Your Input: | |
| | SPATA5L1 | Spermatogenesis associated 5 like 1. (752 aa) |
| | RNF8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (451 aa) |
| | HELLS | Lymphoid-specific helicase isoform X1. (793 aa) |
| | CNPPD1 | Protein CNPPD1. (241 aa) |
| | PRKDC | DNA-dependent protein kinase catalytic subunit. (4126 aa) |
| | PRPF19 | pre-mRNA-processing factor 19. (504 aa) |
| | ERCC4 | DNA repair endonuclease XPF. (918 aa) |
| | ATM | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa) |
| | BRCC3 | Lys-63-specific deubiquitinase BRCC36. (277 aa) |
| | ENSEEUP00000007519 | annotation not available (1139 aa) |
| | RAD1 | Cell cycle checkpoint protein RAD1. (281 aa) |
| | ENSEEUP00000007599 | annotation not available (317 aa) |
| | ENSEEUP00000007672 | annotation not available (902 aa) |
| | ENSEEUP00000007680 | annotation not available (700 aa) |
| | MRE11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (656 aa) |
| | ALKBH2 | DNA oxidative demethylase ALKBH2 isoform X1. (260 aa) |
| | AQR | RNA helicase aquarius; Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre- mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing. (1517 aa) |
| | ENSEEUP00000003666 | annotation not available (1131 aa) |
| | MDC1 | Mediator of DNA damage checkpoint protein 1 isoform X1. (1523 aa) |
| | ENSEEUP00000003518 | annotation not available (658 aa) |
| | POLR2C | DNA-directed RNA polymerase II subunit RPB3. (275 aa) |
| | ABRAXAS1 | Helicase POLQ-like isoform X5. (410 aa) |
| | CHEK1 | Serine/threonine-protein kinase Chk1 isoform X1; Belongs to the protein kinase superfamily. (476 aa) |
| | REV3L | DNA polymerase zeta catalytic subunit. (3075 aa) |
| | RHNO1 | RAD9-HUS1-RAD1 interacting nuclear orphan 1. (229 aa) |
| | ENSEEUP00000003178 | annotation not available (555 aa) |
| | NUTF2 | Nuclear transport factor 2. (127 aa) |
| | ENSEEUP00000002984 | annotation not available (425 aa) |
| | RNF169 | E3 ubiquitin-protein ligase RNF169. (709 aa) |
| | DDB1 | DNA damage-binding protein 1. (1138 aa) |
| | ENSEEUP00000002916 | annotation not available (218 aa) |
| | ENSEEUP00000002888 | annotation not available (222 aa) |
| | ENSEEUP00000002862 | annotation not available (684 aa) |
| | ENSEEUP00000002851 | annotation not available (426 aa) |
| | CHD1L | chromodomain-helicase-DNA-binding protein 1-like isoform X1. (873 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (302 aa) |
| | PCNA | Proliferating cell nuclear antigen. (259 aa) |
| | H2BC1 | Histone H2B; Belongs to the histone H2B family. (127 aa) |
| | ENSEEUP00000002608 | annotation not available (86 aa) |
| | ENSEEUP00000002591 | annotation not available (102 aa) |
| | NPLOC4 | Nuclear protein localization protein 4 homolog isoform X2. (539 aa) |
| | ENSEEUP00000002522 | annotation not available (706 aa) |
| | H2BC3 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | BRCA1 | Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1812 aa) |
| | ENSEEUP00000002380 | annotation not available (1195 aa) |
| | RHNO1-2 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1. (133 aa) |
| | ENSEEUP00000002216 | annotation not available (543 aa) |
| | RPS27A | ubiquitin-40S ribosomal protein S27a. (102 aa) |
| | ENSEEUP00000002093 | annotation not available (1887 aa) |
| | TIMELESS | Timeless circadian regulator. (1214 aa) |
| | RAD51AP1 | RAD51-associated protein 1 isoform X1. (201 aa) |
| | TDRD3 | Tudor domain-containing protein 3. (650 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (616 aa) |
| | ALKBH3 | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 isoform X1. (287 aa) |
| | POLR2I | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (125 aa) |
| | ANKRD12 | Ankyrin repeat domain-containing protein 12 isoform X1. (1978 aa) |
| | ACD | Adrenocortical dysplasia protein homolog isoform X1. (528 aa) |
