Your Input: | |
| | SMCHD1 | Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1290 aa) |
| | OIP5 | Protein Mis18-beta. (228 aa) |
| | WDR82 | WD repeat domain 82. (304 aa) |
| | MTBP | Mdm2-binding protein. (903 aa) |
| | CLASP1 | CLIP-associating protein 1 isoform X6. (1499 aa) |
| | KDM1A | Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (872 aa) |
| | ENSEEUP00000006137 | annotation not available (383 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (188 aa) |
| | CHAMP1 | Chromosome alignment-maintaining phosphoprotein 1 isoform X2. (802 aa) |
| | CLASP2 | CLIP-associating protein 2 isoform X5. (1505 aa) |
| | TOX4 | TOX high mobility group box family member 4 isoform X1. (619 aa) |
| | ENSEEUP00000006554 | annotation not available (397 aa) |
| | ENSEEUP00000006572 | annotation not available (1974 aa) |
| | ENSEEUP00000006577 | annotation not available (598 aa) |
| | CBX3 | Chromobox 3. (183 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase. (272 aa) |
| | KIF18A | Kinesin family member 18A. (896 aa) |
| | NCAPG | Condensin complex subunit 3. (749 aa) |
| | CENPQ | Centromere protein Q. (262 aa) |
| | ZWILCH | Protein zwilch homolog. (553 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (451 aa) |
| | HELLS | Lymphoid-specific helicase isoform X1. (793 aa) |
| | ENSEEUP00000007055 | annotation not available (2488 aa) |
| | ERCC4 | DNA repair endonuclease XPF. (918 aa) |
| | CENPW | Centromere protein W isoform X1. (103 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa) |
| | DCTN1 | Dynactin subunit 1 isoform X1. (1279 aa) |
| | SYCP3 | Synaptonemal complex protein 3. (191 aa) |
| | MIS18BP1 | Mis18-binding protein 1. (869 aa) |
| | ENSEEUP00000007481 | annotation not available (924 aa) |
| | ENSEEUP00000007506 | annotation not available (493 aa) |
| | DCTN6 | Dynactin subunit 6. (159 aa) |
| | ENSEEUP00000007682 | annotation not available (309 aa) |
| | SKA3 | Spindle and kinetochore-associated protein 3. (413 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa) |
| | ENSEEUP00000007707 | annotation not available (128 aa) |
| | CDT1 | DNA replication factor Cdt1. (541 aa) |
| | SPC25 | Kinetochore protein Spc25. (226 aa) |
| | ENSEEUP00000007942 | annotation not available (1207 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa) |
| | PAFAH1B1 | Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa) |
| | ENSEEUP00000008137 | annotation not available (338 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa) |
| | CDCA8 | Borealin. (203 aa) |
| | XPO1 | Exportin-1. (1071 aa) |
| | ENSEEUP00000008705 | annotation not available (165 aa) |
| | ORC2 | Origin recognition complex subunit 2. (548 aa) |
| | MAD2L1 | Mitotic spindle assembly checkpoint protein MAD2A. (196 aa) |
| | ENSEEUP00000008832 | annotation not available (514 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3345 aa) |
| | POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1173 aa) |
| | SEPT2 | Septin-2; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (358 aa) |
| | SMC3 | Structural maintenance of chromosomes protein 3. (1219 aa) |
| | ZNF618 | Zinc finger protein 618 isoform X1. (951 aa) |
| | KAT2B | Lysine acetyltransferase 2B. (787 aa) |
| | NABP1 | SOSS complex subunit B2. (127 aa) |
| | ENSEEUP00000009527 | annotation not available (196 aa) |
| | DHX36 | ATP-dependent RNA helicase DHX36 isoform X1. (1007 aa) |
| | BUB1 | Mitotic checkpoint serine/threonine-protein kinase BUB1. (1068 aa) |
| | APC | Adenomatous polyposis coli protein isoform X1. (2846 aa) |
| | REC8 | Meiotic recombination protein REC8 homolog. (556 aa) |
| | ENSEEUP00000010059 | annotation not available (379 aa) |
| | CHMP3 | Charged multivesicular body protein 3 isoform X1. (221 aa) |
| | ENSEEUP00000010340 | annotation not available (1398 aa) |
| | ENSEEUP00000010530 | annotation not available (1251 aa) |
| | NDC80 | Kinetochore protein NDC80 homolog. (449 aa) |
| | NUP133 | LOW QUALITY PROTEIN: nuclear pore complex protein Nup133. (1010 aa) |
| | SPO11 | Meiotic recombination protein SPO11. (406 aa) |
| | DYNLT3 | Dynein light chain Tctex-type 3. (102 aa) |
| | ENSEEUP00000010729 | annotation not available (447 aa) |
| | NGDN | Neuroguidin. (237 aa) |
| | ENSEEUP00000010821 | annotation not available (1785 aa) |
| | WRNIP1 | ATPase WRNIP1 isoform X1. (533 aa) |
| | SMC1B | Structural maintenance of chromosomes protein 1B. (1204 aa) |
| | AHCTF1 | Protein ELYS. (2216 aa) |
| | ENSEEUP00000011153 | annotation not available (638 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (797 aa) |
