STRINGSTRING
RCBTB2 RCBTB2 ENSEEUP00000000369 ENSEEUP00000000369 LOC103121078 LOC103121078 LOC103121073 LOC103121073 LOC103121078-2 LOC103121078-2 PPP6R2 PPP6R2 ENSEEUP00000000947 ENSEEUP00000000947 BLM BLM CCNA1 CCNA1 ACD ACD RPA1 RPA1 H3F3A H3F3A PRIM2 PRIM2 STN1 STN1 H2BC3 H2BC3 RBBP4 RBBP4 ENSEEUP00000002591 ENSEEUP00000002591 ENSEEUP00000002608 ENSEEUP00000002608 H2BC1 H2BC1 ENSEEUP00000002779 ENSEEUP00000002779 PCNA PCNA DKC1 DKC1 PIF1 PIF1 ENSEEUP00000003430 ENSEEUP00000003430 MIS18A MIS18A CENPO CENPO GAR1 GAR1 ENSEEUP00000004328 ENSEEUP00000004328 ENSEEUP00000004383 ENSEEUP00000004383 ENSEEUP00000004408 ENSEEUP00000004408 WRN WRN ITGB3BP ITGB3BP ENSEEUP00000004813 ENSEEUP00000004813 ENSEEUP00000004885 ENSEEUP00000004885 CENPK CENPK PPP6R3 PPP6R3 H2BC18 H2BC18 LOC103121073-2 LOC103121073-2 LOC103123915 LOC103123915 ENSEEUP00000005701 ENSEEUP00000005701 POLD2 POLD2 ENSEEUP00000005780 ENSEEUP00000005780 OIP5 OIP5 ENSEEUP00000005927 ENSEEUP00000005927 EXD2 EXD2 ENSEEUP00000006554 ENSEEUP00000006554 ENSEEUP00000006577 ENSEEUP00000006577 CENPQ CENPQ ENSEEUP00000006810 ENSEEUP00000006810 ENSEEUP00000007055 ENSEEUP00000007055 CENPW CENPW MIS18BP1 MIS18BP1 ENSEEUP00000007481 ENSEEUP00000007481 ENSEEUP00000007801 ENSEEUP00000007801 RFC4 RFC4 ENSEEUP00000007942 ENSEEUP00000007942 LOC103125078 LOC103125078 DNA2 DNA2 LOC103121078-3 LOC103121078-3 POLD3 POLD3 ENSEEUP00000008137 ENSEEUP00000008137 H2AC4 H2AC4 TERF1 TERF1 RFC3 RFC3 LOC103121073-3 LOC103121073-3 H2BC6 H2BC6 PPP6C PPP6C SHQ1 SHQ1 POLA1 POLA1 RSF1 RSF1 ENSEEUP00000010729 ENSEEUP00000010729 LOC103116073 LOC103116073 ENSEEUP00000011015 ENSEEUP00000011015 CDK3 CDK3 ENSEEUP00000011081 ENSEEUP00000011081 RUVBL1 RUVBL1 HJURP HJURP ANKRD28 ANKRD28 SMARCA5 SMARCA5 RFC5 RFC5 ENSEEUP00000012230 ENSEEUP00000012230 ENSEEUP00000012285 ENSEEUP00000012285 ENSEEUP00000012473 ENSEEUP00000012473 CCNA2 CCNA2 H3-3A H3-3A TRUB1 TRUB1 CDK2 CDK2 H2BU1 H2BU1 ANKRD44 ANKRD44 DSCC1 DSCC1 MEIOB MEIOB WRAP53 WRAP53 CENPI CENPI SMARCA1 SMARCA1 LIG1 LIG1 LOC103121078-4 LOC103121078-4 H3F3A-2 H3F3A-2 LOC103121078-5 LOC103121078-5 H2AZ2 H2AZ2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RCBTB2RCC1 and BTB domain-containing protein 2 isoform X1. (537 aa)
ENSEEUP00000000369annotation not available (121 aa)
LOC103121078Uncharacterized protein LOC103123889 isoform X1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
LOC103121073Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103121078-2Histone H4. (103 aa)
PPP6R2Protein phosphatase 6 regulatory subunit 2. (928 aa)
ENSEEUP00000000947annotation not available (531 aa)
BLMBloom syndrome protein. (1383 aa)
CCNA1cyclin-A1; Belongs to the cyclin family. (413 aa)
ACDAdrenocortical dysplasia protein homolog isoform X1. (528 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
H3F3AHistone H3; Belongs to the histone H3 family. (136 aa)
PRIM2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (452 aa)
STN1STN1 subunit of CST complex. (369 aa)
H2BC3Histone H2B; Belongs to the histone H2B family. (126 aa)
RBBP4Histone-binding protein RBBP4 isoform X1. (425 aa)
ENSEEUP00000002591annotation not available (102 aa)
ENSEEUP00000002608annotation not available (86 aa)
H2BC1Histone H2B; Belongs to the histone H2B family. (127 aa)
ENSEEUP00000002779annotation not available (270 aa)
PCNAProliferating cell nuclear antigen. (259 aa)
DKC1H/ACA ribonucleoprotein complex subunit 4 isoform X1. (424 aa)
PIF1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA [...] (436 aa)
ENSEEUP00000003430annotation not available (2068 aa)
MIS18AProtein Mis18-alpha. (234 aa)
CENPOCentromere protein O. (280 aa)
GAR1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (223 aa)
ENSEEUP00000004328annotation not available (126 aa)
ENSEEUP00000004383annotation not available (432 aa)
