Your Input: | |
| | RAD18 | E3 ubiquitin-protein ligase RAD18. (440 aa) |
| | PIEZO1 | Piezo-type mechanosensitive ion channel component. (1905 aa) |
| | ENSEEUP00000000369 | annotation not available (121 aa) |
| | FBH1 | F-box DNA helicase 1 isoform X1. (977 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1311 aa) |
| | ENSEEUP00000000645 | annotation not available (588 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (405 aa) |
| | LOC103128582 | Fanconi anemia core complex-associated protein 24-like. (216 aa) |
| | ENSEEUP00000000900 | annotation not available (548 aa) |
| | POLQ | DNA polymerase theta. (2561 aa) |
| | POLH | DNA polymerase eta. (704 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1130 aa) |
| | BLM | Bloom syndrome protein. (1383 aa) |
| | RAD51B | DNA repair protein RAD51 homolog 2. (344 aa) |
| | ENSEEUP00000001330 | annotation not available (782 aa) |
| | RAD51D | DNA repair protein RAD51 homolog 4 isoform X1. (327 aa) |
| | ENSEEUP00000001566 | annotation not available (497 aa) |
| | RAD51C | DNA repair protein RAD51 homolog 3. (377 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (903 aa) |
| | USP38 | Ubiquitin carboxyl-terminal hydrolase 38 isoform X1; Belongs to the peptidase C19 family. (1024 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | TDRD3 | Tudor domain-containing protein 3. (650 aa) |
| | ENSEEUP00000002022 | annotation not available (356 aa) |
| | RAD51AP1 | RAD51-associated protein 1 isoform X1. (201 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (452 aa) |
| | TIMELESS | Timeless circadian regulator. (1214 aa) |
| | STN1 | STN1 subunit of CST complex. (369 aa) |
| | ENSEEUP00000002093 | annotation not available (1887 aa) |
| | ENSEEUP00000002125 | annotation not available (198 aa) |
| | ENSEEUP00000002216 | annotation not available (543 aa) |
| | RHNO1-2 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (133 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1812 aa) |
| | ENSEEUP00000002522 | annotation not available (706 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (820 aa) |
| | ENSEEUP00000002672 | annotation not available (209 aa) |
| | HELB | DNA helicase B. (1070 aa) |
| | PCNA | Proliferating cell nuclear antigen. (259 aa) |
| | CHD1L | chromodomain-helicase-DNA-binding protein 1-like isoform X1. (873 aa) |
| | ENSEEUP00000002862 | annotation not available (684 aa) |
| | ORC3 | Origin recognition complex subunit 3. (712 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (436 aa) |
| | NUTF2 | Nuclear transport factor 2. (127 aa) |
| | REV3L | DNA polymerase zeta catalytic subunit. (3075 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa) |
| | ERCC8 | DNA excision repair protein ERCC-8. (395 aa) |
| | MCMDC2 | MCM domain-containing protein 2 isoform X2. (590 aa) |
| | DCAKD | dephospho-CoA kinase domain-containing protein. (231 aa) |
| | ENSEEUP00000004392 | annotation not available (410 aa) |
| | GEN1 | Flap endonuclease GEN homolog 1. (871 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (788 aa) |
| | SMARCAL1 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (843 aa) |
| | ENSEEUP00000004813 | annotation not available (1112 aa) |
| | CLSPN | Claspin. (1328 aa) |
| | ENSEEUP00000004885 | annotation not available (315 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1276 aa) |
| | ENSEEUP00000004944 | annotation not available (389 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (611 aa) |
| | DBF4 | Protein DBF4 homolog A. (514 aa) |
| | DCLRE1A | DNA cross-link repair 1A protein. (1003 aa) |
| | FANCM | Fanconi anemia group M protein. (1962 aa) |
| | XPA | DNA repair protein complementing XP-A cells. (214 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (216 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1139 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (835 aa) |
| | ENSEEUP00000005701 | annotation not available (1146 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (466 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1007 aa) |
| | ENSEEUP00000005927 | annotation not available (647 aa) |
| | RAD52 | DNA repair protein RAD52 homolog isoform X1. (391 aa) |
| | CDC45 | Cell division control protein 45 homolog. (481 aa) |
| | MCM8 | DNA helicase MCM8 isoform X1; Belongs to the MCM family. (822 aa) |
| | XRCC3 | DNA repair protein XRCC3 isoform X2. (254 aa) |
| | WDR48 | WD repeat-containing protein 48 isoform X1. (651 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (726 aa) |
| | FAAP20 | Fanconi anemia core complex-associated protein 20. (153 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1 isoform X1. (1452 aa) |
| | ENSEEUP00000006572 | annotation not available (1974 aa) |
| | HES2 | Transcription factor HES-2. (159 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (229 aa) |
| | MCM7 | Minichromosome maintenance complex component 7. (682 aa) |
| | ERCC4 | DNA repair endonuclease XPF. (918 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa) |
| | RAD54B | DNA repair and recombination protein RAD54B. (904 aa) |
| | RAD54L | DNA repair and recombination protein RAD54-like. (747 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (281 aa) |