| | ENSEEUP00000011251 | annotation not available (593 aa) |
| | ZBTB10 | Zinc finger and BTB domain-containing protein 10 isoform X2. (776 aa) |
| | CHMP2B | Charged multivesicular body protein 2b isoform X2. (213 aa) |
| | ZNF276 | Zinc finger protein 276 isoform X1. (406 aa) |
| | HJURP | Holliday junction recognition protein. (689 aa) |
| | DYNC1LI1 | Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (448 aa) |
| | LRWD1 | Leucine-rich repeat and WD repeat-containing protein 1. (643 aa) |
| | SUN2 | SUN domain-containing protein 2. (383 aa) |
| | ZNF330 | Zinc finger protein 330. (279 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1 isoform X2. (232 aa) |
| | ENSEEUP00000011699 | annotation not available (481 aa) |
| | HMBOX1 | Homeobox-containing protein 1 isoform X2. (420 aa) |
| | CKAP5 | Cytoskeleton-associated protein 5. (2012 aa) |
| | ENSEEUP00000011924 | annotation not available (560 aa) |
| | SMARCA5 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (993 aa) |
| | DCTN2 | Dynactin subunit 2 isoform X1. (396 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2367 aa) |
| | NDE1-2 | Nuclear distribution protein nudE homolog 1. (281 aa) |
| | ENSEEUP00000012230 | annotation not available (174 aa) |
| | BOD1L1 | Biorientation of chromosomes in cell division protein 1-like 1. (2842 aa) |
| | ENSEEUP00000012285 | annotation not available (287 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1274 aa) |
| | BUB1B | Mitotic checkpoint serine/threonine-protein kinase BUB1 beta. (1043 aa) |
| | ENSEEUP00000012473 | annotation not available (398 aa) |
| | KMT5B | Lysine methyltransferase 5B. (876 aa) |
| | PSEN2 | Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (454 aa) |
| | TTK | Dual specificity protein kinase TTK. (772 aa) |
| | ENSEEUP00000012664 | annotation not available (413 aa) |
| | NUP98 | Nuclear pore complex protein Nup98-Nup96 isoform X3. (1662 aa) |
| | PPP1R10 | Serine/threonine-protein phosphatase 1 regulatory subunit 10. (911 aa) |
| | MEAF6 | Chromatin modification-related protein MEAF6. (171 aa) |
| | CDK2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | TRAPPC12 | Trafficking protein particle complex subunit 12. (713 aa) |
| | TPR | Nucleoprotein TPR isoform X1. (2317 aa) |
| | SKA2 | Spindle and kinetochore-associated protein 2. (88 aa) |
| | DMC1 | Meiotic recombination protein DMC1/LIM15 homolog isoform X1; Belongs to the RecA family. (323 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (279 aa) |
| | SMC5 | Structural maintenance of chromosomes protein 5. (1093 aa) |
| | SMC6 | Structural maintenance of chromosomes protein 6. (1047 aa) |
| | WRAP53 | WD repeat containing antisense to TP53. (529 aa) |
| | RASSF2 | Ras association domain-containing protein 2. (258 aa) |
| | SIN3A | Paired amphipathic helix protein Sin3a. (1271 aa) |
| | CENPI | Centromere protein I. (743 aa) |
| | ANAPC16 | Anaphase-promoting complex subunit 16. (110 aa) |
| | NSMCE4A | Non-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (287 aa) |
| | XRCC1 | DNA repair protein XRCC1 isoform X2. (631 aa) |
| | ZBTB48 | Zinc finger and BTB domain-containing protein 48 isoform X1. (688 aa) |
| | THOC7 | THO complex subunit 7 homolog. (190 aa) |
| | ENSEEUP00000014024 | annotation not available (1411 aa) |
| | FMR1 | Fragile X mental retardation protein 1 isoform X5. (632 aa) |
| | CHMP4C | Charged multivesicular body protein 4c isoform X1. (168 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4. (1553 aa) |
| | CHMP6 | Charged multivesicular body protein 6. (116 aa) |
| | AURKB | Aurora kinase B; Belongs to the protein kinase superfamily. (340 aa) |
| | NUP85 | Nuclear pore complex protein Nup85; Functions as a component of the nuclear pore complex (NPC). (656 aa) |
| | ERCC6L | DNA excision repair protein ERCC-6-like. (1241 aa) |
| | MACROH2A1 | Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (372 aa) |
| | SEH1L | SEH1 like nucleoporin. (365 aa) |
| | SGO2 | LOW QUALITY PROTEIN: shugoshin-like 2. (1162 aa) |
| | INCENP | Inner centromere protein isoform X2. (869 aa) |
| | ENSEEUP00000005380 | annotation not available (91 aa) |
| | CENPK | Centromere protein K. (273 aa) |
| | ENSEEUP00000005302 | annotation not available (113 aa) |
| | CCDC155 | Coiled-coil domain containing 155. (537 aa) |
| | ENSEEUP00000005030 | annotation not available (419 aa) |
| | NCAPD3 | Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1495 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (625 aa) |
