STRINGSTRING
ACD ACD BRCA2 BRCA2 INO80 INO80 ENSEEUP00000008832 ENSEEUP00000008832 TERF1 TERF1 ENSEEUP00000008137 ENSEEUP00000008137 DNA2 DNA2 FBXO4 FBXO4 ENSEEUP00000007942 ENSEEUP00000007942 MRE11 MRE11 ATM ATM ERCC4 ERCC4 PRKDC PRKDC ENSEEUP00000006577 ENSEEUP00000006577 ENSEEUP00000006554 ENSEEUP00000006554 PTGES3 PTGES3 XRCC3 XRCC3 DCLRE1A DCLRE1A XRCC5 XRCC5 ENSEEUP00000004813 ENSEEUP00000004813 WRN WRN GAR1 GAR1 ENSEEUP00000003518 ENSEEUP00000003518 PIF1 PIF1 DKC1 DKC1 PCNA PCNA ENSEEUP00000002783 ENSEEUP00000002783 STN1 STN1 RPA1 RPA1 CCNE2 CCNE2 MCRS1 MCRS1 NSMCE2 NSMCE2 CCNE1 CCNE1 PARP3 PARP3 RAD50 RAD50 RAD51D RAD51D BLM BLM RAD51C RAD51C ENSEEUP00000000207 ENSEEUP00000000207 NBN NBN SLX4 SLX4 TPRKB TPRKB ZBTB48 ZBTB48 XRCC1 XRCC1 WRAP53 WRAP53 SMC6 SMC6 SMC5 SMC5 ACTR8 ACTR8 NFRKB NFRKB RIF1 RIF1 ERCC1 ERCC1 APEX1 APEX1 TEP1 TEP1 RUVBL1 RUVBL1 ATR ATR ENSEEUP00000010729 ENSEEUP00000010729 INO80D INO80D ENSEEUP00000009948 ENSEEUP00000009948 HUS1 HUS1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ACDAdrenocortical dysplasia protein homolog isoform X1. (528 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3345 aa)
INO80DNA helicase INO80. (1532 aa)
ENSEEUP00000008832annotation not available (514 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa)
ENSEEUP00000008137annotation not available (338 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa)
FBXO4F-box only protein 4. (324 aa)
ENSEEUP00000007942annotation not available (1207 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
ERCC4DNA repair endonuclease XPF. (918 aa)
PRKDCDNA-dependent protein kinase catalytic subunit. (4126 aa)
ENSEEUP00000006577annotation not available (598 aa)
ENSEEUP00000006554annotation not available (397 aa)
PTGES3Prostaglandin E synthase 3 isoform X1. (159 aa)
XRCC3DNA repair protein XRCC3 isoform X2. (254 aa)
DCLRE1ADNA cross-link repair 1A protein. (1003 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (625 aa)
ENSEEUP00000004813annotation not available (1112 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (223 aa)
ENSEEUP00000003518annotation not available (658 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (436 aa)
DKC1H/ACA ribonucleoprotein complex subunit 4 isoform X1. (424 aa)
PCNAProliferating cell nuclear antigen. (259 aa)
ENSEEUP00000002783annotation not available (944 aa)
STN1STN1 subunit of CST complex. (369 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
CCNE2G1/S-specific cyclin-E2 isoform X2; Belongs to the cyclin family. (403 aa)
MCRS1Microspherule protein 1. (458 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (208 aa)
CCNE1LOW QUALITY PROTEIN: G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
PARP3Poly [ADP-ribose] polymerase. (536 aa)
RAD50DNA repair protein RAD50 isoform X1. (1311 aa)
RAD51DDNA repair protein RAD51 homolog 4 isoform X1. (327 aa)
BLMBloom syndrome protein. (1383 aa)
RAD51CDNA repair protein RAD51 homolog 3. (377 aa)
ENSEEUP00000000207annotation not available (294 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
SLX4Structure-specific endonuclease subunit SLX4. (1553 aa)
TPRKBEKC/KEOPS complex subunit TPRKB; Belongs to the CGI121/TPRKB family. (147 aa)
ZBTB48Zinc finger and BTB domain-containing protein 48 isoform X1. (688 aa)
XRCC1DNA repair protein XRCC1 isoform X2. (631 aa)
WRAP53WD repeat containing antisense to TP53. (529 aa)
SMC6Structural maintenance of chromosomes protein 6. (1047 aa)
SMC5Structural maintenance of chromosomes protein 5. (1093 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (577 aa)
NFRKBNuclear factor related to kappa-B-binding protein. (1319 aa)
RIF1Replication timing regulatory factor 1. (2367 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X2. (232 aa)
APEX1DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (288 aa)
TEP1Telomerase associated protein 1. (2614 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (338 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa)
ENSEEUP00000010729annotation not available (447 aa)
INO80DINO80 complex subunit D. (876 aa)
ENSEEUP00000009948annotation not available (317 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (279 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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