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| | CHD8 | Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2299 aa) |
| | G3BP1 | Ras GTPase-activating protein-binding protein 1. (463 aa) |
| | MTERF1 | Transcription termination factor 1, mitochondrial. (391 aa) |
| | CHD7 | chromodomain-helicase-DNA-binding protein 7. (2994 aa) |
| | SLFNL1 | Schlafen-like protein 1. (387 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (279 aa) |
| | CHD9 | chromodomain-helicase-DNA-binding protein 9 isoform X1. (2785 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (536 aa) |
| | ENSEEUP00000013883 | annotation not available (218 aa) |
| | SMARCAD1 | annotation not available (1004 aa) |
| | CHD3 | chromodomain-helicase-DNA-binding protein 3 isoform X4. (1962 aa) |
| | ERCC6L | DNA excision repair protein ERCC-6-like. (1241 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | CHD6 | chromodomain-helicase-DNA-binding protein 6. (2712 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa) |
| | ENSEEUP00000007672 | annotation not available (902 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (829 aa) |
| | TOP1 | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (741 aa) |
| | ENSEEUP00000007055 | annotation not available (2488 aa) |
| | SUPV3L1 | ATP-dependent RNA helicase SUPV3L1, mitochondrial. (783 aa) |
| | MCM7 | Minichromosome maintenance complex component 7. (682 aa) |
| | ANXA1 | Annexin. (338 aa) |
| | ENSEEUP00000006794 | annotation not available (388 aa) |
| | ENSEEUP00000006577 | annotation not available (598 aa) |
| | NAV2 | Neuron navigator 2 isoform X1. (2467 aa) |
| | MCM8 | DNA helicase MCM8 isoform X1; Belongs to the MCM family. (822 aa) |
| | CHD1 | Chromodomain helicase DNA binding protein 1. (1710 aa) |
| | CDC45 | Cell division control protein 45 homolog. (481 aa) |
| | ENSEEUP00000005927 | annotation not available (647 aa) |
| | TOP2B | DNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1601 aa) |
| | FANCM | Fanconi anemia group M protein. (1962 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1276 aa) |
| | ENSEEUP00000004885 | annotation not available (315 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (625 aa) |
| | ENSEEUP00000004813 | annotation not available (1112 aa) |
| | ENSEEUP00000004704 | annotation not available (1610 aa) |
| | MCM3 | DNA helicase; Belongs to the MCM family. (788 aa) |
| | ENSEEUP00000004580 | annotation not available (624 aa) |
| | WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa) |
| | GINS4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | DHX9 | ATP-dependent RNA helicase A isoform X1. (1265 aa) |
| | ENSEEUP00000004366 | annotation not available (627 aa) |
| | MCMDC2 | MCM domain-containing protein 2 isoform X2. (590 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (436 aa) |
| | CHD1L | chromodomain-helicase-DNA-binding protein 1-like isoform X1. (873 aa) |
| | HELB | DNA helicase B. (1070 aa) |
| | HHEX | Hematopoietically-expressed homeobox protein HHEX. (148 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (820 aa) |
| | DDX3X | ATP-dependent RNA helicase DDX3X isoform X4; Belongs to the DEAD box helicase family. (647 aa) |
| | CHD5 | Chromodomain helicase DNA binding protein 5. (1924 aa) |
| | ENSEEUP00000002125 | annotation not available (198 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | CHD2 | chromodomain-helicase-DNA-binding protein 2. (1635 aa) |
| | ABL1 | Tyrosine-protein kinase. (925 aa) |
| | DDX1 | ATP-dependent RNA helicase DDX1. (730 aa) |
| | BLM | Bloom syndrome protein. (1383 aa) |
| | ENSEEUP00000001197 | annotation not available (599 aa) |
| | POLQ | DNA polymerase theta. (2561 aa) |
| | ERCC3 | TFIIH basal transcription factor complex helicase XPB subunit isoform X1. (733 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1311 aa) |
| | FBH1 | F-box DNA helicase 1 isoform X1. (977 aa) |
| | SUB1 | Activated RNA polymerase II transcriptional coactivator p15. (102 aa) |
| | TWNK | Twinkle protein, mitochondrial. (682 aa) |
| | RFC3 | Replication factor C subunit 3. (353 aa) |
| | ENSEEUP00000008566 | annotation not available (709 aa) |
| | DERPC | Chromosome transmission fidelity protein 8 homolog. (525 aa) |
| | ASCC3 | Activating signal cointegrator 1 complex subunit 3. (1933 aa) |
| | RECQL5 | ATP-dependent DNA helicase Q5. (979 aa) |
| | ENSEEUP00000009565 | annotation not available (605 aa) |
| | DHX36 | ATP-dependent RNA helicase DHX36 isoform X1. (1007 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | ERCC2 | TFIIH basal transcription factor complex helicase XPD subunit. (729 aa) |
| | SSBP1 | Single-stranded DNA-binding protein, mitochondrial. (147 aa) |
| | GTF2F2 | General transcription factor IIF subunit 2. (249 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (483 aa) |
| | ZRANB3 | DNA annealing helicase and endonuclease ZRANB3 isoform X1. (1000 aa) |
| | BRIP1 | Fanconi anemia group J protein. (1239 aa) |
| | ENSEEUP00000010821 | annotation not available (1785 aa) |
| | DDX11 | Probable ATP-dependent DNA helicase DDX11. (801 aa) |
| | WRNIP1 | ATPase WRNIP1 isoform X1. (533 aa) |
| | RUVBL1 | RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (338 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (943 aa) |
