(44 nodes) DNA Damage Bypass network (Erinaceus europaeus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPATA5L1	Spermatogenesis associated 5 like 1. (752 aa)
	RCBTB2	RCC1 and BTB domain-containing protein 2 isoform X1. (537 aa)
	RAD18	E3 ubiquitin-protein ligase RAD18. (440 aa)
	ENSEEUP00000000369	annotation not available (121 aa)
	VCP	Valosin containing protein. (806 aa)
	ENSEEUP00000000947	annotation not available (531 aa)
	ENSEEUP00000000963	annotation not available (618 aa)
	POLH	DNA polymerase eta. (704 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa)
	ENSEEUP00000002093	annotation not available (1887 aa)
	RPS27A	ubiquitin-40S ribosomal protein S27a. (102 aa)
	NPLOC4	Nuclear protein localization protein 4 homolog isoform X2. (539 aa)
	PCNA	Proliferating cell nuclear antigen. (259 aa)
	DDB1	DNA damage-binding protein 1. (1138 aa)
	REV3L	DNA polymerase zeta catalytic subunit. (3075 aa)
	ENSEEUP00000004885	annotation not available (315 aa)
	UBA7	Ubiquitin-like modifier-activating enzyme 7 isoform X2. (810 aa)
	MAD2L2	Mitotic spindle assembly checkpoint protein MAD2B. (216 aa)
	USP31	Ubiquitin carboxyl-terminal hydrolase 31; Belongs to the peptidase C19 family. (1135 aa)
	ENSEEUP00000005701	annotation not available (1146 aa)
	POLD2	DNA polymerase delta subunit 2. (466 aa)
	WDR48	WD repeat-containing protein 48 isoform X1. (651 aa)
	USP1	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (726 aa)
	RFC4	Replication factor C subunit 4. (363 aa)
	POLD3	DNA polymerase delta subunit 3. (404 aa)
	ENSEEUP00000008199	annotation not available (261 aa)
	RFC3	Replication factor C subunit 3. (353 aa)
	UFD1	Ubiquitin recognition factor in ER associated degradation 1. (306 aa)
	ENSEEUP00000008966	annotation not available (111 aa)
	POLE4	DNA polymerase epsilon subunit 4. (97 aa)
	UBE2L6	ubiquitin/ISG15-conjugating enzyme E2 L6. (94 aa)
	SPRTN	sprT-like domain-containing protein Spartan. (481 aa)
	POLE3	DNA polymerase epsilon subunit 3. (147 aa)
	ATAD5	ATPase family AAA domain containing 5. (1813 aa)
	USP10	Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (800 aa)
	RFC5	Replication factor C subunit 5. (304 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1011 aa)
	CUL4B	cullin-4B isoform X1; Belongs to the cullin family. (893 aa)
	TRIM25	E3 ubiquitin/ISG15 ligase TRIM25. (635 aa)
	USP43	Ubiquitin carboxyl-terminal hydrolase 43 isoform X1; Belongs to the peptidase C19 family. (1070 aa)
	POLE2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (516 aa)
	MEIOB	Meiosis-specific with OB domain-containing protein. (214 aa)
	POLI	DNA polymerase iota. (383 aa)
	TRIM47	Tripartite motif-containing protein 47 isoform X2. (413 aa)

Your Current Organism:

Erinaceus europaeus

NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAD5	CUL4B	ENSEEUP00000011589	ENSEEUP00000012607	ATPase family AAA domain containing 5.	cullin-4B isoform X1; Belongs to the cullin family.	0.636
ATAD5	ENSEEUP00000000369	ENSEEUP00000011589	ENSEEUP00000000369	ATPase family AAA domain containing 5.	annotation not available	0.694
ATAD5	ENSEEUP00000000963	ENSEEUP00000011589	ENSEEUP00000000963	ATPase family AAA domain containing 5.	annotation not available	0.580
ATAD5	ENSEEUP00000002093	ENSEEUP00000011589	ENSEEUP00000002093	ATPase family AAA domain containing 5.	annotation not available	0.867
ATAD5	ENSEEUP00000004885	ENSEEUP00000011589	ENSEEUP00000004885	ATPase family AAA domain containing 5.	annotation not available	0.988
ATAD5	ENSEEUP00000005701	ENSEEUP00000011589	ENSEEUP00000005701	ATPase family AAA domain containing 5.	annotation not available	0.544
ATAD5	ENSEEUP00000008966	ENSEEUP00000011589	ENSEEUP00000008966	ATPase family AAA domain containing 5.	annotation not available	0.584
ATAD5	MAD2L2	ENSEEUP00000011589	ENSEEUP00000005386	ATPase family AAA domain containing 5.	Mitotic spindle assembly checkpoint protein MAD2B.	0.652
ATAD5	MEIOB	ENSEEUP00000011589	ENSEEUP00000013330	ATPase family AAA domain containing 5.	Meiosis-specific with OB domain-containing protein.	0.817
ATAD5	PCNA	ENSEEUP00000011589	ENSEEUP00000002812	ATPase family AAA domain containing 5.	Proliferating cell nuclear antigen.	0.977
ATAD5	POLD2	ENSEEUP00000011589	ENSEEUP00000005709	ATPase family AAA domain containing 5.	DNA polymerase delta subunit 2.	0.703
ATAD5	POLE2	ENSEEUP00000011589	ENSEEUP00000013181	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.816
ATAD5	POLE3	ENSEEUP00000011589	ENSEEUP00000011520	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit 3.	0.765
ATAD5	POLE4	ENSEEUP00000011589	ENSEEUP00000009072	ATPase family AAA domain containing 5.	DNA polymerase epsilon subunit 4.	0.711
ATAD5	POLH	ENSEEUP00000011589	ENSEEUP00000001030	ATPase family AAA domain containing 5.	DNA polymerase eta.	0.689
ATAD5	POLI	ENSEEUP00000011589	ENSEEUP00000013587	ATPase family AAA domain containing 5.	DNA polymerase iota.	0.662
ATAD5	RAD18	ENSEEUP00000011589	ENSEEUP00000000205	ATPase family AAA domain containing 5.	E3 ubiquitin-protein ligase RAD18.	0.825
ATAD5	REV1	ENSEEUP00000011589	ENSEEUP00000012337	ATPase family AAA domain containing 5.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.673
ATAD5	REV3L	ENSEEUP00000011589	ENSEEUP00000003247	ATPase family AAA domain containing 5.	DNA polymerase zeta catalytic subunit.	0.793
ATAD5	RFC3	ENSEEUP00000011589	ENSEEUP00000008341	ATPase family AAA domain containing 5.	Replication factor C subunit 3.	0.988