(20 nodes) One carbon pool by folate network (Psilocybe cyanescens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CVT25_014421	Uncharacterized protein. (293 aa)
	CVT25_011320	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (623 aa)
	CVT25_011606	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (602 aa)
	CVT25_001970	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family. (205 aa)
	CVT25_013351	Uncharacterized protein. (192 aa)
	CVT25_007204	PNPLA domain-containing protein. (783 aa)
	CVT25_009526	Uncharacterized protein. (641 aa)
	CVT25_005328	SHMT domain-containing protein. (138 aa)
	CVT25_008596	SHMT domain-containing protein. (330 aa)
	CVT25_008648	FSH1 domain-containing protein. (268 aa)
	CVT25_000219	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (358 aa)
	CVT25_011926	Thymidylat_synt domain-containing protein. (308 aa)
	CVT25_014433	Uncharacterized protein. (950 aa)
	CVT25_009740	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (478 aa)
	CVT25_006812	Uncharacterized protein. (413 aa)
	CVT25_005807	Uncharacterized protein. (675 aa)
	CVT25_009459	MGS domain-containing protein. (600 aa)
	CVT25_005881	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (401 aa)
	CVT25_001388	Uncharacterized protein. (355 aa)
	CVT25_006943	Uncharacterized protein. (225 aa)

Your Current Organism:

Psilocybe cyanescens

NCBI taxonomy Id: 93625
Other names: P. cyanescens, PRM 901481

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT25_000219	CVT25_001388	A0A409XQI5	A0A409VPU6	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.991
CVT25_000219	CVT25_001970	A0A409XQI5	A0A409WQN3	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.929
CVT25_000219	CVT25_005328	A0A409XQI5	A0A409XKQ8	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	SHMT domain-containing protein.	0.900
CVT25_000219	CVT25_006812	A0A409XQI5	A0A409X762	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.935
CVT25_000219	CVT25_006943	A0A409XQI5	A0A409VSQ9	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.946
CVT25_000219	CVT25_008596	A0A409XQI5	A0A409XLE1	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	SHMT domain-containing protein.	0.900
CVT25_000219	CVT25_008648	A0A409XQI5	A0A409XNX2	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	FSH1 domain-containing protein.	0.863
CVT25_000219	CVT25_009459	A0A409XQI5	A0A409XD63	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	MGS domain-containing protein.	0.953
CVT25_000219	CVT25_009526	A0A409XQI5	A0A409XDA3	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.900
CVT25_000219	CVT25_009740	A0A409XQI5	A0A409XTQ0	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family.	0.900
CVT25_000219	CVT25_011320	A0A409XQI5	A0A409WGA3	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.941
CVT25_000219	CVT25_011606	A0A409XQI5	A0A409WIP8	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.	0.941
CVT25_000219	CVT25_011926	A0A409XQI5	A0A409XQQ2	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Thymidylat_synt domain-containing protein.	0.901
CVT25_000219	CVT25_014433	A0A409XQI5	A0A409XRG9	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	Uncharacterized protein.	0.963
CVT25_001388	CVT25_000219	A0A409VPU6	A0A409XQI5	Uncharacterized protein.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.991
CVT25_001388	CVT25_001970	A0A409VPU6	A0A409WQN3	Uncharacterized protein.	DHFR domain-containing protein; Belongs to the dihydrofolate reductase family.	0.927
CVT25_001388	CVT25_005328	A0A409VPU6	A0A409XKQ8	Uncharacterized protein.	SHMT domain-containing protein.	0.931
CVT25_001388	CVT25_005807	A0A409VPU6	A0A409XA37	Uncharacterized protein.	Uncharacterized protein.	0.481
CVT25_001388	CVT25_005881	A0A409VPU6	A0A409VM40	Uncharacterized protein.	Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...]	0.629
CVT25_001388	CVT25_006812	A0A409VPU6	A0A409X762	Uncharacterized protein.	Uncharacterized protein.	0.944