07883 PDE_07883 PDE_07898 PDE_07898 PDE_08059 PDE_08059 PDE_08069 PDE_08069 PDE_08234 PDE_08234 PDE_09706 PDE_09706 PDE_04928 PDE_04928 PDE_08675 PDE_08675 PDE_00458 PDE_00458 PDE_05570 PDE_05570 PDE_01148 PDE_01148 PDE_01484 PDE_01484 PDE_01827 PDE_01827 PDE_06705 PDE_06705 PDE_02520 PDE_02520 PDE_02796 PDE_02796 PDE_07318 PDE_07318 NCS2 NCS2 PDE_07468 PDE_07468 PDE_07804 PDE_07804 PDE_03498 PDE_03498 PDE_03538 PDE_03538 PDE_03863 PDE_03863 PDE_00489 PDE_00489 PDE_08535 PDE_08535 PDE_04336 PDE_04336 PDE_06270 PDE_06270 PDE_06535 PDE_06535 PDE_06224 PDE_06224 PDE_04611 PDE_04611 PDE_06234 PDE_06234 PDE_06818 PDE_06818 PDE_06989 PDE_06989 PDE_07024 PDE_07024 PDE_05061 PDE_05061 PDE_06963 PDE_06963 PDE_07410 PDE_07410 PDE_07319 PDE_07319 PDE_07324 PDE_07324 PDE_07339 PDE_07339 PDE_07780 PDE_07780 PDE_07801 PDE_07801 PDE_07826 PDE_07826 PDE_07906 PDE_07906 PDE_07694 PDE_07694 PDE_05990 PDE_05990 PDE_06101 PDE_06101 PDE_06321 PDE_06321 PDE_08151 PDE_08151 PDE_08171 PDE_08171 PDE_08467 PDE_08467 PDE_08532 PDE_08532 PDE_08386 PDE_08386 PDE_08792 PDE_08792 PDE_07025 PDE_07025 PDE_08881 PDE_08881 PDE_09479 PDE_09479 PDE_09213 PDE_09213 PDE_09559 PDE_09559 PDE_09393 PDE_09393 PDE_07862 PDE_07862 PDE_07917 PDE_07917 PDE_08023 PDE_08023 PDE_08068 PDE_08068 PDE_08368 PDE_08368 PDE_08808 PDE_08808 PDE_08893 PDE_08893 PDE_08903 PDE_08903 PDE_08958 PDE_08958 PDE_09023 PDE_09023 PDE_09033 PDE_09033 PDE_09360 PDE_09360 PDE_00869 PDE_00869 PDE_01134 PDE_01134 PDE_01878 PDE_01878 NCS6 NCS6 PDE_02908 PDE_02908 PDE_03384 PDE_03384 PDE_03849 PDE_03849 PDE_03869 PDE_03869 PDE_04000 PDE_04000 PDE_04207 PDE_04207 uba4 uba4 PDE_00245 PDE_00245 PDE_00541 PDE_00541
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDE_05289SP-RING-type domain-containing protein. (997 aa)
PDE_04391Uncharacterized protein. (667 aa)
PDE_08750UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (234 aa)
PDE_04522RING-type domain-containing protein. (775 aa)
PDE_04897Ubiquitin-like domain-containing protein. (154 aa)
PDE_09892TPR_REGION domain-containing protein. (772 aa)
PDE_00993RING-type domain-containing protein. (432 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (113 aa)
PDE_00578BTB domain-containing protein. (689 aa)
PDE_00670Ubiquitin-like domain-containing protein. (94 aa)
PDE_00705WLM domain-containing protein. (345 aa)
PDE_00850RING-type domain-containing protein. (383 aa)
PDE_01010Uncharacterized protein. (519 aa)
PDE_01568UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
PDE_01628Uncharacterized protein. (462 aa)
PDE_01744RING-type domain-containing protein. (371 aa)
PDE_01401zf-RING-like domain-containing protein. (321 aa)
PDE_09903TPR_REGION domain-containing protein. (704 aa)
PDE_05674Uncharacterized protein. (780 aa)
PDE_05784UBIQUITIN_CONJUGAT_2 domain-containing protein. (276 aa)
PDE_05991RING-type domain-containing protein. (87 aa)
PDE_00128CULLIN_2 domain-containing protein; Belongs to the cullin family. (764 aa)
PDE_02198RING-type domain-containing protein. (185 aa)
PDE_06147UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
PDE_07737WD_REPEATS_REGION domain-containing protein. (721 aa)
PDE_02213RING-CH-type domain-containing protein. (279 aa)
PDE_02045UBR-type domain-containing protein. (548 aa)
PDE_00620UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (463 aa)
