STRINGSTRING
ENSEEUP00000012623 ENSEEUP00000012623 CDRT1 CDRT1 EIF3E EIF3E SMC5 SMC5 TP53 TP53 SMC6 SMC6 MORC3 MORC3 ATR ATR ENSEEUP00000010901 ENSEEUP00000010901 RB1 RB1 NSMCE2 NSMCE2 KAT6A KAT6A CALCOCO2 CALCOCO2 BLM BLM TP53INP1 TP53INP1 RPA1 RPA1 ENSEEUP00000002216 ENSEEUP00000002216 TOP3A TOP3A PARK7 PARK7 TP73 TP73 CHD3 CHD3 ENSEEUP00000013950 ENSEEUP00000013950 PIAS1 PIAS1 HIPK3 HIPK3 IKBKE IKBKE TRIM16 TRIM16 THAP1 THAP1 ENSEEUP00000003840 ENSEEUP00000003840 TRIM8 TRIM8 SQSTM1 SQSTM1 NBN NBN CDK9 CDK9 SIRT1 SIRT1 KLHL20 KLHL20 PIAS2 PIAS2 ENSEEUP00000006339 ENSEEUP00000006339 TOPBP1 TOPBP1 RPAIN RPAIN TP53INP2 TP53INP2 ENSEEUP00000007055 ENSEEUP00000007055 N4BP1 N4BP1 MRE11 MRE11 ENSEEUP00000007762 ENSEEUP00000007762 PPARGC1A PPARGC1A ZBTB16 ZBTB16 HIPK1 HIPK1 WDFY3 WDFY3 CASP8AP2 CASP8AP2 ENSEEUP00000009429 ENSEEUP00000009429 RNF111 RNF111 SATB1 SATB1 ENSEEUP00000009680 ENSEEUP00000009680 TDP2 TDP2 RNF4 RNF4 TOPORS TOPORS ZMYM2 ZMYM2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSEEUP00000012623annotation not available (680 aa)
CDRT1CMT1A duplicated region transcript 1 protein. (724 aa)
EIF3EEukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (284 aa)
SMC5Structural maintenance of chromosomes protein 5. (1093 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
SMC6Structural maintenance of chromosomes protein 6. (1047 aa)
MORC3MORC family CW-type zinc finger protein 3 isoform X1. (938 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa)
ENSEEUP00000010901annotation not available (458 aa)
RB1Retinoblastoma-associated protein. (928 aa)
NSMCE2E3 SUMO-protein ligase NSE2. (208 aa)
KAT6AHistone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (2003 aa)
CALCOCO2Calcium-binding and coiled-coil domain-containing protein 2. (411 aa)
BLMBloom syndrome protein. (1383 aa)
TP53INP1Tumor protein p53-inducible nuclear protein 1 isoform X1. (238 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
ENSEEUP00000002216annotation not available (543 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (943 aa)
PARK7Protein deglycase DJ-1. (106 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (623 aa)
CHD3chromodomain-helicase-DNA-binding protein 3 isoform X4. (1962 aa)
ENSEEUP00000013950annotation not available (889 aa)
PIAS1E3 SUMO-protein ligase PIAS1. (397 aa)
HIPK3Homeodomain-interacting protein kinase 3 isoform X1. (1211 aa)
IKBKEInhibitor of nuclear factor kappa-B kinase subunit epsilon isoform X1. (477 aa)
TRIM16Tripartite motif-containing protein 16. (348 aa)
THAP1THAP domain-containing protein 1. (213 aa)
ENSEEUP00000003840annotation not available (191 aa)
TRIM8Probable E3 ubiquitin-protein ligase TRIM8. (553 aa)
SQSTM1Sequestosome 1. (373 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
CDK9Cyclin-dependent kinase 9; Belongs to the protein kinase superfamily. (419 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (595 aa)
KLHL20Kelch-like protein 20. (609 aa)
PIAS2E3 SUMO-protein ligase PIAS2 isoform X1. (613 aa)
ENSEEUP00000006339annotation not available (602 aa)
TOPBP1DNA topoisomerase 2-binding protein 1 isoform X1. (1452 aa)
RPAINRPA-interacting protein. (163 aa)
TP53INP2Tumor protein p53-inducible nuclear protein 2. (222 aa)
ENSEEUP00000007055annotation not available (2488 aa)
N4BP1NEDD4 binding protein 1. (930 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa)
ENSEEUP00000007762annotation not available (580 aa)
PPARGC1APeroxisome proliferator-activated receptor gamma coactivator 1-alpha isoform X3. (780 aa)
ZBTB16Zinc finger and BTB domain-containing protein 16. (673 aa)
HIPK1Homeodomain-interacting protein kinase 1 isoform X1. (915 aa)
WDFY3WD repeat and FYVE domain-containing protein 3 isoform X1. (3513 aa)
CASP8AP2CASP8-associated protein 2. (1902 aa)
ENSEEUP00000009429annotation not available (367 aa)
RNF111E3 ubiquitin-protein ligase Arkadia isoform X3. (869 aa)
SATB1DNA-binding protein SATB. (717 aa)
ENSEEUP00000009680annotation not available (616 aa)
TDP2tyrosyl-DNA phosphodiesterase 2. (356 aa)
RNF4E3 ubiquitin-protein ligase RNF4. (120 aa)
TOPORSE3 ubiquitin-protein ligase Topors isoform X1. (1032 aa)
ZMYM2Zinc finger MYM-type protein 2. (1378 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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