(69 nodes) Process utilizing autophagic mechanism network (Psilocybe cyanescens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CVT25_011282	t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (281 aa)
	CVT25_004880	Lipase_3 domain-containing protein. (460 aa)
	CVT25_001076	Uncharacterized protein. (1986 aa)
	CVT25_009776	Uncharacterized protein. (673 aa)
	CVT25_012654	Atg29_N domain-containing protein. (397 aa)
	CVT25_006824	Uncharacterized protein. (522 aa)
	CVT25_003094	Protein kinase domain-containing protein. (793 aa)
	CVT25_003107	ATG16 domain-containing protein. (290 aa)
	CVT25_003104	Uncharacterized protein. (203 aa)
	CVT25_006395	Uncharacterized protein; Belongs to the AAA ATPase family. (815 aa)
	CVT25_004477	Protein kinase domain-containing protein. (213 aa)
	CVT25_004476	Protein kinase domain-containing protein. (405 aa)
	CVT25_014051	Uncharacterized protein. (945 aa)
	CVT25_002157	Autophagy-related protein 3. (391 aa)
	CVT25_006147	Uncharacterized protein. (1044 aa)
	CVT25_007023	Uncharacterized protein. (562 aa)
	CVT25_003977	Uncharacterized protein. (742 aa)
	CVT25_003787	CNH domain-containing protein. (992 aa)
	CVT25_014340	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. (652 aa)
	CVT25_015932	Uncharacterized protein. (71 aa)
	CVT25_001730	Atg29_N domain-containing protein. (182 aa)
	CVT25_002974	Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. (391 aa)
	CVT25_003270	PX domain-containing protein. (581 aa)
	CVT25_003419	Uncharacterized protein. (222 aa)
	CVT25_002672	Uncharacterized protein. (1161 aa)
	CVT25_002810	FAS1 domain-containing protein. (122 aa)
	CVT25_010575	ATG11 domain-containing protein. (1381 aa)
	CVT25_011820	Uncharacterized protein. (204 aa)
	CVT25_011846	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily. (941 aa)
	CVT25_011136	AAA domain-containing protein. (659 aa)
	CVT25_011128	DUF202 domain-containing protein. (123 aa)
	CVT25_014431	Protein transport protein sec16; Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy; Belongs to the SEC16 family. (1512 aa)
	CVT25_005742	PX domain-containing protein. (468 aa)
	CVT25_005687	Uncharacterized protein. (888 aa)
	CVT25_014500	Uncharacterized protein. (523 aa)
	CVT25_007595	Uncharacterized protein. (235 aa)
	CVT25_009030	Uncharacterized protein. (394 aa)
	CVT25_004237	PH domain-containing protein. (745 aa)
	CVT25_015220	Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (1004 aa)
	CVT25_000190	Uncharacterized protein. (560 aa)
	CVT25_010325	Uncharacterized protein. (1635 aa)
	CVT25_008928	SPX domain-containing protein. (950 aa)
	CVT25_008931	Lipase_3 domain-containing protein. (446 aa)
	CVT25_008777	Uncharacterized protein. (1732 aa)
	CVT25_007431	Uncharacterized protein. (105 aa)
	CVT25_007459	Vacuolar protein sorting-associated protein 41; Required for vacuolar assembly and vacuolar traffic. Belongs to the VPS41 family. (1030 aa)
	CVT25_008558	Uncharacterized protein; Belongs to the OSBP family. (1241 aa)
	CVT25_011308	Uncharacterized protein. (213 aa)
	CVT25_011340	Uncharacterized protein. (486 aa)
	CVT25_011359	Uncharacterized protein. (143 aa)
	CVT25_010946	WD_REPEATS_REGION domain-containing protein. (462 aa)
	CVT25_010937	t-SNARE coiled-coil homology domain-containing protein. (228 aa)
	CVT25_010846	Autophagy_act_C domain-containing protein. (201 aa)
	CVT25_009760	Uncharacterized protein. (657 aa)
	CVT25_000859	t-SNARE coiled-coil homology domain-containing protein. (234 aa)
	CVT25_004605	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...] (696 aa)
	CVT25_000984	Uncharacterized protein. (175 aa)
	CVT25_001283	CNH domain-containing protein. (378 aa)
	CVT25_014293	Lipase_3 domain-containing protein. (506 aa)
	CVT25_014737	Uncharacterized protein. (418 aa)
	CVT25_013952	ARID domain-containing protein. (1667 aa)
	CVT25_012459	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. (135 aa)
	CVT25_012231	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. (342 aa)
	CVT25_012823	Uncharacterized protein; Belongs to the CTL (choline transporter-like) family. (1275 aa)
	CVT25_003159	Phosphatidylinositol 3-kinase VPS34. (851 aa)
	CVT25_006526	Autophagy-related protein. (127 aa)
	CVT25_010472	Uncharacterized protein. (701 aa)
	CVT25_009466	Mitochondrial fission 1 protein; Has a role in mitochondrial fission. (154 aa)
	CVT25_011536	Autophagy-related protein; Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation; Belongs to the ATG22 family. (608 aa)