| | HES5 | Transcription factor HES-5. (160 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (829 aa) |
| | ENSEEUP00000007672 | annotation not available (902 aa) |
| | ENSEEUP00000007680 | annotation not available (700 aa) |
| | LOC107522399 | WD repeat and FYVE domain-containing protein 1-like. (409 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa) |
| | ERCC6 | DNA excision repair protein ERCC-6. (1468 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | EXO1 | Exonuclease 1. (772 aa) |
| | CDT1 | DNA replication factor Cdt1. (541 aa) |
| | ENSEEUP00000007942 | annotation not available (1207 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa) |
| | RADX | Uncharacterized protein CXorf57 homolog. (645 aa) |
| | POLD3 | DNA polymerase delta subunit 3. (404 aa) |
| | MAK | Serine/threonine-protein kinase MAK isoform X2. (623 aa) |
| | TWNK | Twinkle protein, mitochondrial. (682 aa) |
| | RFC3 | Replication factor C subunit 3. (353 aa) |
| | FANCL | E3 ubiquitin-protein ligase FANCL. (372 aa) |
| | CDC7 | Cell division cycle 7-related protein kinase. (483 aa) |
| | ERCC6L2 | LOW QUALITY PROTEIN: DNA excision repair protein ERCC-6-like 2. (708 aa) |
| | ENSEEUP00000008566 | annotation not available (709 aa) |
| | USP46 | Ubiquitin carboxyl-terminal hydrolase 46 isoform X3; Belongs to the peptidase C19 family. (294 aa) |
| | ORC2 | Origin recognition complex subunit 2. (548 aa) |
| | ENSEEUP00000008948 | annotation not available (167 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3345 aa) |
| | RECQL5 | ATP-dependent DNA helicase Q5. (979 aa) |
| | POLE4 | DNA polymerase epsilon subunit 4. (97 aa) |
| | EME1 | Crossover junction endonuclease EME1 isoform X1. (563 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | POLA1 | DNA polymerase alpha 1, catalytic subunit. (1463 aa) |
| | ENSEEUP00000009711 | annotation not available (333 aa) |
| | MCPH1 | Microcephalin isoform X1. (776 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (279 aa) |
| | NEIL3 | Endonuclease 8-like 3. (453 aa) |
| | FANCI | Fanconi anemia group I protein isoform X2. (1228 aa) |
| | RMI1 | recQ-mediated genome instability protein 1. (608 aa) |
| | ENSEEUP00000010090 | annotation not available (245 aa) |
| | POLG | DNA polymerase subunit gamma-1. (1125 aa) |
| | ZRANB3 | DNA annealing helicase and endonuclease ZRANB3 isoform X1. (1000 aa) |
| | UBE2A | Ubiquitin-conjugating enzyme E2 B isoform X1; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | WDR20 | WD repeat-containing protein 20 isoform X2. (554 aa) |
| | BRIP1 | Fanconi anemia group J protein. (1239 aa) |
| | ENSEEUP00000010627 | annotation not available (1121 aa) |
| | ORC5 | Origin recognition complex subunit 5. (420 aa) |
| | WRNIP1 | ATPase WRNIP1 isoform X1. (533 aa) |
| | ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa) |
| | ORC6 | Origin recognition complex subunit 6. (252 aa) |
| | ENSEEUP00000011081 | annotation not available (427 aa) |
| | FANCE | Fanconi anemia group E protein. (503 aa) |
| | NARS1 | asparagine--tRNA ligase, cytoplasmic isoform X1. (548 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (943 aa) |
| | ENSEEUP00000011189 | annotation not available (1002 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (797 aa) |
| | WDR76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (604 aa) |
| | ENSEEUP00000011399 | annotation not available (197 aa) |
| | ENSEEUP00000011467 | annotation not available (851 aa) |
| | POLE3 | DNA polymerase epsilon subunit 3. (147 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1813 aa) |
| | ENSEEUP00000011645 | annotation not available (1440 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1 isoform X2. (232 aa) |
| | PMS1 | PMS1 protein homolog 1 isoform X6. (931 aa) |
| | RFC5 | Replication factor C subunit 5. (304 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1011 aa) |
| | PRIMPOL | DNA-directed primase/polymerase protein isoform X1. (549 aa) |
| | MLH3 | DNA mismatch repair protein Mlh3 isoform X1. (1403 aa) |
| | FANCD2 | Fanconi anemia group D2 protein. (1462 aa) |
| | PMS2 | Mismatch repair endonuclease PMS2. (845 aa) |
| | ENSEEUP00000012980 | annotation not available (357 aa) |
| | DMC1 | Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (323 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (279 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (516 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein. (214 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (144 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (536 aa) |
| | POLI | DNA polymerase iota. (383 aa) |
| | XPC | DNA repair protein complementing XP-C cells. (912 aa) |
| | ENSEEUP00000013883 | annotation not available (218 aa) |
| | PALB2 | Partner and localizer of BRCA2 isoform X2. (1173 aa) |
| | HLTF | Helicase-like transcription factor isoform X2. (1009 aa) |
| | SLF1 | LOW QUALITY PROTEIN: SMC5-SMC6 complex localization factor protein 1. (1057 aa) |
| | MUS81 | Crossover junction endonuclease MUS81 isoform X3. (464 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (553 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (509 aa) |
