(32 nodes) Terpenoid backbone biosynthesis network (Penicillium oxalicum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PDE_08061	Uncharacterized protein. (701 aa)
	PDE_02444	Peptidase_M48 domain-containing protein. (374 aa)
	PDE_04950	Prenylcys_lyase domain-containing protein. (546 aa)
	PDE_05015	Uncharacterized protein. (629 aa)
	PDE_04769	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (831 aa)
	PDE_05266	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1006 aa)
	PDE_03632	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family. (404 aa)
	PDE_03682	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (456 aa)
	PDE_05641	Uncharacterized protein. (331 aa)
	PDE_07205	Uncharacterized protein. (944 aa)
	PDE_09902	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (347 aa)
	PDE_08884	Uncharacterized protein. (459 aa)
	PDE_05644	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (448 aa)
	PDE_08475	Uncharacterized protein. (407 aa)
	PDE_03958	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding. (453 aa)
	PDE_08060	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (430 aa)
	PDE_05324	3-hydroxy-3-methylglutaryl coenzyme A reductase. (1130 aa)
	PDE_04823	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (458 aa)
	PDE_00149	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (372 aa)
	PDE_04172	Protein-S-isoprenylcysteine O-methyltransferase; Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family. (308 aa)
	PDE_03479	S5A_REDUCTASE domain-containing protein. (236 aa)
	PDE_01616	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (448 aa)
	PDE_00979	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
	PDE_10001	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (294 aa)
	PDE_07982	Nudix hydrolase domain-containing protein. (271 aa)
	PDE_09653	Uncharacterized protein. (416 aa)
	PDE_06875	Uncharacterized protein. (372 aa)
	PDE_07295	Phosphomevalonate kinase; Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (490 aa)
	PDE_00432	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (463 aa)
	PDE_01056	Uncharacterized protein. (348 aa)
	PDE_02067	DUF2236 domain-containing protein. (300 aa)
	PDE_01718	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (342 aa)

Your Current Organism:

Penicillium oxalicum

NCBI taxonomy Id: 933388
Other names: P. oxalicum 114-2, Penicillium oxalicum 114-2

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PDE_00149	PDE_00432	S8ATQ9	S7Z5V2	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.495
PDE_00149	PDE_01616	S8ATQ9	S8ALE0	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.878
PDE_00149	PDE_01718	S8ATQ9	S7Z991	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.741
PDE_00149	PDE_02067	S8ATQ9	S7Z933	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	DUF2236 domain-containing protein.	0.631
PDE_00149	PDE_03632	S8ATQ9	S7ZJ20	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.927
PDE_00149	PDE_03958	S8ATQ9	S8B3D7	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Protein farnesyltransferase subunit beta; Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.	0.887
PDE_00149	PDE_04823	S8ATQ9	S8AUQ2	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.495
PDE_00149	PDE_05324	S8ATQ9	S8AVW7	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.544
PDE_00149	PDE_05641	S8ATQ9	S7ZK60	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.881
PDE_00149	PDE_06875	S8ATQ9	S7ZT59	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.871
PDE_00149	PDE_07982	S8ATQ9	S7ZW79	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Nudix hydrolase domain-containing protein.	0.900
PDE_00149	PDE_08475	S8ATQ9	S8B3X9	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein.	0.879
PDE_00149	PDE_09902	S8ATQ9	S8BI78	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.913
PDE_00149	PDE_10001	S8ATQ9	S8A1K7	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.755
PDE_00432	PDE_00149	S7Z5V2	S8ATQ9	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.495
PDE_00432	PDE_00979	S7Z5V2	S8AJQ9	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family.	0.986
PDE_00432	PDE_01616	S7Z5V2	S8ALE0	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.513
PDE_00432	PDE_01718	S7Z5V2	S7Z991	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.619
PDE_00432	PDE_03632	S7Z5V2	S7ZJ20	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Diphosphomevalonate decarboxylase; Belongs to the diphosphomevalonate decarboxylase family.	0.832
PDE_00432	PDE_04823	S7Z5V2	S8AUQ2	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.887