STRINGSTRING
ENSEEUP00000000369 ENSEEUP00000000369 FBH1 FBH1 RAD50 RAD50 POLH POLH WDHD1 WDHD1 BLM BLM RAD51B RAD51B ENSEEUP00000001330 ENSEEUP00000001330 RAD51D RAD51D RAD51C RAD51C RBBP8 RBBP8 RPA1 RPA1 TDRD3 TDRD3 ENSEEUP00000002022 ENSEEUP00000002022 RAD51AP1 RAD51AP1 PRIM2 PRIM2 STN1 STN1 ENSEEUP00000002093 ENSEEUP00000002093 ENSEEUP00000002216 ENSEEUP00000002216 RHNO1-2 RHNO1-2 BRCA1 BRCA1 PCNA PCNA ENSEEUP00000002862 ENSEEUP00000002862 PIF1 PIF1 REV3L REV3L CHEK1 CHEK1 ENSEEUP00000004392 ENSEEUP00000004392 GEN1 GEN1 WRN WRN ENSEEUP00000004813 ENSEEUP00000004813 CLSPN CLSPN ENSEEUP00000004885 ENSEEUP00000004885 RTEL1 RTEL1 BARD1 BARD1 FANCM FANCM MAD2L2 MAD2L2 MSH6 MSH6 ENSEEUP00000005701 ENSEEUP00000005701 POLD2 POLD2 ENSEEUP00000005927 ENSEEUP00000005927 RAD52 RAD52 XRCC3 XRCC3 TOPBP1 TOPBP1 ENSEEUP00000006572 ENSEEUP00000006572 RHNO1 RHNO1 ATM ATM RAD1 RAD1 ENSEEUP00000007680 ENSEEUP00000007680 MRE11 MRE11 RFC4 RFC4 EXO1 EXO1 ENSEEUP00000007942 ENSEEUP00000007942 DNA2 DNA2 POLD3 POLD3 RFC3 RFC3 ENSEEUP00000008566 ENSEEUP00000008566 BRCA2 BRCA2 RECQL5 RECQL5 POLE4 POLE4 POLA1 POLA1 ENSEEUP00000009711 ENSEEUP00000009711 MCPH1 MCPH1 HUS1 HUS1 RMI1 RMI1 BRIP1 BRIP1 ENSEEUP00000010627 ENSEEUP00000010627 ATR ATR ENSEEUP00000011081 ENSEEUP00000011081 TOP3A TOP3A POLE3 POLE3 ATAD5 ATAD5 PMS1 PMS1 RFC5 RFC5 REV1 REV1 MLH3 MLH3 PMS2 PMS2 DMC1 DMC1 DSCC1 DSCC1 POLE2 POLE2 MEIOB MEIOB POLI POLI PALB2 PALB2 SLF1 SLF1 MSH2 MSH2 NBN NBN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSEEUP00000000369annotation not available (121 aa)
FBH1F-box DNA helicase 1 isoform X1. (977 aa)
RAD50DNA repair protein RAD50 isoform X1. (1311 aa)
POLHDNA polymerase eta. (704 aa)
WDHD1WD repeat and HMG-box DNA binding protein 1. (1130 aa)
BLMBloom syndrome protein. (1383 aa)
RAD51BDNA repair protein RAD51 homolog 2. (344 aa)
ENSEEUP00000001330annotation not available (782 aa)
RAD51DDNA repair protein RAD51 homolog 4 isoform X1. (327 aa)
RAD51CDNA repair protein RAD51 homolog 3. (377 aa)
RBBP8DNA endonuclease RBBP8. (903 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
TDRD3Tudor domain-containing protein 3. (650 aa)
ENSEEUP00000002022annotation not available (356 aa)
RAD51AP1RAD51-associated protein 1 isoform X1. (201 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (452 aa)
STN1STN1 subunit of CST complex. (369 aa)
ENSEEUP00000002093annotation not available (1887 aa)
ENSEEUP00000002216annotation not available (543 aa)
RHNO1-2RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (133 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1812 aa)
PCNAProliferating cell nuclear antigen. (259 aa)
ENSEEUP00000002862annotation not available (684 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (436 aa)
REV3LDNA polymerase zeta catalytic subunit. (3075 aa)
CHEK1Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
ENSEEUP00000004392annotation not available (410 aa)
GEN1Flap endonuclease GEN homolog 1. (871 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa)
ENSEEUP00000004813annotation not available (1112 aa)
CLSPNClaspin. (1328 aa)
ENSEEUP00000004885annotation not available (315 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1276 aa)
BARD1BRCA1-associated RING domain protein 1. (611 aa)
FANCMFanconi anemia group M protein. (1962 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (216 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1139 aa)
ENSEEUP00000005701annotation not available (1146 aa)
POLD2DNA polymerase delta subunit 2. (466 aa)
ENSEEUP00000005927annotation not available (647 aa)
RAD52DNA repair protein RAD52 homolog isoform X1. (391 aa)
XRCC3DNA repair protein XRCC3 isoform X2. (254 aa)
TOPBP1DNA topoisomerase 2-binding protein 1 isoform X1. (1452 aa)
ENSEEUP00000006572annotation not available (1974 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (229 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
ENSEEUP00000007680annotation not available (700 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa)
RFC4Replication factor C subunit 4. (363 aa)
EXO1Exonuclease 1. (772 aa)
ENSEEUP00000007942annotation not available (1207 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa)
POLD3DNA polymerase delta subunit 3. (404 aa)
RFC3Replication factor C subunit 3. (353 aa)
ENSEEUP00000008566annotation not available (709 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3345 aa)
RECQL5ATP-dependent DNA helicase Q5. (979 aa)
POLE4DNA polymerase epsilon subunit 4. (97 aa)
POLA1DNA polymerase alpha 1, catalytic subunit. (1463 aa)
ENSEEUP00000009711annotation not available (333 aa)
MCPH1Microcephalin isoform X1. (776 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (279 aa)
RMI1recQ-mediated genome instability protein 1. (608 aa)
BRIP1Fanconi anemia group J protein. (1239 aa)
ENSEEUP00000010627annotation not available (1121 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa)
ENSEEUP00000011081annotation not available (427 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (943 aa)
POLE3DNA polymerase epsilon subunit 3. (147 aa)
ATAD5ATPase family AAA domain containing 5. (1813 aa)
PMS1PMS1 protein homolog 1 isoform X6. (931 aa)
RFC5Replication factor C subunit 5. (304 aa)
REV1DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1011 aa)
MLH3DNA mismatch repair protein Mlh3 isoform X1. (1403 aa)
PMS2Mismatch repair endonuclease PMS2. (845 aa)
DMC1Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (323 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (279 aa)
POLE2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (516 aa)
MEIOBMeiosis-specific with OB domain-containing protein. (214 aa)
POLIDNA polymerase iota. (383 aa)
PALB2Partner and localizer of BRCA2 isoform X2. (1173 aa)
SLF1LOW QUALITY PROTEIN: SMC5-SMC6 complex localization factor protein 1. (1057 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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