PDE_00732RING-type domain-containing protein. (804 aa)
PDE_02297Uncharacterized protein. (405 aa)
PDE_00922Uncharacterized protein. (325 aa)
PDE_02507Autophagy_act_C domain-containing protein. (235 aa)
PDE_02859HECT domain-containing protein. (1240 aa)
PDE_02986Uncharacterized protein. (1636 aa)
PDE_03076Uncharacterized protein. (284 aa)
PDE_02848Ubiquitin-like domain-containing protein. (667 aa)
PDE_02919Uncharacterized protein. (414 aa)
PDE_01513Uncharacterized protein. (534 aa)
PDE_01554Uncharacterized protein. (2100 aa)
PDE_03581E3 ubiquitin protein ligase. (705 aa)
PDE_01609ANAPC5 domain-containing protein. (768 aa)
PDE_03671RING-type domain-containing protein. (529 aa)
PDE_01770Uncharacterized protein. (523 aa)
PDE_02084UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (184 aa)
PDE_03810Uncharacterized protein. (637 aa)
PDE_02244ThiF domain-containing protein. (423 aa)
PDE_02249Uncharacterized protein; Belongs to the SKP1 family. (160 aa)
PDE_02289RING-type domain-containing protein. (118 aa)
PDE_04133Ubiquitin-like domain-containing protein. (80 aa)
PDE_04429RING-type domain-containing protein. (377 aa)
PDE_02906HECT domain-containing protein. (1202 aa)
PDE_05155Uncharacterized protein. (702 aa)
PDE_03202Uncharacterized protein. (668 aa)
PDE_03212Uncharacterized protein. (409 aa)
PDE_03662U-box domain-containing protein. (1082 aa)
PDE_03722RING-type domain-containing protein. (532 aa)
PDE_05400RING-type domain-containing protein. (889 aa)
PDE_03962Uncharacterized protein. (770 aa)
PDE_05964Uncharacterized protein. (473 aa)
PDE_07883E3 ubiquitin-protein ligase PEP5. (953 aa)
PDE_07898TIP120 domain-containing protein. (1238 aa)
PDE_08059UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (151 aa)
PDE_08069Uncharacterized protein. (348 aa)
PDE_08234RBR-type E3 ubiquitin transferase. (509 aa)
PDE_09706UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (234 aa)
PDE_04928RING-type domain-containing protein. (150 aa)
PDE_08675RING-type domain-containing protein. (444 aa)
PDE_00458Uncharacterized protein. (534 aa)
PDE_05570Uncharacterized protein. (328 aa)
PDE_01148Uncharacterized protein. (131 aa)
PDE_01484F-box domain-containing protein. (580 aa)
PDE_01827CIA30 domain-containing protein. (231 aa)
PDE_06705HECT domain-containing protein. (4032 aa)
PDE_02520Uncharacterized protein. (1496 aa)
PDE_02796Pex2_Pex12 domain-containing protein. (484 aa)
PDE_07318Uncharacterized protein. (415 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (367 aa)
PDE_07468Uncharacterized protein. (585 aa)
PDE_07804RING-type domain-containing protein. (494 aa)
PDE_03498RING-type domain-containing protein. (301 aa)
PDE_03538RBR-type E3 ubiquitin transferase. (644 aa)
PDE_03863RING-type domain-containing protein. (844 aa)
PDE_00489Uncharacterized protein. (839 aa)
PDE_08535UBIQUITIN_CONJUGAT_2 domain-containing protein. (139 aa)
PDE_04336Helicase ATP-binding domain-containing protein. (2235 aa)
PDE_06270Uncharacterized protein. (955 aa)
PDE_06535Uncharacterized protein. (460 aa)
PDE_06224Uncharacterized protein. (642 aa)
PDE_04611UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (166 aa)
PDE_06234Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (606 aa)
PDE_06818Uncharacterized protein. (741 aa)
PDE_06989CULLIN_2 domain-containing protein; Belongs to the cullin family. (836 aa)
