(78 nodes) Regulation of B cell activation network (Erinaceus europaeus)

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	ENSEEUP00000000513	annotation not available (566 aa)
	PARP3	Poly [ADP-ribose] polymerase. (536 aa)
	ENSEEUP00000000794	annotation not available (256 aa)
	ENSEEUP00000001140	annotation not available (787 aa)
	TBC1D10C	Carabin. (400 aa)
	SLAMF8	SLAM family member 8. (151 aa)
	AHR	Aryl hydrocarbon receptor. (822 aa)
	ENSEEUP00000002447	annotation not available (1279 aa)
	HMCES	5-hydroxymethylcytosine binding, ES cell specific. (355 aa)
	PTPN6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (448 aa)
	BAD	Bcl2-associated agonist of cell death. (165 aa)
	MEF2C	Myocyte-specific enhancer factor 2C isoform X1. (435 aa)
	LOC103126088	Sialic acid-binding Ig-like lectin 16. (535 aa)
	STAT5A	Signal transducer and activator of transcription. (750 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (149 aa)
	ENSEEUP00000003620	annotation not available (206 aa)
	TNFAIP3	Tumor necrosis factor alpha-induced protein 3. (627 aa)
	LOC103118983	ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1. (201 aa)
	ENSEEUP00000003992	annotation not available (453 aa)
	FOXJ1	Forkhead box protein J1. (418 aa)
	ENSEEUP00000004492	annotation not available (120 aa)
	VAV3	Vav guanine nucleotide exchange factor 3. (845 aa)
	ENSEEUP00000004725	annotation not available (118 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	SFRP1	Secreted frizzled-related protein 1. (207 aa)
	SH3KBP1	SH3 domain-containing kinase-binding protein 1 isoform X2. (627 aa)
	GPR183	G-protein coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	ENSEEUP00000005376	annotation not available (847 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (216 aa)
	ENSEEUP00000006572	annotation not available (1974 aa)
	PELI1	Pellino E3 ubiquitin protein ligase 1. (417 aa)
	TNFRSF13C	Tumor necrosis factor receptor superfamily member 13C. (133 aa)
	CD74	HLA class II histocompatibility antigen gamma chain isoform X1. (286 aa)
	ATM	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
	THEMIS2	Protein THEMIS2. (570 aa)
	ENSEEUP00000007488	annotation not available (633 aa)
	SUPT6H	Transcription elongation factor spt6; Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). Belongs to the SPT6 family. (1702 aa)
	CD19	B-lymphocyte antigen CD19. (360 aa)
	ADA	Adenosine deaminase. (362 aa)
	LOC103116464	Polycomb complex protein BMI-1. (326 aa)
	TBX21	T-box transcription factor TBX21. (367 aa)
	BLK	Tyrosine-protein kinase. (500 aa)
	NFATC2	Nuclear factor of activated T-cells, cytoplasmic 2. (918 aa)
	SYK	Spleen associated tyrosine kinase. (607 aa)
	XBP1	LOW QUALITY PROTEIN: X-box-binding protein 1. (271 aa)
	BCL6	B-cell lymphoma 6 protein. (708 aa)
	ENSEEUP00000009144	annotation not available (459 aa)
	NDFIP1	NEDD4 family-interacting protein 1. (175 aa)
	SASH3	SAM and SH3 domain-containing protein 3. (380 aa)
	ENSEEUP00000010545	annotation not available (372 aa)
	AKIRIN2	Akirin 2. (204 aa)
	CDKN1A	Cyclin-dependent kinase inhibitor 1. (159 aa)
	ENSEEUP00000011153	annotation not available (638 aa)
	CD28	T-cell-specific surface glycoprotein CD28. (233 aa)
	ENSEEUP00000011377	annotation not available (827 aa)
	MZB1	Marginal zone B- and B1-cell-specific protein. (113 aa)
	ATAD5	ATPase family AAA domain containing 5. (1813 aa)
	RIF1	Replication timing regulatory factor 1. (2367 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X3. (365 aa)
	KMT5B	Lysine methyltransferase 5B. (876 aa)
	TYROBP	TYRO protein tyrosine kinase-binding protein isoform X1. (110 aa)
