STRINGSTRING
OVOL1 OVOL1 ENSEEUP00000000021 ENSEEUP00000000021 SLC26A8 SLC26A8 TUBGCP5 TUBGCP5 CCNE1 CCNE1 TRIP13 TRIP13 NUF2 NUF2 RAD50 RAD50 ESPL1 ESPL1 TEX15 TEX15 WASHC5 WASHC5 CYP26B1 CYP26B1 RAD51D RAD51D SYCP1 SYCP1 NSUN2 NSUN2 FBXO5 FBXO5 RAD51C RAD51C RBBP8 RBBP8 NCAPH2 NCAPH2 CCNE2 CCNE2 RPA1 RPA1 SYCP2L SYCP2L AURKA AURKA ENSEEUP00000002581 ENSEEUP00000002581 ENSEEUP00000002614 ENSEEUP00000002614 C1orf146 C1orf146 ENSEEUP00000002890 ENSEEUP00000002890 BOLL BOLL TEX12 TEX12 CCDC36 CCDC36 ING2 ING2 MARF1 MARF1 SPIRE2 SPIRE2 ZCWPW1 ZCWPW1 MEI1 MEI1 STK35 STK35 LOC103126807 LOC103126807 ENSEEUP00000004369 ENSEEUP00000004369 LOC103109665 LOC103109665 SGO1 SGO1 ENSEEUP00000004704 ENSEEUP00000004704 PRR19 PRR19 ENSEEUP00000004759 ENSEEUP00000004759 NCAPD3 NCAPD3 FANCM FANCM CCDC155 CCDC155 INCENP INCENP SGO2 SGO2 TOP2B TOP2B ENSEEUP00000005932 ENSEEUP00000005932 MND1 MND1 TUBGCP4 TUBGCP4 PDIK1L PDIK1L HORMAD1 HORMAD1 TUBGCP6 TUBGCP6 KIF18A KIF18A ENSEEUP00000006794 ENSEEUP00000006794 SEPTIN1 SEPTIN1 ENSEEUP00000007055 ENSEEUP00000007055 ENSEEUP00000007083 ENSEEUP00000007083 ERCC4 ERCC4 ATM ATM BAG6 BAG6 RAD54B RAD54B SYCP3 SYCP3 RAD54L RAD54L MIS18BP1 MIS18BP1 ENSEEUP00000007481 ENSEEUP00000007481 RAD1 RAD1 MRE11 MRE11 TDRD12 TDRD12 ENSEEUP00000007762 ENSEEUP00000007762 ROCK1 ROCK1 UBR2 UBR2 TERF1 TERF1 ENSEEUP00000008303 ENSEEUP00000008303 ENSEEUP00000008346 ENSEEUP00000008346 M1AP M1AP FIGNL1 FIGNL1 ENSEEUP00000008705 ENSEEUP00000008705 MNS1 MNS1 BRCA2 BRCA2 CNTD1 CNTD1 SMC3 SMC3 BCL2L11 BCL2L11 KLHDC3 KLHDC3 ENSEEUP00000009565 ENSEEUP00000009565 BUB1 BUB1 EME1 EME1 MSH4 MSH4 HUS1 HUS1 EDNRA EDNRA SPATA22 SPATA22 REC8 REC8 ENSEEUP00000009969 ENSEEUP00000009969 RMI1 RMI1 STRA8 STRA8 ENSEEUP00000010191 ENSEEUP00000010191 SYCP2 SYCP2 FOXJ2 FOXJ2 ENSEEUP00000010340 ENSEEUP00000010340 SPO11 SPO11 SMC1B SMC1B DDX4 DDX4 CDC25B CDC25B SUN1 SUN1 ENSEEUP00000011645 ENSEEUP00000011645 ERCC1 ERCC1 EHMT2 EHMT2 PTTG1 PTTG1 SMC4 SMC4 SLC4A1AP SLC4A1AP BUB1B BUB1B TTK TTK PLD6 PLD6 MLH3 MLH3 MAEL MAEL CDK2 CDK2 FANCD2 FANCD2 DMC1 DMC1 PKMYT1 PKMYT1 TEX11 TEX11 ENSEEUP00000013306 ENSEEUP00000013306 MEIOB MEIOB C14orf39 C14orf39 SPIRE1 SPIRE1 ACTR3 ACTR3 ASZ1 ASZ1 EDN1 EDN1 SYCE1 SYCE1 SLX4 SLX4 MUS81 MUS81 CCDC79 CCDC79 RBM7 RBM7 ENSEEUP00000014511 ENSEEUP00000014511 TDRKH TDRKH NBN NBN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OVOL1Putative transcription factor Ovo-like 1. (160 aa)
ENSEEUP00000000021annotation not available (607 aa)
SLC26A8Solute carrier family 26 member 8. (956 aa)
TUBGCP5Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (1016 aa)
CCNE1LOW QUALITY PROTEIN: G1/S-specific cyclin-E1; Belongs to the cyclin family. (410 aa)
TRIP13Pachytene checkpoint protein 2 homolog; Belongs to the AAA ATPase family. (278 aa)
NUF2Kinetochore protein Nuf2. (420 aa)
RAD50DNA repair protein RAD50 isoform X1. (1311 aa)
ESPL1Separin. (2102 aa)
TEX15Testis-expressed sequence 15 protein. (2748 aa)
WASHC5WASH complex subunit strumpellin. (1159 aa)
CYP26B1Cytochrome P450 26B1 isoform X1; Belongs to the cytochrome P450 family. (369 aa)
RAD51DDNA repair protein RAD51 homolog 4 isoform X1. (327 aa)
SYCP1Synaptonemal complex protein 1. (867 aa)
NSUN2tRNA (Cytosine(34)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (477 aa)
FBXO5F-box only protein 5. (406 aa)
RAD51CDNA repair protein RAD51 homolog 3. (377 aa)
RBBP8DNA endonuclease RBBP8. (903 aa)
NCAPH2Condensin-2 complex subunit H2 isoform X2. (595 aa)
