(48 nodes) Cellular lipid metabolic process network (Nematocida parisii)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NEQG_02419	Uncharacterized protein. (161 aa)
	NEQG_02396	Phosphatidate cytidylyltransferase. (345 aa)
	NEQG_02261	Biotin carboxylation domain-containing protein. (187 aa)
	NEQG_02262	Uncharacterized protein. (1086 aa)
	NEQG_01844	Saccharopine dehydrogenase. (224 aa)
	NEQG_01932	Uncharacterized protein. (760 aa)
	NEQG_01943	AMP-binding domain-containing protein. (694 aa)
	NEQG_01971	Uncharacterized protein. (270 aa)
	NEQG_01979	Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family. (378 aa)
	NEQG_02020	Uncharacterized protein. (261 aa)
	ALG13	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. (157 aa)
	NEQG_01474	Uncharacterized protein. (265 aa)
	NEQG_01603	SAC domain-containing protein. (569 aa)
	NEQG_01664	PAP2_C domain-containing protein. (275 aa)
	NEQG_01755	LNS2 domain-containing protein. (465 aa)
	NEQG_01055	Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (196 aa)
	NEQG_01073	Uncharacterized protein. (445 aa)
	NEQG_01081	PNPLA domain-containing protein. (912 aa)
	NEQG_01135	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (387 aa)
	NEQG_01325	eIF2A domain-containing protein. (393 aa)
	NEQG_01342	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (373 aa)
	NEQG_00616	1-acyl-sn-glycerol-3-phosphate acyltransferase zeta. (344 aa)
	NEQG_00621	Phosphate cytidylyltransferase 1. (215 aa)
	NEQG_00655	Mannosyltransferase. (579 aa)
	NEQG_00683	Uncharacterized protein. (235 aa)
	NEQG_00728	Hydrolase_4 domain-containing protein. (305 aa)
	NEQG_00732	Uncharacterized protein. (276 aa)
	NEQG_00758	acidPPc domain-containing protein. (242 aa)
	NEQG_00810	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family. (547 aa)
	NEQG_00828	TLC domain-containing protein. (296 aa)
	NEQG_00879	Uncharacterized protein. (337 aa)
	NEQG_00900	Phospholipid:diacylglycerol acyltransferase. (388 aa)
	NEQG_00962	PlsC domain-containing protein. (399 aa)
	NEQG_00963	Lactamase_B domain-containing protein. (499 aa)
	NEQG_01001	Uncharacterized protein. (305 aa)
	NEQG_01010	Elongation of fatty acids protein. (310 aa)
	NEQG_00024	Atypical/PIKK protein kinase; Belongs to the PI3/PI4-kinase family. (1468 aa)
	NEQG_00140	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family. (275 aa)
	NEQG_00150	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis. (397 aa)
	NEQG_00153	Uncharacterized protein. (344 aa)
	NEQG_00240	GP-PDE domain-containing protein. (256 aa)
	NEQG_00242	Uncharacterized protein. (397 aa)
	ALG14	UDP-N-acetylglucosamine transferase subunit ALG14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER. (191 aa)
	NEQG_00295	Uncharacterized protein. (403 aa)
	NEQG_00345	Peptidase_S8 domain-containing protein. (457 aa)
	NEQG_00363	PlsC domain-containing protein. (290 aa)
	NEQG_00413	Uncharacterized protein. (291 aa)
	NEQG_00565	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (194 aa)

Your Current Organism:

Nematocida parisii

NCBI taxonomy Id: 935791
Other names: N. parisii ERTm3, Nematocida parisii ERTm3

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALG13	ALG14	I3EFI0	I3EJX5	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	UDP-N-acetylglucosamine transferase subunit ALG14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.	0.999
ALG13	NEQG_00242	I3EFI0	I3EJS5	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Uncharacterized protein.	0.783
ALG13	NEQG_00413	I3EFI0	I3EK96	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Uncharacterized protein.	0.649
ALG13	NEQG_01073	I3EFI0	I3EGN6	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	Uncharacterized protein.	0.949
ALG14	ALG13	I3EJX5	I3EFI0	UDP-N-acetylglucosamine transferase subunit ALG14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.	UDP-N-acetylglucosamine transferase subunit ALG13; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway.	0.999
ALG14	NEQG_00242	I3EJX5	I3EJS5	UDP-N-acetylglucosamine transferase subunit ALG14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.	Uncharacterized protein.	0.765
ALG14	NEQG_01073	I3EJX5	I3EGN6	UDP-N-acetylglucosamine transferase subunit ALG14; Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.	Uncharacterized protein.	0.953
NEQG_00024	NEQG_00345	I3EJ57	I3EK28	Atypical/PIKK protein kinase; Belongs to the PI3/PI4-kinase family.	Peptidase_S8 domain-containing protein.	0.837
NEQG_00024	NEQG_00565	I3EJ57	I3EKP8	Atypical/PIKK protein kinase; Belongs to the PI3/PI4-kinase family.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.918
NEQG_00024	NEQG_00810	I3EJ57	I3EIE4	Atypical/PIKK protein kinase; Belongs to the PI3/PI4-kinase family.	PI3K/PI4K domain-containing protein; Belongs to the PI3/PI4-kinase family.	0.944
NEQG_00024	NEQG_01325	I3EJ57	I3EHD8	Atypical/PIKK protein kinase; Belongs to the PI3/PI4-kinase family.	eIF2A domain-containing protein.	0.837
NEQG_00024	NEQG_01603	I3EJ57	I3EG12	Atypical/PIKK protein kinase; Belongs to the PI3/PI4-kinase family.	SAC domain-containing protein.	0.950
NEQG_00140	NEQG_00150	I3EJH3	I3EJI3	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	0.567
NEQG_00140	NEQG_00242	I3EJH3	I3EJS5	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Uncharacterized protein.	0.512
NEQG_00140	NEQG_00413	I3EJH3	I3EK96	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Uncharacterized protein.	0.954
NEQG_00140	NEQG_00655	I3EJH3	I3EHY9	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Mannosyltransferase.	0.566
NEQG_00140	NEQG_00683	I3EJH3	I3EI17	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Uncharacterized protein.	0.551
NEQG_00140	NEQG_01932	I3EJH3	I3EF63	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Uncharacterized protein.	0.953
NEQG_00140	NEQG_01979	I3EJH3	I3EFB0	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	Post-GPI attachment to proteins factor 3; Involved in the lipid remodeling steps of GPI-anchor maturation; Belongs to the PGAP3 family.	0.425
NEQG_00150	NEQG_00140	I3EJI3	I3EJH3	GPI mannosyltransferase 2; Mannosyltransferase involved in glycosylphosphatidylinositol- anchor biosynthesis.	GPI-anchor transamidase; Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. Belongs to the peptidase C13 family.	0.567