STRINGSTRING
CCAR2 CCAR2 PARP9 PARP9 VPS72 VPS72 FGF10 FGF10 FBH1 FBH1 ENSEEUP00000000513 ENSEEUP00000000513 BABAM2 BABAM2 EP400 EP400 PARP3 PARP3 UIMC1 UIMC1 NKX3-1 NKX3-1 MYC MYC ARID2 ARID2 BCL7C BCL7C RBBP8 RBBP8 RAD51AP1 RAD51AP1 TIMELESS TIMELESS PLA2R1 PLA2R1 PCNA PCNA MAP3K20 MAP3K20 YEATS4 YEATS4 ENSEEUP00000002851 ENSEEUP00000002851 NSMCE1 NSMCE1 ENSEEUP00000003178 ENSEEUP00000003178 ABRAXAS1 ABRAXAS1 ZNHIT1 ZNHIT1 POGZ POGZ ENSEEUP00000003620 ENSEEUP00000003620 SPIRE2 SPIRE2 ZCWPW1 ZCWPW1 ERCC8 ERCC8 DHX9 DHX9 FUS FUS ENSEEUP00000004905 ENSEEUP00000004905 WAS WAS EYA4 EYA4 SLF1 SLF1 MBTD1 MBTD1 FMR1 FMR1 BCL7A BCL7A ANKRD1 ANKRD1 SPIRE1 SPIRE1 XRCC1 XRCC1 NSMCE4A NSMCE4A UBE2V2 UBE2V2 WRAP53 WRAP53 MRGBP MRGBP RPS3 RPS3 MEAF6 MEAF6 EYA2 EYA2 EPC2 EPC2 KMT5B KMT5B DTX3L DTX3L SLF2 SLF2 ACTR8 ACTR8 EYA3 EYA3 FXR2 FXR2 NFRKB NFRKB SIRT1 SIRT1 RIF1 RIF1 EGFR EGFR ENSEEUP00000011699 ENSEEUP00000011699 ING4 ING4 ING3 ING3 CEBPG CEBPG TRIM28 TRIM28 ENSEEUP00000011467 ENSEEUP00000011467 ENSEEUP00000011377 ENSEEUP00000011377 PARP1 PARP1 RUVBL1 RUVBL1 ATR ATR LOC103117148 LOC103117148 INO80D INO80D SPRED1 SPRED1 ENSEEUP00000009948 ENSEEUP00000009948 FAM168A FAM168A MCRS1 MCRS1 MFSD11 MFSD11 RNF168 RNF168 INO80 INO80 ENSEEUP00000008743 ENSEEUP00000008743 TIGAR TIGAR PBK PBK FOXM1 FOXM1 ENSEEUP00000007939 ENSEEUP00000007939 BCLAF1 BCLAF1 ERCC6 ERCC6 ENSEEUP00000007672 ENSEEUP00000007672 BRCC3 BRCC3 ATM ATM EPC1 EPC1 PRKDC PRKDC RNF8 RNF8 HDAC10 HDAC10 FXR1 FXR1 WDR48 WDR48 SKIL SKIL SPIDR SPIDR TTI2 TTI2 DMAP1 DMAP1 SMCHD1 SMCHD1 EEF1E1 EEF1E1 BRD8 BRD8 MAD2L2 MAD2L2 MORF4L2 MORF4L2 MMS19 MMS19
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CCAR2Cell cycle and apoptosis regulator protein 2 isoform X1. (917 aa)
PARP9Poly [ADP-ribose] polymerase 9. (715 aa)
VPS72Vacuolar protein sorting-associated protein 72 homolog. (364 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
FBH1F-box DNA helicase 1 isoform X1. (977 aa)
ENSEEUP00000000513annotation not available (566 aa)
BABAM2BRCA1-A complex subunit BRE. (370 aa)
EP400E1A-binding protein p400. (2972 aa)
PARP3Poly [ADP-ribose] polymerase. (536 aa)
UIMC1BRCA1-A complex subunit RAP80 isoform X1. (671 aa)
NKX3-1Homeobox protein Nkx-3.1 isoform X1. (220 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ARID2AT-rich interactive domain-containing protein 2 isoform X1. (1766 aa)
BCL7CB-cell CLL/lymphoma 7 protein family member C. (164 aa)
RBBP8DNA endonuclease RBBP8. (903 aa)
RAD51AP1RAD51-associated protein 1 isoform X1. (201 aa)
TIMELESSTimeless circadian regulator. (1214 aa)
PLA2R1LOW QUALITY PROTEIN: secretory phospholipase A2 receptor-like. (1447 aa)
PCNAProliferating cell nuclear antigen. (259 aa)
MAP3K20Mitogen-activated protein kinase kinase kinase MLT isoform X1. (801 aa)
YEATS4YEATS domain-containing protein 4 isoform X1. (227 aa)
ENSEEUP00000002851annotation not available (426 aa)
NSMCE1Non-structural maintenance of chromosomes element 1 homolog. (220 aa)
ENSEEUP00000003178annotation not available (555 aa)
ABRAXAS1Helicase POLQ-like isoform X5. (410 aa)
ZNHIT1Zinc finger HIT domain-containing protein 1 isoform X2. (150 aa)
POGZPogo transposable element with ZNF domain isoform X3. (1318 aa)
ENSEEUP00000003620annotation not available (206 aa)
SPIRE2Protein spire homolog 2 isoform X2. (721 aa)
ZCWPW1Zinc finger CW-type PWWP domain protein 1. (501 aa)
ERCC8DNA excision repair protein ERCC-8. (395 aa)
DHX9ATP-dependent RNA helicase A isoform X1. (1265 aa)
FUSRNA-binding protein FUS isoform X1. (519 aa)
ENSEEUP00000004905annotation not available (297 aa)
WASwiskott-Aldrich syndrome protein. (503 aa)
EYA4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (637 aa)
SLF1LOW QUALITY PROTEIN: SMC5-SMC6 complex localization factor protein 1. (1057 aa)
MBTD1MBT domain-containing protein 1 isoform X2. (577 aa)
FMR1Fragile X mental retardation protein 1 isoform X5. (632 aa)