| | RBBP8 | DNA endonuclease RBBP8. (903 aa) |
| | RAD51C | DNA repair protein RAD51 homolog 3. (377 aa) |
| | GTF2H5 | General transcription factor IIH subunit 5. (71 aa) |
| | ABL1 | Tyrosine-protein kinase. (925 aa) |
| | CCNA1 | cyclin-A1; Belongs to the cyclin family. (413 aa) |
| | RAD51D | DNA repair protein RAD51 homolog 4 isoform X1. (327 aa) |
| | ENSEEUP00000001330 | annotation not available (782 aa) |
| | RAD51B | DNA repair protein RAD51 homolog 2. (344 aa) |
| | BLM | Bloom syndrome protein. (1383 aa) |
| | RAD23B | UV excision repair protein RAD23 homolog B. (360 aa) |
| | VWA5B2 | Von Willebrand factor A domain-containing protein 5B2. (969 aa) |
| | POLR2A | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1637 aa) |
| | POLH | DNA polymerase eta. (704 aa) |
| | MNAT1 | CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (269 aa) |
| | ENSEEUP00000000963 | annotation not available (618 aa) |
| | POLQ | DNA polymerase theta. (2561 aa) |
| | ERCC3 | TFIIH basal transcription factor complex helicase XPB subunit isoform X1. (733 aa) |
| | ENSEEUP00000000947 | annotation not available (531 aa) |
| | XRCC4 | DNA repair protein XRCC4. (332 aa) |
| | ENSEEUP00000000900 | annotation not available (548 aa) |
| | VCP | Valosin containing protein. (806 aa) |
| | LOC103128582 | Fanconi anemia core complex-associated protein 24-like. (216 aa) |
| | UIMC1 | BRCA1-A complex subunit RAP80 isoform X1. (671 aa) |
| | ENSEEUP00000000645 | annotation not available (588 aa) |
| | RAD50 | DNA repair protein RAD50 isoform X1. (1311 aa) |
| | PARP3 | Poly [ADP-ribose] polymerase. (536 aa) |
| | ANKRD11 | Ankyrin repeat domain-containing protein 11 isoform X1. (2533 aa) |
| | BABAM2 | BRCA1-A complex subunit BRE. (370 aa) |
| | LOC103121078-2 | Histone H4. (103 aa) |
| | ENSEEUP00000000513 | annotation not available (566 aa) |
| | ENSEEUP00000000473 | annotation not available (423 aa) |
| | LOC103121073 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | LOC103121078 | Uncharacterized protein LOC103123889 isoform X1; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa) |
| | ENSEEUP00000000369 | annotation not available (121 aa) |
| | RAD18 | E3 ubiquitin-protein ligase RAD18. (440 aa) |
| | OGG1 | N-glycosylase/DNA lyase. (383 aa) |
| | RCBTB2 | RCC1 and BTB domain-containing protein 2 isoform X1. (537 aa) |
| | NEIL2 | Endonuclease 8-like 2. (284 aa) |
| | ENSEEUP00000011467 | annotation not available (851 aa) |
| | TCEANC2 | Transcription elongation factor A N-terminal and central domain-containing protein 2. (237 aa) |
| | APEX1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (288 aa) |
| | ENSEEUP00000011399 | annotation not available (197 aa) |
| | WDR76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (604 aa) |
| | SPRTN | sprT-like domain-containing protein Spartan. (481 aa) |
| | PARP1 | Poly [ADP-ribose] polymerase. (1016 aa) |
| | PROSER1 | Proline and serine-rich protein 1. (936 aa) |
| | ENSEEUP00000011189 | annotation not available (1002 aa) |
| | VTCN1 | V-set domain-containing T-cell activation inhibitor 1. (271 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (943 aa) |
| | UBE2L6 | ubiquitin/ISG15-conjugating enzyme E2 L6. (94 aa) |
| | FANCE | Fanconi anemia group E protein. (503 aa) |
| | CDK3 | Cyclin-dependent kinase 3 isoform X1; Belongs to the protein kinase superfamily. (304 aa) |
| | PARP2 | Poly [ADP-ribose] polymerase. (580 aa) |
| | ENSEEUP00000011015 | annotation not available (69 aa) |
| | ENSEEUP00000010992 | annotation not available (59 aa) |
| | ATR | Serine/threonine-protein kinase ATR; Belongs to the PI3/PI4-kinase family. (2572 aa) |
| | LOC103116073 | Histone H2B; Belongs to the histone H2B family. (121 aa) |
| | ENSEEUP00000010729 | annotation not available (447 aa) |