ENSEEUP00000004408annotation not available (370 aa)
WRNLOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa)
ITGB3BPCentromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. (160 aa)
ENSEEUP00000004813annotation not available (1112 aa)
ENSEEUP00000004885annotation not available (315 aa)
CENPKCentromere protein K. (273 aa)
PPP6R3Serine/threonine-protein phosphatase 6 regulatory subunit 3-like. (792 aa)
H2BC18Histone H2B; Belongs to the histone H2B family. (126 aa)
LOC103121073-2Histone H2B type 1. (126 aa)
LOC103123915Histone H2B; Belongs to the histone H2B family. (126 aa)
ENSEEUP00000005701annotation not available (1146 aa)
POLD2DNA polymerase delta subunit 2. (466 aa)
ENSEEUP00000005780annotation not available (124 aa)
OIP5Protein Mis18-beta. (228 aa)
ENSEEUP00000005927annotation not available (647 aa)
EXD2Exonuclease 3'-5' domain-containing protein 2. (496 aa)
ENSEEUP00000006554annotation not available (397 aa)
ENSEEUP00000006577annotation not available (598 aa)
CENPQCentromere protein Q. (262 aa)
ENSEEUP00000006810annotation not available (80 aa)
ENSEEUP00000007055annotation not available (2488 aa)
CENPWCentromere protein W isoform X1. (103 aa)
MIS18BP1Mis18-binding protein 1. (869 aa)
ENSEEUP00000007481annotation not available (924 aa)
ENSEEUP00000007801annotation not available (115 aa)
RFC4Replication factor C subunit 4. (363 aa)
ENSEEUP00000007942annotation not available (1207 aa)
LOC103125078H/ACA ribonucleoprotein complex subunit 3. (65 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa)
LOC103121078-3Histone H4. (103 aa)
POLD3DNA polymerase delta subunit 3. (404 aa)
ENSEEUP00000008137annotation not available (338 aa)
H2AC4Histone H2A; Belongs to the histone H2A family. (130 aa)
TERF1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa)
RFC3Replication factor C subunit 3. (353 aa)
LOC103121073-3Histone H2B type 1. (126 aa)
H2BC6Histone H2B type 1. (126 aa)
PPP6CSerine/threonine-protein phosphatase. (279 aa)
SHQ1Protein SHQ1 homolog. (576 aa)
POLA1DNA polymerase alpha 1, catalytic subunit. (1463 aa)
RSF1Remodeling and spacing factor 1. (1423 aa)
ENSEEUP00000010729annotation not available (447 aa)
LOC103116073Histone H2B; Belongs to the histone H2B family. (121 aa)
ENSEEUP00000011015annotation not available (69 aa)
CDK3Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (304 aa)
ENSEEUP00000011081annotation not available (427 aa)
RUVBL1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (338 aa)
HJURPHolliday junction recognition protein. (689 aa)
ANKRD28Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X1. (1084 aa)
SMARCA5SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5. (993 aa)
RFC5Replication factor C subunit 5. (304 aa)
ENSEEUP00000012230annotation not available (174 aa)
ENSEEUP00000012285annotation not available (287 aa)
ENSEEUP00000012473annotation not available (398 aa)
CCNA2cyclin-A2; Belongs to the cyclin family. (256 aa)
H3-3AH3 histone, family 3A. (136 aa)
TRUB1Probable tRNA pseudouridine synthase 1. (359 aa)
CDK2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
H2BU1Histone H2B; Belongs to the histone H2B family. (126 aa)
ANKRD44Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B. (917 aa)
DSCC1DNA replication and sister chromatid cohesion 1. (279 aa)
MEIOBMeiosis-specific with OB domain-containing protein. (214 aa)
WRAP53WD repeat containing antisense to TP53. (529 aa)
CENPICentromere protein I. (743 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (966 aa)
LIG1DNA ligase 1. (919 aa)
LOC103121078-4Histone H4. (103 aa)
H3F3A-2H3 histone, family 3A. (136 aa)
LOC103121078-5Histone H4. (103 aa)
H2AZ2Histone H2A; Belongs to the histone H2A family. (134 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
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