(35 nodes) ATP-dependent chromatin remodeler activity network (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CHD8	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2299 aa)
	CHD1L	chromodomain-helicase-DNA-binding protein 1-like isoform X1. (873 aa)
	CHD5	Chromodomain helicase DNA binding protein 5. (1924 aa)
	CHD2	chromodomain-helicase-DNA-binding protein 2. (1635 aa)
	SHPRH	E3 ubiquitin-protein ligase SHPRH. (1425 aa)
	RAD54L2	Helicase ARIP4. (1355 aa)
	ENSEEUP00000001566	annotation not available (497 aa)
	EP400	E1A-binding protein p400. (2972 aa)
	HLTF	Helicase-like transcription factor isoform X2. (1009 aa)
	ENSEEUP00000014207	annotation not available (1505 aa)
	ERCC6L	DNA excision repair protein ERCC-6-like. (1241 aa)
	CHD3	chromodomain-helicase-DNA-binding protein 3 isoform X4. (1962 aa)
	SMARCAD1	annotation not available (1004 aa)
	SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (966 aa)
	CHD9	chromodomain-helicase-DNA-binding protein 9 isoform X1. (2785 aa)
	CHD7	chromodomain-helicase-DNA-binding protein 7. (2994 aa)
	SMARCA5	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (993 aa)
	ENSEEUP00000011284	annotation not available (748 aa)
	TTF2	Transcription termination factor 2. (1150 aa)
	ENSEEUP00000010821	annotation not available (1785 aa)
	ZRANB3	DNA annealing helicase and endonuclease ZRANB3 isoform X1. (1000 aa)
	ENSEEUP00000010090	annotation not available (245 aa)
	RSF1	Remodeling and spacing factor 1. (1423 aa)
	INO80	DNA helicase INO80. (1532 aa)
	ERCC6L2	LOW QUALITY PROTEIN: DNA excision repair protein ERCC-6-like 2. (708 aa)
	CHD6	chromodomain-helicase-DNA-binding protein 6. (2712 aa)
	ERCC6	DNA excision repair protein ERCC-6. (1468 aa)
	MPHOSPH9	M-phase phosphoprotein 9. (1029 aa)
	RAD54L	DNA repair and recombination protein RAD54-like. (747 aa)
	RAD54B	DNA repair and recombination protein RAD54B. (904 aa)
	CECR2	Cat eye syndrome critical region protein 2 isoform X2. (1085 aa)
	ENSEEUP00000007055	annotation not available (2488 aa)
	SRCAP	Helicase SRCAP. (2633 aa)
	CHD1	Chromodomain helicase DNA binding protein 1. (1710 aa)
	SMARCAL1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (843 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CECR2	CHD1	ENSEEUP00000007356	ENSEEUP00000006075	Cat eye syndrome critical region protein 2 isoform X2.	Chromodomain helicase DNA binding protein 1.	0.478
CECR2	CHD1L	ENSEEUP00000007356	ENSEEUP00000002825	Cat eye syndrome critical region protein 2 isoform X2.	chromodomain-helicase-DNA-binding protein 1-like isoform X1.	0.742
CECR2	CHD2	ENSEEUP00000007356	ENSEEUP00000001677	Cat eye syndrome critical region protein 2 isoform X2.	chromodomain-helicase-DNA-binding protein 2.	0.478
CECR2	CHD3	ENSEEUP00000007356	ENSEEUP00000013928	Cat eye syndrome critical region protein 2 isoform X2.	chromodomain-helicase-DNA-binding protein 3 isoform X4.	0.466
CECR2	CHD5	ENSEEUP00000007356	ENSEEUP00000002571	Cat eye syndrome critical region protein 2 isoform X2.	Chromodomain helicase DNA binding protein 5.	0.436
CECR2	CHD6	ENSEEUP00000007356	ENSEEUP00000008143	Cat eye syndrome critical region protein 2 isoform X2.	chromodomain-helicase-DNA-binding protein 6.	0.536
CECR2	CHD7	ENSEEUP00000007356	ENSEEUP00000012443	Cat eye syndrome critical region protein 2 isoform X2.	chromodomain-helicase-DNA-binding protein 7.	0.478
CECR2	CHD8	ENSEEUP00000007356	ENSEEUP00000003283	Cat eye syndrome critical region protein 2 isoform X2.	Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...]	0.478
CECR2	CHD9	ENSEEUP00000007356	ENSEEUP00000013327	Cat eye syndrome critical region protein 2 isoform X2.	chromodomain-helicase-DNA-binding protein 9 isoform X1.	0.525
CECR2	ENSEEUP00000001566	ENSEEUP00000007356	ENSEEUP00000001566	Cat eye syndrome critical region protein 2 isoform X2.	annotation not available	0.446
CECR2	ENSEEUP00000007055	ENSEEUP00000007356	ENSEEUP00000007055	Cat eye syndrome critical region protein 2 isoform X2.	annotation not available	0.445
CECR2	ENSEEUP00000010090	ENSEEUP00000007356	ENSEEUP00000010090	Cat eye syndrome critical region protein 2 isoform X2.	annotation not available	0.446
CECR2	ENSEEUP00000010821	ENSEEUP00000007356	ENSEEUP00000010821	Cat eye syndrome critical region protein 2 isoform X2.	annotation not available	0.466
CECR2	ENSEEUP00000011284	ENSEEUP00000007356	ENSEEUP00000011284	Cat eye syndrome critical region protein 2 isoform X2.	annotation not available	0.916
CECR2	EP400	ENSEEUP00000007356	ENSEEUP00000000581	Cat eye syndrome critical region protein 2 isoform X2.	E1A-binding protein p400.	0.525
CECR2	ERCC6	ENSEEUP00000007356	ENSEEUP00000007796	Cat eye syndrome critical region protein 2 isoform X2.	DNA excision repair protein ERCC-6.	0.684
CECR2	ERCC6L	ENSEEUP00000007356	ENSEEUP00000014359	Cat eye syndrome critical region protein 2 isoform X2.	DNA excision repair protein ERCC-6-like.	0.446
CECR2	ERCC6L2	ENSEEUP00000007356	ENSEEUP00000008533	Cat eye syndrome critical region protein 2 isoform X2.	LOW QUALITY PROTEIN: DNA excision repair protein ERCC-6-like 2.	0.446
CECR2	HLTF	ENSEEUP00000007356	ENSEEUP00000014144	Cat eye syndrome critical region protein 2 isoform X2.	Helicase-like transcription factor isoform X2.	0.497
CECR2	INO80	ENSEEUP00000007356	ENSEEUP00000008906	Cat eye syndrome critical region protein 2 isoform X2.	DNA helicase INO80.	0.446