| | RPAP3 | RNA polymerase II-associated protein 3 isoform X1. (608 aa) |
| | ENSEEUP00000010627 | annotation not available (1121 aa) |
| | COPS7A | COP9 signalosome complex subunit 7a. (272 aa) |
| | TDG | G/T mismatch-specific thymine DNA glycosylase isoform X1. (363 aa) |
| | MBD4 | Methyl-CpG-binding domain protein 4; Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. (539 aa) |
| | ENKD1 | Enkurin domain-containing protein 1. (305 aa) |
| | POLR2F | DNA-directed RNA polymerases I, II, and III subunit RPABC2. (125 aa) |
| | RMI1 | recQ-mediated genome instability protein 1. (608 aa) |
| | FANCI | Fanconi anemia group I protein isoform X2. (1228 aa) |
| | NEIL3 | Endonuclease 8-like 3. (453 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (279 aa) |
| | TDP2 | tyrosyl-DNA phosphodiesterase 2. (356 aa) |
| | LOC103116283 | General transcription factor IIH subunit 3-like isoform X2. (217 aa) |
| | ALKBH5 | RNA demethylase ALKBH5 isoform X1. (448 aa) |
| | ERCC2 | TFIIH basal transcription factor complex helicase XPD subunit. (729 aa) |
| | EME1 | Crossover junction endonuclease EME1 isoform X1. (563 aa) |
| | LIG3 | DNA ligase. (708 aa) |
| | ENSEEUP00000009565 | annotation not available (605 aa) |
| | RNF111 | E3 ubiquitin-protein ligase Arkadia isoform X3. (869 aa) |
| | AKAP7 | A-kinase anchoring protein 7. (326 aa) |
| | PPIE | Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (279 aa) |
| | POLR2D | DNA-directed RNA polymerase II subunit RPB4. (84 aa) |
| | POLE4 | DNA polymerase epsilon subunit 4. (97 aa) |
| | RNF168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (348 aa) |
| | POLR2B | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1173 aa) |
| | ASCC3 | Activating signal cointegrator 1 complex subunit 3. (1933 aa) |
| | BRCA2 | Breast cancer type 2 susceptibility protein. (3345 aa) |
| | ENSEEUP00000008966 | annotation not available (111 aa) |
| | ENSEEUP00000008948 | annotation not available (167 aa) |
| | ENSEEUP00000008832 | annotation not available (514 aa) |
| | EP300 | Histone acetyltransferase p300. (1983 aa) |
| | H2BC6 | Histone H2B type 1. (126 aa) |
| | ENSEEUP00000008622 | annotation not available (935 aa) |
| | ENSEEUP00000008599 | annotation not available (323 aa) |
| | PHF3 | PHD finger protein 3 isoform X1. (2032 aa) |
| | UFD1 | Ubiquitin recognition factor in ER associated degradation 1. (306 aa) |
| | LOC103121073-3 | Histone H2B type 1. (126 aa) |
| | GTF2H3 | General transcription factor IIH subunit 3. (304 aa) |
| | FANCL | E3 ubiquitin-protein ligase FANCL. (372 aa) |
| | TCEA1 | Transcription elongation factor A protein 1 isoform X1. (115 aa) |
| | RFC3 | Replication factor C subunit 3. (353 aa) |
| | ENSEEUP00000008316 | annotation not available (453 aa) |
| | ENSEEUP00000008199 | annotation not available (261 aa) |
| | PIAS3 | E3 SUMO-protein ligase PIAS3 isoform X2. (405 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (625 aa) |
| | COPS5 | COP9 signalosome complex subunit 5 isoform X1. (334 aa) |
| | ENSEEUP00000004813 | annotation not available (1112 aa) |
| | ENSEEUP00000004780 | annotation not available (1060 aa) |
| | APBB2 | Amyloid beta A4 precursor protein-binding family B member 2 isoform X1. (640 aa) |
| | ENSEEUP00000004580 | annotation not available (624 aa) |
| | WRN | LOW QUALITY PROTEIN: Werner syndrome ATP-dependent helicase. (1264 aa) |
| | ENSEEUP00000004562 | annotation not available (359 aa) |
| | GEN1 | Flap endonuclease GEN homolog 1. (871 aa) |
| | ENSEEUP00000004392 | annotation not available (410 aa) |
| | ENSEEUP00000004328 | annotation not available (126 aa) |
| | ZNF830 | Zinc finger protein 830. (361 aa) |
| | UBE2T | Ubiquitin-conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (137 aa) |
