(5 nodes) impB/mucB/samB family, and Zeta DNA polymerase complex network (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	POLH	DNA polymerase eta. (704 aa)
	REV3L	DNA polymerase zeta catalytic subunit. (3075 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (216 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1011 aa)
	POLI	DNA polymerase iota. (383 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MAD2L2	POLH	ENSEEUP00000005386	ENSEEUP00000001030	Mitotic spindle assembly checkpoint protein MAD2B.	DNA polymerase eta.	0.960
MAD2L2	POLI	ENSEEUP00000005386	ENSEEUP00000013587	Mitotic spindle assembly checkpoint protein MAD2B.	DNA polymerase iota.	0.957
MAD2L2	REV1	ENSEEUP00000005386	ENSEEUP00000012337	Mitotic spindle assembly checkpoint protein MAD2B.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.995
MAD2L2	REV3L	ENSEEUP00000005386	ENSEEUP00000003247	Mitotic spindle assembly checkpoint protein MAD2B.	DNA polymerase zeta catalytic subunit.	0.999
POLH	MAD2L2	ENSEEUP00000001030	ENSEEUP00000005386	DNA polymerase eta.	Mitotic spindle assembly checkpoint protein MAD2B.	0.960
POLH	POLI	ENSEEUP00000001030	ENSEEUP00000013587	DNA polymerase eta.	DNA polymerase iota.	0.744
POLH	REV1	ENSEEUP00000001030	ENSEEUP00000012337	DNA polymerase eta.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.984
POLH	REV3L	ENSEEUP00000001030	ENSEEUP00000003247	DNA polymerase eta.	DNA polymerase zeta catalytic subunit.	0.989
POLI	MAD2L2	ENSEEUP00000013587	ENSEEUP00000005386	DNA polymerase iota.	Mitotic spindle assembly checkpoint protein MAD2B.	0.957
POLI	POLH	ENSEEUP00000013587	ENSEEUP00000001030	DNA polymerase iota.	DNA polymerase eta.	0.744
POLI	REV1	ENSEEUP00000013587	ENSEEUP00000012337	DNA polymerase iota.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.971
POLI	REV3L	ENSEEUP00000013587	ENSEEUP00000003247	DNA polymerase iota.	DNA polymerase zeta catalytic subunit.	0.952
REV1	MAD2L2	ENSEEUP00000012337	ENSEEUP00000005386	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	Mitotic spindle assembly checkpoint protein MAD2B.	0.995
REV1	POLH	ENSEEUP00000012337	ENSEEUP00000001030	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	DNA polymerase eta.	0.984
REV1	POLI	ENSEEUP00000012337	ENSEEUP00000013587	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	DNA polymerase iota.	0.971
REV1	REV3L	ENSEEUP00000012337	ENSEEUP00000003247	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	DNA polymerase zeta catalytic subunit.	0.988
REV3L	MAD2L2	ENSEEUP00000003247	ENSEEUP00000005386	DNA polymerase zeta catalytic subunit.	Mitotic spindle assembly checkpoint protein MAD2B.	0.999
REV3L	POLH	ENSEEUP00000003247	ENSEEUP00000001030	DNA polymerase zeta catalytic subunit.	DNA polymerase eta.	0.989
REV3L	POLI	ENSEEUP00000003247	ENSEEUP00000013587	DNA polymerase zeta catalytic subunit.	DNA polymerase iota.	0.952
REV3L	REV1	ENSEEUP00000003247	ENSEEUP00000012337	DNA polymerase zeta catalytic subunit.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.988