PDE_07024E3 ubiquitin-protein ligase. (822 aa)
PDE_05061UBIQUITIN_CONJUGAT_2 domain-containing protein. (154 aa)
PDE_06963CULLIN_2 domain-containing protein; Belongs to the cullin family. (950 aa)
PDE_07410CULLIN_2 domain-containing protein; Belongs to the cullin family. (874 aa)
PDE_07319Uncharacterized protein. (577 aa)
PDE_07324Uncharacterized protein. (474 aa)
PDE_07339Uncharacterized protein. (572 aa)
PDE_07780UBIQUITIN_CONJUGAT_2 domain-containing protein. (343 aa)
PDE_07801Uncharacterized protein. (409 aa)
PDE_07826Defective in cullin neddylation protein; Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. (269 aa)
PDE_07906Ubiquitin-activating enzyme E1-like; Belongs to the ubiquitin-activating E1 family. (634 aa)
PDE_07694UBA_e1_C domain-containing protein; Belongs to the ubiquitin-activating E1 family. (1033 aa)
PDE_05990Uncharacterized protein. (346 aa)
PDE_06101Uncharacterized protein. (381 aa)
PDE_06321RING-type domain-containing protein. (795 aa)
PDE_08151UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (180 aa)
PDE_08171Uncharacterized protein. (1029 aa)
PDE_08467Uncharacterized protein. (875 aa)
PDE_08532TPR_REGION domain-containing protein. (399 aa)
PDE_08386SH3 domain-containing protein. (913 aa)
PDE_08792HECT domain-containing protein. (1811 aa)
PDE_07025RING-type domain-containing protein. (410 aa)
PDE_08881SP-RING-type domain-containing protein. (507 aa)
PDE_09479Uncharacterized protein. (161 aa)
PDE_09213Uncharacterized protein. (274 aa)
PDE_09559UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (167 aa)
PDE_09393UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (219 aa)
PDE_07862Uncharacterized protein. (304 aa)
PDE_07917NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme. (561 aa)
PDE_08023RING-type domain-containing protein. (325 aa)
PDE_08068UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (168 aa)
PDE_08368E2_bind domain-containing protein. (423 aa)
PDE_08808RING-type domain-containing protein. (1531 aa)
PDE_08893RING-type domain-containing protein. (217 aa)
PDE_08903CHY-type domain-containing protein. (707 aa)
PDE_08958BTB domain-containing protein. (1666 aa)
PDE_09023BZIP domain-containing protein. (304 aa)
PDE_09033HECT domain-containing protein. (1338 aa)
PDE_09360WHIM1 domain-containing protein. (575 aa)
PDE_00869RING-type domain-containing protein. (130 aa)
PDE_01134BTB domain-containing protein. (217 aa)
PDE_01878RING-type domain-containing protein. (1044 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (417 aa)
PDE_02908RING-type domain-containing protein. (429 aa)
PDE_03384UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (149 aa)
PDE_03849Putative carbohydrate acetylesterase. (346 aa)
PDE_03869E3 ubiquitin-protein ligase; Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N- terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. (2151 aa)
PDE_04000Uncharacterized protein. (921 aa)
PDE_04207Uncharacterized protein. (807 aa)
uba4Adenylyltransferase and sulfurtransferase uba4; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (491 aa)
PDE_00245RING-type domain-containing protein. (1624 aa)
PDE_00541DOC domain-containing protein. (464 aa)
Your Current Organism:
Penicillium oxalicum
NCBI taxonomy Id: 933388
Other names: P. oxalicum 114-2, Penicillium oxalicum 114-2
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