| | ASCC2 | Activating signal cointegrator 1 complex subunit 2. (721 aa) |
| | ERCC8 | DNA excision repair protein ERCC-8. (395 aa) |
| | FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (509 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (753 aa) |
| | EYA4 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (637 aa) |
| | POLL | DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (383 aa) |
| | ENSEEUP00000014511 | annotation not available (150 aa) |
| | H2AZ2 | Histone H2A; Belongs to the histone H2A family. (134 aa) |
| | ENSEEUP00000014419 | annotation not available (65 aa) |
| | LOC103121078-5 | Histone H4. (103 aa) |
| | TCEA3 | Transcription elongation factor A protein 3. (326 aa) |
| | POLR2K | DNA-directed RNA polymerases I, II, and III subunit RPABC4. (51 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa) |
| | LOC103121078-4 | Histone H4. (103 aa) |
| | MUS81 | Crossover junction endonuclease MUS81 isoform X3. (464 aa) |
| | SLX4 | Structure-specific endonuclease subunit SLX4. (1553 aa) |
| | SLF1 | LOW QUALITY PROTEIN: SMC5-SMC6 complex localization factor protein 1. (1057 aa) |
| | PIAS1 | E3 SUMO-protein ligase PIAS1. (397 aa) |
| | DNTT | DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. (512 aa) |
| | PALB2 | Partner and localizer of BRCA2 isoform X2. (1173 aa) |
| | LIG1 | DNA ligase 1. (919 aa) |
| | MUTYH | Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (549 aa) |
| | TRIM47 | Tripartite motif-containing protein 47 isoform X2. (413 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1365 aa) |
| | XPC | DNA repair protein complementing XP-C cells. (912 aa) |
| | XRCC1 | DNA repair protein XRCC1 isoform X2. (631 aa) |
| | POLI | DNA polymerase iota. (383 aa) |
| | ENSEEUP00000013580 | annotation not available (346 aa) |
| | UBE2V2 | Ubiquitin conjugating enzyme E2 V2. (144 aa) |
| | MEIOB | Meiosis-specific with OB domain-containing protein. (214 aa) |
| | TP53 | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa) |
| | NEIL1 | Endonuclease 8-like 1. (389 aa) |
| | POLE2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (516 aa) |
| | USP43 | Ubiquitin carboxyl-terminal hydrolase 43 isoform X1; Belongs to the peptidase C19 family. (1070 aa) |
| | ENSEEUP00000013106 | annotation not available (498 aa) |
| | HMGN2 | Non-histone chromosomal protein HMG-17. (90 aa) |
| | ENSEEUP00000013094 | annotation not available (560 aa) |
| | TRIM25 | E3 ubiquitin/ISG15 ligase TRIM25. (635 aa) |
| | H2BU1 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | PMS2 | Mismatch repair endonuclease PMS2. (845 aa) |
| | FANCD2 | Fanconi anemia group D2 protein. (1462 aa) |
| | CDK2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | ENSEEUP00000012754 | annotation not available (247 aa) |
| | EYA2 | EYA transcriptional coactivator and phosphatase 2. (538 aa) |
| | ENSEEUP00000012657 | annotation not available (1204 aa) |
| | CUL4B | cullin-4B isoform X1; Belongs to the cullin family. (893 aa) |
| | CCNA2 | cyclin-A2; Belongs to the cyclin family. (256 aa) |
| | CDK7 | Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (246 aa) |
| | ENSEEUP00000012445 | annotation not available (336 aa) |
| | ENSEEUP00000012384 | annotation not available (4615 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1011 aa) |
| | ENSEEUP00000012293 | annotation not available (133 aa) |
| | EYA3 | Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (568 aa) |
| | RFC5 | Replication factor C subunit 5. (304 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2367 aa) |
| | APEX2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (509 aa) |
| | WBP1 | WW domain-binding protein 1 isoform X1. (268 aa) |
| | SUMO1 | Small ubiquitin-related modifier. (101 aa) |
| | PMS1 | PMS1 protein homolog 1 isoform X6. (931 aa) |