CCNE2G1/S-specific cyclin-E2 isoform X2; Belongs to the cyclin family. (403 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
SYCP2LSynaptonemal complex protein 2-like. (752 aa)
AURKAAurora kinase A isoform X1; Belongs to the protein kinase superfamily. (404 aa)
ENSEEUP00000002581annotation not available (812 aa)
ENSEEUP00000002614annotation not available (221 aa)
C1orf146Uncharacterized protein C1orf146 homolog. (161 aa)
ENSEEUP00000002890annotation not available (756 aa)
BOLLBoule homolog, RNA binding protein. (337 aa)
TEX12Testis-expressed sequence 12 protein. (123 aa)
CCDC36Coiled-coil domain-containing protein 36. (552 aa)
ING2Inhibitor of growth protein. (222 aa)
MARF1Meiosis arrest female protein 1 isoform X1. (1719 aa)
SPIRE2Protein spire homolog 2 isoform X2. (721 aa)
ZCWPW1Zinc finger CW-type PWWP domain protein 1. (501 aa)
MEI1Meiotic double-stranded break formation protein 1. (1219 aa)
STK35Serine/threonine-protein kinase 35 isoform X1. (402 aa)
LOC103126807Uncharacterized protein C9orf84 homolog. (1497 aa)
ENSEEUP00000004369annotation not available (1233 aa)
LOC103109665Uncharacterized protein C11orf80 homolog. (329 aa)
SGO1Shugoshin-like 1. (522 aa)
ENSEEUP00000004704annotation not available (1610 aa)
PRR19Proline-rich protein 19. (359 aa)
ENSEEUP00000004759annotation not available (683 aa)
NCAPD3Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1495 aa)
FANCMFanconi anemia group M protein. (1962 aa)
CCDC155Coiled-coil domain containing 155. (537 aa)
INCENPInner centromere protein isoform X2. (869 aa)
SGO2LOW QUALITY PROTEIN: shugoshin-like 2. (1162 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1601 aa)
ENSEEUP00000005932annotation not available (217 aa)
MND1Meiotic nuclear division protein 1 homolog. (204 aa)
TUBGCP4Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (667 aa)
PDIK1LSerine/threonine-protein kinase PDIK1L; Belongs to the protein kinase superfamily. (341 aa)
HORMAD1HORMA domain-containing protein 1. (391 aa)
TUBGCP6Gamma-tubulin complex component; Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome; Belongs to the TUBGCP family. (1806 aa)
KIF18AKinesin family member 18A. (896 aa)
ENSEEUP00000006794annotation not available (388 aa)
SEPTIN1Septin-1; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (367 aa)
ENSEEUP00000007055annotation not available (2488 aa)
ENSEEUP00000007083annotation not available (1141 aa)
ERCC4DNA repair endonuclease XPF. (918 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
BAG6Large proline-rich protein BAG6 isoform X1. (1161 aa)
RAD54BDNA repair and recombination protein RAD54B. (904 aa)
SYCP3Synaptonemal complex protein 3. (191 aa)
RAD54LDNA repair and recombination protein RAD54-like. (747 aa)
MIS18BP1Mis18-binding protein 1. (869 aa)
ENSEEUP00000007481annotation not available (924 aa)
RAD1Cell cycle checkpoint protein RAD1. (281 aa)
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa)
TDRD12Putative ATP-dependent RNA helicase TDRD12. (1101 aa)
ENSEEUP00000007762annotation not available (580 aa)
ROCK1Rho-associated protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1295 aa)
UBR2Ubiquitin protein ligase E3 component n-recognin 2. (1752 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa)
ENSEEUP00000008303annotation not available (304 aa)
ENSEEUP00000008346annotation not available (218 aa)
M1APMeiosis 1 arrest protein. (447 aa)
FIGNL1Fidgetin-like protein 1; Belongs to the AAA ATPase family. (677 aa)