BCL7ABAF chromatin remodeling complex subunit BCL7A. (221 aa)
ANKRD1Ankyrin repeat domain-containing protein 1. (184 aa)
SPIRE1Protein spire homolog 1 isoform X3. (582 aa)
XRCC1DNA repair protein XRCC1 isoform X2. (631 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (287 aa)
UBE2V2Ubiquitin conjugating enzyme E2 V2. (144 aa)
WRAP53WD repeat containing antisense to TP53. (529 aa)
MRGBPMRG/MORF4L-binding protein. (153 aa)
RPS340S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
MEAF6Chromatin modification-related protein MEAF6. (171 aa)
EYA2EYA transcriptional coactivator and phosphatase 2. (538 aa)
EPC2Enhancer of polycomb homolog. (735 aa)
KMT5BLysine methyltransferase 5B. (876 aa)
DTX3LE3 ubiquitin-protein ligase DTX3L. (737 aa)
SLF2SMC5-SMC6 complex localization factor protein 2. (1180 aa)
ACTR8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (577 aa)
EYA3Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (568 aa)
FXR2Fragile X mental retardation syndrome-related protein 2. (676 aa)
NFRKBNuclear factor related to kappa-B-binding protein. (1319 aa)
SIRT1NAD-dependent protein deacetylase sirtuin-1. (595 aa)
RIF1Replication timing regulatory factor 1. (2367 aa)
EGFRReceptor protein-tyrosine kinase. (1212 aa)
ENSEEUP00000011699annotation not available (481 aa)
ING4Inhibitor of growth protein. (244 aa)
ING3Inhibitor of growth protein. (380 aa)
CEBPGCCAAT/enhancer-binding protein gamma. (150 aa)
TRIM28Transcription intermediary factor 1-beta. (624 aa)
ENSEEUP00000011467annotation not available (851 aa)
ENSEEUP00000011377annotation not available (827 aa)
PARP1Poly [ADP-ribose] polymerase. (1016 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (338 aa)
ATRSerine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa)
LOC103117148UPF0544 protein C5orf45 homolog. (301 aa)
INO80DINO80 complex subunit D. (876 aa)
SPRED1Sprouty-related, EVH1 domain-containing protein 1. (444 aa)
ENSEEUP00000009948annotation not available (317 aa)
FAM168AProtein FAM168A isoform X2. (243 aa)
MCRS1Microspherule protein 1. (458 aa)
MFSD11Major facilitator superfamily domain containing 11. (449 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (348 aa)
INO80DNA helicase INO80. (1532 aa)
ENSEEUP00000008743annotation not available (183 aa)
TIGARFructose-2,6-bisphosphatase TIGAR. (270 aa)
PBKLymphokine-activated killer T-cell-originated protein kinase. (323 aa)
FOXM1Forkhead box protein M1 isoform X2. (611 aa)
ENSEEUP00000007939annotation not available (84 aa)
BCLAF1Bcl-2-associated transcription factor 1 isoform X1. (917 aa)
ERCC6DNA excision repair protein ERCC-6. (1468 aa)
ENSEEUP00000007672annotation not available (902 aa)
BRCC3Lys-63-specific deubiquitinase BRCC36. (277 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
EPC1Enhancer of polycomb homolog. (804 aa)
PRKDCDNA-dependent protein kinase catalytic subunit. (4126 aa)
RNF8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (451 aa)
HDAC10Histone deacetylase 10 isoform X1. (663 aa)
FXR1Fragile X mental retardation syndrome-related protein 1 isoform X4. (621 aa)
WDR48WD repeat-containing protein 48 isoform X1. (651 aa)
SKILSki-like protein isoform X1. (406 aa)
SPIDRDNA repair-scaffolding protein. (892 aa)
TTI2TELO2-interacting protein 2. (500 aa)
DMAP1DNA methyltransferase 1-associated protein 1 isoform X1. (472 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain-containing protein 1. (1290 aa)
EEF1E1Eukaryotic translation elongation factor 1 epsilon-1 isoform X1. (128 aa)
BRD8Bromodomain-containing protein 8 isoform X1. (1229 aa)
MAD2L2Mitotic spindle assembly checkpoint protein MAD2B. (216 aa)
MORF4L2Mortality factor 4-like protein 2. (289 aa)
MMS19MMS19 homolog, cytosolic iron-sulfur assembly component. (1028 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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