| | USP10 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (800 aa) |
| | ENSEEUP00000011699 | annotation not available (481 aa) |
| | ERCC1 | DNA excision repair protein ERCC-1 isoform X2. (232 aa) |
| | PPP4C | Serine/threonine-protein phosphatase. (307 aa) |
| | ENSEEUP00000011645 | annotation not available (1440 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1813 aa) |
| | COPS4 | COP9 signalosome complex subunit 4 isoform X1. (380 aa) |
| | POLE3 | DNA polymerase epsilon subunit 3. (147 aa) |
| | GTF2H1 | General transcription factor IIH subunit 1 isoform X1. (424 aa) |
| | TERF1 | Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (433 aa) |
| | H2AC4 | Histone H2A; Belongs to the histone H2A family. (130 aa) |
| | ENSEEUP00000008137 | annotation not available (338 aa) |
| | POLD3 | DNA polymerase delta subunit 3. (404 aa) |
| | LOC103121078-3 | Histone H4. (103 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2. (924 aa) |
| | EXO1 | Exonuclease 1. (772 aa) |
| | RFC4 | Replication factor C subunit 4. (363 aa) |
| | ENSEEUP00000007801 | annotation not available (115 aa) |
| | ERCC6 | DNA excision repair protein ERCC-6. (1468 aa) |
| | TMEM182 | Transmembrane protein 182. (229 aa) |
| | ENSEEUP00000004885 | annotation not available (315 aa) |
| | VWA5A | Von Willebrand factor A domain-containing protein 5A. (734 aa) |
| | ENSEEUP00000004944 | annotation not available (389 aa) |
| | BARD1 | BRCA1-associated RING domain protein 1. (611 aa) |
| | DCLRE1A | DNA cross-link repair 1A protein. (1003 aa) |
| | FANCM | Fanconi anemia group M protein. (1962 aa) |
| | UBA7 | Ubiquitin-like modifier-activating enzyme 7 isoform X2. (810 aa) |
| | XPA | DNA repair protein complementing XP-A cells. (214 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B. (216 aa) |
| | POLM | DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (486 aa) |
| | H2BC18 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | UBXN1 | UBX domain-containing protein 1 isoform X1. (313 aa) |
| | POLR2H | DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (83 aa) |
| | LOC103121073-2 | Histone H2B type 1. (126 aa) |
| | MSH6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1139 aa) |
| | LOC103123915 | Histone H2B; Belongs to the histone H2B family. (126 aa) |
| | USP31 | Ubiquitin carboxyl-terminal hydrolase 31; Belongs to the peptidase C19 family. (1135 aa) |
| | ENSEEUP00000005701 | annotation not available (1146 aa) |
| | POLD2 | DNA polymerase delta subunit 2. (466 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1007 aa) |
| | RAD52 | DNA repair protein RAD52 homolog isoform X1. (391 aa) |
| | SPIDR | DNA repair-scaffolding protein. (892 aa) |
| | CETN3 | Centrin-3 isoform X1. (166 aa) |
| | XRCC3 | DNA repair protein XRCC3 isoform X2. (254 aa) |
| | TDP1 | tyrosyl-DNA phosphodiesterase 1. (610 aa) |
| | WDR48 | WD repeat-containing protein 48 isoform X1. (651 aa) |
| | PARG | poly(ADP-ribose) glycohydrolase isoform X2. (195 aa) |
| | USP1 | Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (726 aa) |
| | EXD2 | Exonuclease 3'-5' domain-containing protein 2. (496 aa) |
| | FAAP20 | Fanconi anemia core complex-associated protein 20. (153 aa) |
| | TOPBP1 | DNA topoisomerase 2-binding protein 1 isoform X1. (1452 aa) |
| | ENSEEUP00000006554 | annotation not available (397 aa) |
| | ENSEEUP00000006572 | annotation not available (1974 aa) |
| | ENSEEUP00000006577 | annotation not available (598 aa) |
| | BAP1 | Ubiquitin carboxyl-terminal hydrolase. (576 aa) |
| | ADPRHL2 | poly(ADP-ribose) glycohydrolase ARH3. (363 aa) |
| | KPNA7 | Importin subunit alpha-8. (356 aa) |
| | POLR2G | RNA polymerase II subunit G. (172 aa) |
| | ENSEEUP00000006794 | annotation not available (388 aa) |
| | ENSEEUP00000006810 | annotation not available (80 aa) |