ENSEEUP00000008705annotation not available (165 aa)
MNS1Meiosis-specific nuclear structural protein 1. (495 aa)
BRCA2Breast cancer type 2 susceptibility protein. (3345 aa)
CNTD1Cyclin N-terminal domain-containing protein 1. (329 aa)
SMC3Structural maintenance of chromosomes protein 3. (1219 aa)
BCL2L11Bcl-2-like protein 11; Induces apoptosis and anoikis. Belongs to the Bcl-2 family. (197 aa)
KLHDC3Kelch domain-containing protein 3 isoform X1. (271 aa)
ENSEEUP00000009565annotation not available (605 aa)
BUB1Mitotic checkpoint serine/threonine-protein kinase BUB1. (1068 aa)
EME1Crossover junction endonuclease EME1 isoform X1. (563 aa)
MSH4mutS protein homolog 4. (933 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (279 aa)
EDNRAEndothelin receptor type A. (428 aa)
SPATA22Spermatogenesis-associated protein 22 isoform X1. (363 aa)
REC8Meiotic recombination protein REC8 homolog. (556 aa)
ENSEEUP00000009969annotation not available (651 aa)
RMI1recQ-mediated genome instability protein 1. (608 aa)
STRA8Stimulated by retinoic acid gene 8 protein homolog. (326 aa)
ENSEEUP00000010191annotation not available (822 aa)
SYCP2Synaptonemal complex protein 2. (1433 aa)
FOXJ2Forkhead box protein J2. (319 aa)
ENSEEUP00000010340annotation not available (1398 aa)
SPO11Meiotic recombination protein SPO11. (406 aa)
SMC1BStructural maintenance of chromosomes protein 1B. (1204 aa)
DDX4Probable ATP-dependent RNA helicase DDX4 isoform X2; Belongs to the DEAD box helicase family. (724 aa)
CDC25BM-phase inducer phosphatase 2 isoform X1. (601 aa)
SUN1Sad1 and UNC84 domain containing 1. (813 aa)
ENSEEUP00000011645annotation not available (1440 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X2. (232 aa)
EHMT2Histone-lysine N-methyltransferase EHMT2 isoform X1. (982 aa)
PTTG1Securin isoform X1. (201 aa)
SMC4Structural maintenance of chromosomes protein. (1274 aa)
SLC4A1APSolute carrier family 4 member 1 adaptor protein. (793 aa)
BUB1BMitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1043 aa)
TTKDual specificity protein kinase TTK. (772 aa)
PLD6Mitochondrial cardiolipin hydrolase. (248 aa)
MLH3DNA mismatch repair protein Mlh3 isoform X1. (1403 aa)
MAELProtein maelstrom homolog isoform X1. (427 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
FANCD2Fanconi anemia group D2 protein. (1462 aa)
DMC1Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (323 aa)
PKMYT1Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase isoform X1; Belongs to the protein kinase superfamily. (493 aa)
TEX11Testis-expressed sequence 11 protein. (823 aa)
ENSEEUP00000013306annotation not available (670 aa)
MEIOBMeiosis-specific with OB domain-containing protein. (214 aa)
C14orf39Protein SIX6OS1. (574 aa)
SPIRE1Protein spire homolog 1 isoform X3. (582 aa)
ACTR3Actin-related protein 3 isoform X2; Belongs to the actin family. (343 aa)
ASZ1Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 isoform X1. (425 aa)
EDN1Endothelin-1. (202 aa)
SYCE1Synaptonemal complex central element protein 1. (306 aa)
SLX4Structure-specific endonuclease subunit SLX4. (1553 aa)
MUS81Crossover junction endonuclease MUS81 isoform X3. (464 aa)
CCDC79Telomere repeats-binding bouquet formation protein 1. (493 aa)
RBM7RNA-binding protein 7 isoform X3. (261 aa)
ENSEEUP00000014511annotation not available (150 aa)
TDRKHTudor and KH domain containing. (546 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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