(51 nodes) Oogenesis network (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSEEUP00000007883	annotation not available (542 aa)
	BRCA2	Breast cancer type 2 susceptibility protein. (3345 aa)
	NANOS3	Nanos homolog 3; Belongs to the nanos family. (168 aa)
	NANOS2	Nanos homolog 2; Belongs to the nanos family. (138 aa)
	TDRD1	Tudor domain-containing protein 1. (1190 aa)
	INHBB	Inhibin beta B chain. (257 aa)
	ENSEEUP00000009564	annotation not available (2098 aa)
	EDNRA	Endothelin receptor type A. (428 aa)
	REC8	Meiotic recombination protein REC8 homolog. (556 aa)
	STRA8	Stimulated by retinoic acid gene 8 protein homolog. (326 aa)
	GDF9	Growth/differentiation factor 9. (451 aa)
	YTHDF2	LOW QUALITY PROTEIN: YTH domain-containing family protein 2. (579 aa)
	SPO11	Meiotic recombination protein SPO11. (406 aa)
	CDC25B	M-phase inducer phosphatase 2 isoform X1. (601 aa)
	ERCC1	DNA excision repair protein ERCC-1 isoform X2. (232 aa)
	ZP3	Zona pellucida sperm-binding protein 3. (225 aa)
	EHMT2	Histone-lysine N-methyltransferase EHMT2 isoform X1. (982 aa)
	TDRD15	Tudor domain-containing protein 15. (769 aa)
	H3-3A	H3 histone, family 3A. (136 aa)
	PLD6	Mitochondrial cardiolipin hydrolase. (248 aa)
	FOXO3	Forkhead box protein O3. (469 aa)
	DMC1	Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (323 aa)
	C14orf39	Protein SIX6OS1. (574 aa)
	EDN1	Endothelin-1. (202 aa)
	LGR5	Leucine rich repeat containing G protein-coupled receptor 5. (905 aa)
	YTHDC1	YTH domain-containing protein 1 isoform X2. (728 aa)
	H3F3A-2	H3 histone, family 3A. (136 aa)
	TDRKH	Tudor and KH domain containing. (546 aa)
	MTHFSD	Methenyltetrahydrofolate synthase domain-containing protein. (374 aa)
	DDX20	Probable ATP-dependent RNA helicase DDX20. (483 aa)
	TRIP13	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family. (278 aa)
	GPR149	Probable G-protein coupled receptor 149. (733 aa)
	WASHC5	WASH complex subunit strumpellin. (1159 aa)
	SOHLH1	Spermatogenesis- and oogenesis-specific basic helix-loop-helix-containing protein 1. (237 aa)
	PTN	Pleiotrophin isoform X1. (168 aa)
	BMPR1B	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (453 aa)
	H3F3A	Histone H3; Belongs to the histone H3 family. (136 aa)
	TDRD5	Tudor domain-containing protein 5. (956 aa)
	CCDC36	Coiled-coil domain-containing protein 36. (552 aa)
	ENSEEUP00000003367	annotation not available (344 aa)
	MARF1	Meiosis arrest female protein 1 isoform X1. (1719 aa)
	ZNF830	Zinc finger protein 830. (361 aa)
	PAQR5	Membrane progestin receptor gamma. (233 aa)
	CCDC155	Coiled-coil domain containing 155. (537 aa)
	SRC	Tyrosine-protein kinase. (539 aa)
	PIWIL2	Piwi-like protein 2; Belongs to the argonaute family. (882 aa)
	ENSEEUP00000005780	annotation not available (124 aa)
	HORMAD1	HORMA domain-containing protein 1. (391 aa)
	PTX3	Pentraxin-related protein PTX3. (223 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
	PDE3A	Phosphodiesterase. (1110 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATM	BMPR1B	ENSEEUP00000007164	ENSEEUP00000002026	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.452
ATM	BRCA2	ENSEEUP00000007164	ENSEEUP00000008968	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Breast cancer type 2 susceptibility protein.	0.954
ATM	DMC1	ENSEEUP00000007164	ENSEEUP00000013011	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family.	0.813
ATM	EHMT2	ENSEEUP00000007164	ENSEEUP00000011871	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone-lysine N-methyltransferase EHMT2 isoform X1.	0.446
ATM	ENSEEUP00000005780	ENSEEUP00000007164	ENSEEUP00000005780	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.654
ATM	ERCC1	ENSEEUP00000007164	ENSEEUP00000011651	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA excision repair protein ERCC-1 isoform X2.	0.694
ATM	H3-3A	ENSEEUP00000007164	ENSEEUP00000012558	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	H3 histone, family 3A.	0.654
ATM	H3F3A	ENSEEUP00000007164	ENSEEUP00000002037	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Histone H3; Belongs to the histone H3 family.	0.654
ATM	H3F3A-2	ENSEEUP00000007164	ENSEEUP00000014315	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	H3 histone, family 3A.	0.654
ATM	HORMAD1	ENSEEUP00000007164	ENSEEUP00000006419	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	HORMA domain-containing protein 1.	0.469
ATM	SPO11	ENSEEUP00000007164	ENSEEUP00000010643	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Meiotic recombination protein SPO11.	0.831
ATM	SRC	ENSEEUP00000007164	ENSEEUP00000005236	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.569
ATM	TRIP13	ENSEEUP00000007164	ENSEEUP00000000479	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family.	0.487
BMPR1B	ATM	ENSEEUP00000002026	ENSEEUP00000007164	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.452
BMPR1B	GDF9	ENSEEUP00000002026	ENSEEUP00000010126	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Growth/differentiation factor 9.	0.978
BMPR1B	INHBB	ENSEEUP00000002026	ENSEEUP00000009555	Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Inhibin beta B chain.	0.939
BRCA2	ATM	ENSEEUP00000008968	ENSEEUP00000007164	Breast cancer type 2 susceptibility protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.954
BRCA2	DMC1	ENSEEUP00000008968	ENSEEUP00000013011	Breast cancer type 2 susceptibility protein.	Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family.	0.949
BRCA2	ERCC1	ENSEEUP00000008968	ENSEEUP00000011651	Breast cancer type 2 susceptibility protein.	DNA excision repair protein ERCC-1 isoform X2.	0.528
BRCA2	SPO11	ENSEEUP00000008968	ENSEEUP00000010643	Breast cancer type 2 susceptibility protein.	Meiotic recombination protein SPO11.	0.618