| | ENSEEUP00000004813 | annotation not available (1112 aa) |
| | ITGB3BP | Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. (160 aa) |
| | ENSEEUP00000004780 | annotation not available (1060 aa) |
| | ENSEEUP00000004704 | annotation not available (1610 aa) |
| | ENSEEUP00000004702 | annotation not available (912 aa) |
| | SGO1 | Shugoshin-like 1. (522 aa) |
| | WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa) |
| | PHF6 | PHD finger protein 6 isoform X2. (360 aa) |
| | ESCO2 | LOW QUALITY PROTEIN: N-acetyltransferase ESCO2. (578 aa) |
| | CBX1 | Chromobox protein homolog 1. (185 aa) |
| | ENSEEUP00000004408 | annotation not available (370 aa) |
| | ENSEEUP00000004383 | annotation not available (432 aa) |
| | ENSEEUP00000004369 | annotation not available (1233 aa) |
| | TNKS | Poly [ADP-ribose] polymerase. (1328 aa) |
| | GAR1 | H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (223 aa) |
| | HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (550 aa) |
| | CENPO | Centromere protein O. (280 aa) |
| | MIS12 | Protein MIS12 homolog. (206 aa) |
| | MIS18A | Protein Mis18-alpha. (234 aa) |
| | ENSEEUP00000003840 | annotation not available (191 aa) |
| | ENSEEUP00000003760 | annotation not available (2208 aa) |
| | RASSF4 | Ras association domain-containing protein 4. (396 aa) |
| | ENSEEUP00000003494 | annotation not available (302 aa) |
| | SUV39H2 | Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (351 aa) |
| | ENSEEUP00000003430 | annotation not available (2068 aa) |
| | KIF2C | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (725 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa) |
| | RANGAP1 | Ran GTPase-activating protein 1. (619 aa) |
| | PPP1CC | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (337 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (436 aa) |
| | NSMCE1 | Non-structural maintenance of chromosomes element 1 homolog. (220 aa) |
| | LRIF1 | Ligand-dependent nuclear receptor-interacting factor 1. (617 aa) |
| | ENSEEUP00000002862 | annotation not available (684 aa) |
| | ENSEEUP00000002783 | annotation not available (944 aa) |
| | ENSEEUP00000002614 | annotation not available (221 aa) |
| | RBBP4 | Histone-binding protein RBBP4 isoform X1. (425 aa) |
| | KAT8 | Lysine acetyltransferase 8. (426 aa) |
| | ENSEEUP00000002320 | annotation not available (427 aa) |
| | ENSEEUP00000002216 | annotation not available (543 aa) |
| | NSL1 | NSL1 component of MIS12 kinetochore complex. (283 aa) |
| | STN1 | STN1 subunit of CST complex. (369 aa) |
| | NUP107 | Nuclear pore complex protein; Functions as a component of the nuclear pore complex (NPC). (758 aa) |
| | NUP43 | Nucleoporin Nup43. (433 aa) |
| | DCTN3 | Dynactin subunit 3 isoform X3. (137 aa) |
| | ACD | Adrenocortical dysplasia protein homolog isoform X1. (528 aa) |
| | ENSEEUP00000001610 | annotation not available (275 aa) |
| | ENSEEUP00000001587 | annotation not available (648 aa) |
| | NUP37 | Nucleoporin Nup37. (207 aa) |
| | ENSEEUP00000001501 | annotation not available (453 aa) |
| | ZNF207 | LOW QUALITY PROTEIN: BUB3-interacting and GLEBS motif-containing protein ZNF207-like. (444 aa) |
| | RAD51D | DNA repair protein RAD51 homolog 4 isoform X1. (327 aa) |
| | RAD21 | Double-strand-break repair protein rad21 homolog. (631 aa) |
| | BLM | Bloom syndrome protein. (1383 aa) |
| | KIF2B | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (364 aa) |
| | NABP2 | SOSS complex subunit B1. (204 aa) |
| | MTA2 | Metastasis-associated protein MTA2 isoform X2. (602 aa) |
| | BAZ1B | Tyrosine-protein kinase BAZ1B. (1403 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (436 aa) |
| | LOC103115869 | SOSS complex subunit B1-like. (205 aa) |
| | SKA1 | Spindle and kinetochore-associated protein 1. (249 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1311 aa) |
| | NDE1 | nudE neurodevelopment protein 1. (315 aa) |
| | NUF2 | Kinetochore protein Nuf2. (420 aa) |
| | PHF2 | Lysine-specific demethylase PHF2. (1032 aa) |
| | ENSEEUP00000000443 | annotation not available (608 aa) |
| | NSMCE2 | E3 SUMO-protein ligase NSE2. (208 aa) |
| | FBXO28 | F-box only protein 28. (279 aa) |
| | ENSEEUP00000000332 | annotation not available (330 aa) |
| | ENSEEUP00000000207 | annotation not available (294 aa) |
| | BAZ1A | Bromodomain adjacent to zinc finger domain 1A. (1519 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | TFIP11 | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] (738 aa) |
| | CCDC79 | Telomere repeats-binding bouquet formation protein 1. (493 aa) |
