STRINGSTRING
MPV17 MPV17 TYMP TYMP PIF1 PIF1 SLC25A36 SLC25A36 ENSEEUP00000006070 ENSEEUP00000006070 OPA1 OPA1 MEF2A MEF2A ENSEEUP00000007037 ENSEEUP00000007037 DNA2 DNA2 TWNK TWNK LIG3 LIG3 SSBP1 SSBP1 RRM1 RRM1 POLG POLG SLC25A33 SLC25A33 TOP3A TOP3A PARP1 PARP1 PRIMPOL PRIMPOL TP53 TP53
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
MPV17Mitochondrial inner membrane protein MPV17. (147 aa)
TYMPThymidine phosphorylase; Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (243 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (436 aa)
SLC25A36Solute carrier family 25 member 36 isoform X2; Belongs to the mitochondrial carrier (TC 2.A.29) family. (310 aa)
ENSEEUP00000006070annotation not available (342 aa)
OPA1Dynamin-like 120 kDa protein, mitochondrial isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (989 aa)
MEF2AMyocyte-specific enhancer factor 2A isoform X3. (488 aa)
ENSEEUP00000007037annotation not available (284 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa)
TWNKTwinkle protein, mitochondrial. (682 aa)
LIG3DNA ligase. (708 aa)
SSBP1Single-stranded DNA-binding protein, mitochondrial. (147 aa)
RRM1Ribonucleotide reductase catalytic subunit M1. (792 aa)
POLGDNA polymerase subunit gamma-1. (1125 aa)
SLC25A33Solute carrier family 25 member 33; Belongs to the mitochondrial carrier (TC 2.A.29) family. (302 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (943 aa)
PARP1Poly [ADP-ribose] polymerase. (1016 aa)
PRIMPOLDNA-directed primase/polymerase protein isoform X1. (549 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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