STRINGSTRING
ENSEEUP00000000369 ENSEEUP00000000369 BLM BLM RPA1 RPA1 WRN WRN FANCM FANCM RAD52 RAD52 ENSEEUP00000009711 ENSEEUP00000009711 RMI1 RMI1 TOP3A TOP3A MEIOB MEIOB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSEEUP00000000369annotation not available (121 aa)
BLMBloom syndrome protein. (1383 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa)
FANCMFanconi anemia group M protein. (1962 aa)
RAD52DNA repair protein RAD52 homolog isoform X1. (391 aa)
ENSEEUP00000009711annotation not available (333 aa)
RMI1recQ-mediated genome instability protein 1. (608 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (943 aa)
MEIOBMeiosis-specific with OB domain-containing protein. (214 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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