Your Current Organism:

Psilocybe cyanescens

NCBI taxonomy Id: 93625
Other names: P. cyanescens, PRM 901481

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT25_000190	CVT25_002672	A0A409XQB6	A0A409WLN6	Uncharacterized protein.	Uncharacterized protein.	0.564
CVT25_000190	CVT25_003094	A0A409XQB6	A0A409X620	Uncharacterized protein.	Protein kinase domain-containing protein.	0.868
CVT25_000190	CVT25_003107	A0A409XQB6	A0A409X4P6	Uncharacterized protein.	ATG16 domain-containing protein.	0.962
CVT25_000190	CVT25_003159	A0A409XQB6	A0A409XEX4	Uncharacterized protein.	Phosphatidylinositol 3-kinase VPS34.	0.802
CVT25_000190	CVT25_004476	A0A409XQB6	A0A409X2H6	Uncharacterized protein.	Protein kinase domain-containing protein.	0.868
CVT25_000190	CVT25_004477	A0A409XQB6	A0A409X2J2	Uncharacterized protein.	Protein kinase domain-containing protein.	0.868
CVT25_000190	CVT25_004605	A0A409XQB6	A0A409VS75	Uncharacterized protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy wh [...]	0.972
CVT25_000190	CVT25_004880	A0A409XQB6	A0A409XBM1	Uncharacterized protein.	Lipase_3 domain-containing protein.	0.853
CVT25_000190	CVT25_006526	A0A409XQB6	A0A409XEK6	Uncharacterized protein.	Autophagy-related protein.	0.976
CVT25_000190	CVT25_008931	A0A409XQB6	A0A409XN77	Uncharacterized protein.	Lipase_3 domain-containing protein.	0.853
CVT25_000190	CVT25_010325	A0A409XQB6	A0A409XNY9	Uncharacterized protein.	Uncharacterized protein.	0.778
CVT25_000190	CVT25_010846	A0A409XQB6	A0A409WFF9	Uncharacterized protein.	Autophagy_act_C domain-containing protein.	0.441
CVT25_000190	CVT25_011846	A0A409XQB6	A0A409WJ05	Uncharacterized protein.	Autophagy-related protein 13; Belongs to the ATG13 family. Fungi subfamily.	0.647
CVT25_000190	CVT25_012231	A0A409XQB6	A0A409XFK4	Uncharacterized protein.	Autophagy protein 5; Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation.	0.971
CVT25_000190	CVT25_012459	A0A409XQB6	A0A409XHC0	Uncharacterized protein.	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy.	0.972
CVT25_000190	CVT25_014293	A0A409XQB6	A0A409XKU3	Uncharacterized protein.	Lipase_3 domain-containing protein.	0.853
CVT25_000190	CVT25_014340	A0A409XQB6	A0A409WU90	Uncharacterized protein.	Cysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.	0.793
CVT25_000190	CVT25_014500	A0A409XQB6	A0A409VP91	Uncharacterized protein.	Uncharacterized protein.	0.880
CVT25_000190	CVT25_014737	A0A409XQB6	A0A409XJY8	Uncharacterized protein.	Uncharacterized protein.	0.866
CVT25_000859	CVT25_001283	A0A409VTF1	A0A409XMA6	t-SNARE coiled-coil homology domain-containing protein.	CNH domain-containing protein.	0.733