	IL7	Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (167 aa)
	MMP14	Matrix metalloproteinase-14. (583 aa)
	TLR9	Toll-like receptor 9. (1053 aa)
	EXOSC3	Exosome complex component RRP40. (202 aa)
	IL10	Interleukin-10. (102 aa)
	RC3H1	Roquin-1 isoform X1. (1078 aa)
	ENSEEUP00000013637	annotation not available (119 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1365 aa)
	IL27RA	Interleukin-27 receptor subunit alpha. (424 aa)
	TNFRSF21	Tumor necrosis factor receptor superfamily member 21. (547 aa)
	CD22	B-cell receptor CD22. (840 aa)
	ENSEEUP00000014125	annotation not available (761 aa)
	MORN5	MORN repeat-containing protein 5. (162 aa)
	BTK	Tyrosine-protein kinase. (659 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
	ENSEEUP00000014382	annotation not available (1012 aa)
	NCKAP1L	Nck-associated protein 1-like isoform X1. (1128 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADA	IL2	ENSEEUP00000007810	ENSEEUP00000003509	Adenosine deaminase.	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family.	0.740
ATAD5	ATM	ENSEEUP00000011589	ENSEEUP00000007164	ATPase family AAA domain containing 5.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.683
ATAD5	ENSEEUP00000000513	ENSEEUP00000011589	ENSEEUP00000000513	ATPase family AAA domain containing 5.	annotation not available	0.484
ATAD5	MAD2L2	ENSEEUP00000011589	ENSEEUP00000005386	ATPase family AAA domain containing 5.	Mitotic spindle assembly checkpoint protein MAD2B.	0.652
ATAD5	MSH2	ENSEEUP00000011589	ENSEEUP00000014300	ATPase family AAA domain containing 5.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.445
ATAD5	PARP3	ENSEEUP00000011589	ENSEEUP00000000614	ATPase family AAA domain containing 5.	Poly [ADP-ribose] polymerase.	0.429
ATM	ATAD5	ENSEEUP00000007164	ENSEEUP00000011589	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	ATPase family AAA domain containing 5.	0.683
ATM	BLK	ENSEEUP00000007164	ENSEEUP00000008898	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.466
ATM	BTK	ENSEEUP00000007164	ENSEEUP00000014292	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.517
ATM	CDKN1A	ENSEEUP00000007164	ENSEEUP00000011004	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Cyclin-dependent kinase inhibitor 1.	0.487
ATM	ENSEEUP00000000513	ENSEEUP00000007164	ENSEEUP00000000513	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.945
ATM	ENSEEUP00000006572	ENSEEUP00000007164	ENSEEUP00000006572	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.977
ATM	ENSEEUP00000009144	ENSEEUP00000007164	ENSEEUP00000009144	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	annotation not available	0.450
ATM	LOC103116464	ENSEEUP00000007164	ENSEEUP00000007866	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Polycomb complex protein BMI-1.	0.555
ATM	MSH2	ENSEEUP00000007164	ENSEEUP00000014300	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.747
ATM	NSD2	ENSEEUP00000007164	ENSEEUP00000013641	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Nuclear receptor binding SET domain protein 2.	0.695
ATM	RIF1	ENSEEUP00000007164	ENSEEUP00000012060	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Replication timing regulatory factor 1.	0.907
ATM	SYK	ENSEEUP00000007164	ENSEEUP00000008942	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Spleen associated tyrosine kinase.	0.467
BCL6	CD19	ENSEEUP00000000302	ENSEEUP00000007704	B-cell lymphoma 6 protein.	B-lymphocyte antigen CD19.	0.712
BCL6	CD74	ENSEEUP00000000302	ENSEEUP00000007028	B-cell lymphoma 6 protein.	HLA class II histocompatibility antigen gamma chain isoform X1.	0.492