(55 nodes) Protein N-terminus binding network (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RASSF1	Ras association domain-containing protein 1 isoform X2. (188 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
	LRP8	Low-density lipoprotein receptor-related protein 8 isoform X2. (893 aa)
	CHMP6	Charged multivesicular body protein 6. (116 aa)
	PDCD10	Programmed cell death protein 10. (185 aa)
	HYPK	Huntingtin-interacting protein K. (162 aa)
	ENSEEUP00000013705	annotation not available (267 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (114 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
	SRRM2	Serine/arginine repetitive matrix protein 2 isoform X1. (2615 aa)
	EIF3E	Eukaryotic translation initiation factor 3 subunit E; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (284 aa)
	PEX5	Peroxisomal biogenesis factor 5 isoform X1. (562 aa)
	PARP1	Poly [ADP-ribose] polymerase. (1016 aa)
	ENSEEUP00000011189	annotation not available (1002 aa)
	EXOC2	Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (924 aa)
	ENSEEUP00000011122	annotation not available (2505 aa)
	ACOX1	acyl-CoA oxidase 1. (660 aa)
	THAP7	THAP domain-containing protein 7. (313 aa)
	PEX14	Peroxisomal membrane protein PEX14. (365 aa)
	ALG2	Alpha-1,3/1,6-mannosyltransferase ALG2. (415 aa)
	LOC103116283	General transcription factor IIH subunit 3-like isoform X2. (217 aa)
	ERCC2	TFIIH basal transcription factor complex helicase XPD subunit. (729 aa)
	STX5	Syntaxin-5 isoform X2; Belongs to the syntaxin family. (356 aa)
	CFAP36	Cilia- and flagella-associated protein 36. (204 aa)
	EXOC5	Exocyst complex component 5. (708 aa)
	DCTN4	Dynactin subunit 4 isoform X2. (460 aa)
	ENSEEUP00000008715	annotation not available (911 aa)
	GTF2H3	General transcription factor IIH subunit 3. (304 aa)
	ERCC6	DNA excision repair protein ERCC-6. (1468 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
	ERCC4	DNA repair endonuclease XPF. (918 aa)
	CSNK2A1	Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily. (395 aa)
	EXOC4	Exocyst complex component 4-like. (973 aa)
	SNF8	Vacuolar-sorting protein SNF8. (258 aa)
	MORF4L2	Mortality factor 4-like protein 2. (289 aa)
	ENSEEUP00000004944	annotation not available (389 aa)
	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (411 aa)
	TSC1	Hamartin isoform X2. (1109 aa)
	VWF	Von Willebrand factor. (2805 aa)
	HAX1	HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (202 aa)
	HESX1	Homeobox expressed in ES cells 1. (119 aa)
	MECP2	Methyl-CpG-binding protein 2; Chromosomal protein that binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. It is not influenced by sequences flanking the methyl-CpGs. Binds both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, with a preference for 5-methylcytosine (5mC). (466 aa)
	ENSEEUP00000002659	annotation not available (231 aa)
	SYNGR1	Synaptogyrin. (200 aa)
	ENSEEUP00000001573	annotation not available (291 aa)
	NCOA3	Nuclear receptor coactivator. (1400 aa)
	NIPBL	Nipped-B protein. (2794 aa)
	ENSEEUP00000001173	annotation not available (911 aa)
	TARBP2	RISC-loading complex subunit TARBP2; Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from [...] (313 aa)
	MNAT1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (269 aa)
	ERCC3	TFIIH basal transcription factor complex helicase XPB subunit isoform X1. (733 aa)
	ALOX5AP	Arachidonate 5-lipoxygenase-activating protein. (107 aa)
	CSNK2A2	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily. (315 aa)
	ENSEEUP00000000724	annotation not available (342 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (521 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACOX1	PEX14	ENSEEUP00000010847	ENSEEUP00000010184	acyl-CoA oxidase 1.	Peroxisomal membrane protein PEX14.	0.886
ACOX1	PEX5	ENSEEUP00000010847	ENSEEUP00000012429	acyl-CoA oxidase 1.	Peroxisomal biogenesis factor 5 isoform X1.	0.887
ALG2	ENSEEUP00000004944	ENSEEUP00000009943	ENSEEUP00000004944	Alpha-1,3/1,6-mannosyltransferase ALG2.	annotation not available	0.604
ALG2	ENSEEUP00000011189	ENSEEUP00000009943	ENSEEUP00000011189	Alpha-1,3/1,6-mannosyltransferase ALG2.	annotation not available	0.604
ALG2	ERCC4	ENSEEUP00000009943	ENSEEUP00000007144	Alpha-1,3/1,6-mannosyltransferase ALG2.	DNA repair endonuclease XPF.	0.593
ATM	ENSEEUP00000002659	ENSEEUP00000007164	ENSEEUP00000002659	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.433
ATM	ENSEEUP00000004944	ENSEEUP00000007164	ENSEEUP00000004944	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.755
ATM	ENSEEUP00000011189	ENSEEUP00000007164	ENSEEUP00000011189	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.755
ATM	ERCC2	ENSEEUP00000007164	ENSEEUP00000009661	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TFIIH basal transcription factor complex helicase XPD subunit.	0.773
ATM	ERCC3	ENSEEUP00000007164	ENSEEUP00000000948	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	TFIIH basal transcription factor complex helicase XPB subunit isoform X1.	0.536
ATM	ERCC4	ENSEEUP00000007164	ENSEEUP00000007144	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA repair endonuclease XPF.	0.651
ATM	NBN	ENSEEUP00000007164	ENSEEUP00000014581	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.993
ATM	PARP1	ENSEEUP00000007164	ENSEEUP00000011219	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Poly [ADP-ribose] polymerase.	0.684
ATM	PEX5	ENSEEUP00000007164	ENSEEUP00000012429	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Peroxisomal biogenesis factor 5 isoform X1.	0.951
ATM	TP53	ENSEEUP00000007164	ENSEEUP00000013295	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.996
CHMP6	SNF8	ENSEEUP00000014203	ENSEEUP00000005485	Charged multivesicular body protein 6.	Vacuolar-sorting protein SNF8.	0.984
CSNK2A1	CSNK2A2	ENSEEUP00000006407	ENSEEUP00000000830	Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily.	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	0.932
CSNK2A1	TP53	ENSEEUP00000006407	ENSEEUP00000013295	Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.795
CSNK2A1	TSC1	ENSEEUP00000006407	ENSEEUP00000003722	Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily.	Hamartin isoform X2.	0.446
CSNK2A2	CSNK2A1	ENSEEUP00000000830	ENSEEUP00000006407	Casein kinase II subunit alpha; Belongs to the protein kinase superfamily.	Casein kinase II subunit alpha isoform X1; Belongs to the protein kinase superfamily.	0.932