52 items (Erinaceus europaeus) - STRING interaction network

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ENSEEUP00000000369	annotation not available (121 aa)
	FBH1	F-box DNA helicase 1 isoform X1. (977 aa)
	RAD50	DNA repair protein RAD50 isoform X1. (1311 aa)
	WDHD1	WD repeat and HMG-box DNA binding protein 1. (1130 aa)
	BLM	Bloom syndrome protein. (1383 aa)
	RAD51B	DNA repair protein RAD51 homolog 2. (344 aa)
	ENSEEUP00000001330	annotation not available (782 aa)
	RAD51D	DNA repair protein RAD51 homolog 4 isoform X1. (327 aa)
	RAD51C	DNA repair protein RAD51 homolog 3. (377 aa)
	RBBP8	DNA endonuclease RBBP8. (903 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	TDRD3	Tudor domain-containing protein 3. (650 aa)
	RAD51AP1	RAD51-associated protein 1 isoform X1. (201 aa)
	ENSEEUP00000002216	annotation not available (543 aa)
	RHNO1-2	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (133 aa)
	BRCA1	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1812 aa)
	PIF1	ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (436 aa)
	CHEK1	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
	ENSEEUP00000004392	annotation not available (410 aa)
	GEN1	Flap endonuclease GEN homolog 1. (871 aa)
	WRN	LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa)
	ENSEEUP00000004813	annotation not available (1112 aa)
	CLSPN	Claspin. (1328 aa)
	RTEL1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1276 aa)
	BARD1	BRCA1-associated RING domain protein 1. (611 aa)
	FANCM	Fanconi anemia group M protein. (1962 aa)
	RAD52	DNA repair protein RAD52 homolog isoform X1. (391 aa)
	XRCC3	DNA repair protein XRCC3 isoform X2. (254 aa)
	TOPBP1	DNA topoisomerase 2-binding protein 1 isoform X1. (1452 aa)
	ENSEEUP00000006572	annotation not available (1974 aa)
	RHNO1	RAD9-HUS1-RAD1 interacting nuclear orphan 1. (229 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
	RAD1	Cell cycle checkpoint protein RAD1. (281 aa)
	MRE11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa)
	EXO1	Exonuclease 1. (772 aa)
	DNA2	DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa)
	ENSEEUP00000008566	annotation not available (709 aa)
	BRCA2	Breast cancer type 2 susceptibility protein. (3345 aa)
	RECQL5	ATP-dependent DNA helicase Q5. (979 aa)
	ENSEEUP00000009711	annotation not available (333 aa)
	MCPH1	Microcephalin isoform X1. (776 aa)
	HUS1	Checkpoint protein; Belongs to the HUS1 family. (279 aa)
	RMI1	recQ-mediated genome instability protein 1. (608 aa)
	BRIP1	Fanconi anemia group J protein. (1239 aa)
	ATR	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa)
	TOP3A	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (943 aa)
	ATAD5	ATPase family AAA domain containing 5. (1813 aa)
	DMC1	Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (323 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein. (214 aa)
	PALB2	Partner and localizer of BRCA2 isoform X2. (1173 aa)
	SLF1	LOW QUALITY PROTEIN: SMC5-SMC6 complex localization factor protein 1. (1057 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	ATM	ENSEEUP00000011589	ENSEEUP00000007164	ATPase family AAA domain containing 5.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.683
ATAD5	ATR	ENSEEUP00000011589	ENSEEUP00000010962	ATPase family AAA domain containing 5.	Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family.	0.462
ATAD5	BARD1	ENSEEUP00000011589	ENSEEUP00000004965	ATPase family AAA domain containing 5.	BRCA1-associated RING domain protein 1.	0.730
ATAD5	BLM	ENSEEUP00000011589	ENSEEUP00000001297	ATPase family AAA domain containing 5.	Bloom syndrome protein.	0.897
ATAD5	BRCA1	ENSEEUP00000011589	ENSEEUP00000002494	ATPase family AAA domain containing 5.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.696
ATAD5	BRCA2	ENSEEUP00000011589	ENSEEUP00000008968	ATPase family AAA domain containing 5.	Breast cancer type 2 susceptibility protein.	0.685
ATAD5	BRIP1	ENSEEUP00000011589	ENSEEUP00000010572	ATPase family AAA domain containing 5.	Fanconi anemia group J protein.	0.684
ATAD5	CHEK1	ENSEEUP00000011589	ENSEEUP00000003254	ATPase family AAA domain containing 5.	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	0.515
ATAD5	CLSPN	ENSEEUP00000011589	ENSEEUP00000004857	ATPase family AAA domain containing 5.	Claspin.	0.858
ATAD5	DMC1	ENSEEUP00000011589	ENSEEUP00000013011	ATPase family AAA domain containing 5.	Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family.	0.697
ATAD5	DNA2	ENSEEUP00000011589	ENSEEUP00000008021	ATPase family AAA domain containing 5.	DNA replication ATP-dependent helicase/nuclease DNA2.	0.890
ATAD5	ENSEEUP00000000369	ENSEEUP00000011589	ENSEEUP00000000369	ATPase family AAA domain containing 5.	annotation not available	0.694
ATAD5	ENSEEUP00000002216	ENSEEUP00000011589	ENSEEUP00000002216	ATPase family AAA domain containing 5.	annotation not available	0.591
ATAD5	ENSEEUP00000004392	ENSEEUP00000011589	ENSEEUP00000004392	ATPase family AAA domain containing 5.	annotation not available	0.728
ATAD5	ENSEEUP00000004813	ENSEEUP00000011589	ENSEEUP00000004813	ATPase family AAA domain containing 5.	annotation not available	0.914
ATAD5	ENSEEUP00000008566	ENSEEUP00000011589	ENSEEUP00000008566	ATPase family AAA domain containing 5.	annotation not available	0.593
ATAD5	ENSEEUP00000009711	ENSEEUP00000011589	ENSEEUP00000009711	ATPase family AAA domain containing 5.	annotation not available	0.598
ATAD5	EXO1	ENSEEUP00000011589	ENSEEUP00000007880	ATPase family AAA domain containing 5.	Exonuclease 1.	0.947
ATAD5	FANCM	ENSEEUP00000011589	ENSEEUP00000005163	ATPase family AAA domain containing 5.	Fanconi anemia group M protein.	0.864
ATAD5	FBH1	ENSEEUP00000011589	ENSEEUP00000000409	ATPase family AAA domain containing 5.	F-box DNA helicase 1 isoform X1.	0.671