(55 nodes) Regulation of double-strand break repair via homologous recombination network (Erinaceus europaeus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	VPS72	Vacuolar protein sorting-associated protein 72 homolog. (364 aa)
	FBH1	F-box DNA helicase 1 isoform X1. (977 aa)
	EP400	E1A-binding protein p400. (2972 aa)
	SETD2	SET domain containing 2, histone lysine methyltransferase. (2060 aa)
	TEX15	Testis-expressed sequence 15 protein. (2748 aa)
	POLQ	DNA polymerase theta. (2561 aa)
	ARID2	AT-rich interactive domain-containing protein 2 isoform X1. (1766 aa)
	RBBP8	DNA endonuclease RBBP8. (903 aa)
	RAD51AP1	RAD51-associated protein 1 isoform X1. (201 aa)
	TIMELESS	Timeless circadian regulator. (1214 aa)
	HELB	DNA helicase B. (1070 aa)
	YEATS4	YEATS domain-containing protein 4 isoform X1. (227 aa)
	CHEK1	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa)
	POGZ	Pogo transposable element with ZNF domain isoform X3. (1318 aa)
	ENSEEUP00000003620	annotation not available (206 aa)
	FUS	RNA-binding protein FUS isoform X1. (519 aa)
	KLHL15	Kelch-like protein 15 isoform X2. (425 aa)
	WAS	wiskott-Aldrich syndrome protein. (503 aa)
	MMS19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1028 aa)
	MORF4L2	Mortality factor 4-like protein 2. (289 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (216 aa)
	BRD8	Bromodomain-containing protein 8 isoform X1. (1229 aa)
	SMCHD1	Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1290 aa)
	DMAP1	DNA methyltransferase 1-associated protein 1 isoform X1. (472 aa)
	SPIDR	DNA repair-scaffolding protein. (892 aa)
	KDM1A	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (872 aa)
	WDR48	WD repeat-containing protein 48 isoform X1. (651 aa)
	ENSEEUP00000006554	annotation not available (397 aa)
	ENSEEUP00000006572	annotation not available (1974 aa)
	EPC1	Enhancer of polycomb homolog. (804 aa)
	PARPBP	PCNA-interacting partner. (500 aa)
	ENSEEUP00000007672	annotation not available (902 aa)
	ERCC6	DNA excision repair protein ERCC-6. (1468 aa)
	ENSEEUP00000007939	annotation not available (84 aa)
	RADX	Uncharacterized protein CXorf57 homolog. (645 aa)
	FIGNL1	Fidgetin-like protein 1; Belongs to the AAA ATPase family. (677 aa)
	ENSEEUP00000008743	annotation not available (183 aa)
	MB21D1	Cyclic GMP-AMP synthase. (296 aa)
	RECQL5	ATP-dependent DNA helicase Q5. (979 aa)
	LOC103117148	UPF0544 protein C5orf45 homolog. (301 aa)
	RUVBL1	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (338 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1016 aa)
	ENSEEUP00000011377	annotation not available (827 aa)
	ENSEEUP00000011467	annotation not available (851 aa)
	PPP4C	Serine/threonine-protein phosphatase. (307 aa)
	ING3	Inhibitor of growth protein. (380 aa)
	ENSEEUP00000011699	annotation not available (481 aa)
	RIF1	Replication timing regulatory factor 1. (2367 aa)
	ENSEEUP00000012233	annotation not available (301 aa)
	NSMCE3	Non-structural maintenance of chromosomes element 3 homolog. (286 aa)
	EPC2	Enhancer of polycomb homolog. (735 aa)
	MEAF6	Chromatin modification-related protein MEAF6. (171 aa)
	MRGBP	MRG/MORF4L-binding protein. (153 aa)
	WRAP53	WD repeat containing antisense to TP53. (529 aa)
	MBTD1	MBT domain-containing protein 1 isoform X2. (577 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRD8	DMAP1	ENSEEUP00000005520	ENSEEUP00000005863	Bromodomain-containing protein 8 isoform X1.	DNA methyltransferase 1-associated protein 1 isoform X1.	0.934
BRD8	ENSEEUP00000011699	ENSEEUP00000005520	ENSEEUP00000011699	Bromodomain-containing protein 8 isoform X1.	annotation not available	0.938
BRD8	EP400	ENSEEUP00000005520	ENSEEUP00000000581	Bromodomain-containing protein 8 isoform X1.	E1A-binding protein p400.	0.908
BRD8	EPC1	ENSEEUP00000005520	ENSEEUP00000007093	Bromodomain-containing protein 8 isoform X1.	Enhancer of polycomb homolog.	0.825
BRD8	EPC2	ENSEEUP00000005520	ENSEEUP00000012638	Bromodomain-containing protein 8 isoform X1.	Enhancer of polycomb homolog.	0.850
BRD8	ERCC6	ENSEEUP00000005520	ENSEEUP00000007796	Bromodomain-containing protein 8 isoform X1.	DNA excision repair protein ERCC-6.	0.462
BRD8	ING3	ENSEEUP00000005520	ENSEEUP00000011677	Bromodomain-containing protein 8 isoform X1.	Inhibitor of growth protein.	0.887
BRD8	MBTD1	ENSEEUP00000005520	ENSEEUP00000014138	Bromodomain-containing protein 8 isoform X1.	MBT domain-containing protein 1 isoform X2.	0.636
BRD8	MEAF6	ENSEEUP00000005520	ENSEEUP00000012728	Bromodomain-containing protein 8 isoform X1.	Chromatin modification-related protein MEAF6.	0.924
BRD8	MORF4L2	ENSEEUP00000005520	ENSEEUP00000005345	Bromodomain-containing protein 8 isoform X1.	Mortality factor 4-like protein 2.	0.923
BRD8	MRGBP	ENSEEUP00000005520	ENSEEUP00000013290	Bromodomain-containing protein 8 isoform X1.	MRG/MORF4L-binding protein.	0.974
BRD8	RUVBL1	ENSEEUP00000005520	ENSEEUP00000011162	Bromodomain-containing protein 8 isoform X1.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.963
BRD8	VPS72	ENSEEUP00000005520	ENSEEUP00000000279	Bromodomain-containing protein 8 isoform X1.	Vacuolar protein sorting-associated protein 72 homolog.	0.916
BRD8	YEATS4	ENSEEUP00000005520	ENSEEUP00000002849	Bromodomain-containing protein 8 isoform X1.	YEATS domain-containing protein 4 isoform X1.	0.930
CHEK1	ENSEEUP00000006572	ENSEEUP00000003254	ENSEEUP00000006572	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	annotation not available	0.954
CHEK1	ENSEEUP00000011699	ENSEEUP00000003254	ENSEEUP00000011699	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	annotation not available	0.650
CHEK1	PPP4C	ENSEEUP00000003254	ENSEEUP00000011648	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	Serine/threonine-protein phosphatase.	0.462
CHEK1	RAD51AP1	ENSEEUP00000003254	ENSEEUP00000002051	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	RAD51-associated protein 1 isoform X1.	0.416
CHEK1	RBBP8	ENSEEUP00000003254	ENSEEUP00000001755	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	DNA endonuclease RBBP8.	0.754
CHEK1	RECQL5	ENSEEUP00000003254	ENSEEUP00000009070	Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily.	ATP-dependent DNA helicase Q5.	0.719