STRINGSTRING
LOC103119124 LOC103119124 GSTO2 GSTO2 ATM ATM CASP8 CASP8 ENSEEUP00000007255 ENSEEUP00000007255 C7orf31 C7orf31 BIRC2 BIRC2 PIK3CB PIK3CB ENSEEUP00000007680 ENSEEUP00000007680 LOC103119100 LOC103119100 CASP3 CASP3 ENSEEUP00000008705 ENSEEUP00000008705 BCL2L1 BCL2L1 ENSEEUP00000008935 ENSEEUP00000008935 ENSEEUP00000008939 ENSEEUP00000008939 CASP9 CASP9 ENSEEUP00000009910 ENSEEUP00000009910 MAPK3 MAPK3 ENSEEUP00000010627 ENSEEUP00000010627 ENSEEUP00000010705 ENSEEUP00000010705 CDKN1A CDKN1A PDPK1 PDPK1 ERCC1 ERCC1 AKT1 AKT1 ENSEEUP00000011766 ENSEEUP00000011766 MAP3K5 MAP3K5 LOC103107698 LOC103107698 AKT2 AKT2 MGST1 MGST1 GSTO1 GSTO1 GSTM3 GSTM3 ENSEEUP00000013059 ENSEEUP00000013059 GSTA4 GSTA4 TP53 TP53 LOC103125199 LOC103125199 PIK3CA PIK3CA ENSEEUP00000014100 ENSEEUP00000014100 MSH2 MSH2 ABCC2 ABCC2 MGST3 MGST3 POLH POLH CYCS CYCS PIK3R3 PIK3R3 MAPK1 MAPK1 BRCA1 BRCA1 BAD BAD BIRC3 BIRC3 ENSEEUP00000003141 ENSEEUP00000003141 LOC103107699 LOC103107699 REV3L REV3L ENSEEUP00000003767 ENSEEUP00000003767 ENSEEUP00000004263 ENSEEUP00000004263 ENSEEUP00000004704 ENSEEUP00000004704 ATP7B ATP7B AKT3 AKT3 XPA XPA XIAP XIAP MSH6 MSH6 TOP2B TOP2B FASLG FASLG ERBB2 ERBB2 SLC31A1 SLC31A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103119124Glutathione S-transferase Mu 2-like isoform X1. (234 aa)
GSTO2Glutathione S-transferase omega-2; Belongs to the GST superfamily. (244 aa)
ATMSerine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] (3041 aa)
CASP8Caspase-8; Belongs to the peptidase C14A family. (535 aa)
ENSEEUP00000007255annotation not available (492 aa)
C7orf31Uncharacterized protein C7orf31 homolog. (579 aa)
BIRC2Baculoviral IAP repeat-containing protein 2. (612 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; Belongs to the PI3/PI4-kinase family. (1070 aa)
ENSEEUP00000007680annotation not available (700 aa)
LOC103119100Glutathione S-transferase Mu 2-like isoform X1; Belongs to the GST superfamily. (215 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (277 aa)
ENSEEUP00000008705annotation not available (165 aa)
BCL2L1Bcl-2-like protein 1 isoform X1. (233 aa)
ENSEEUP00000008935annotation not available (215 aa)
ENSEEUP00000008939annotation not available (570 aa)
CASP9Caspase-9 isoform X2; Belongs to the peptidase C14A family. (415 aa)
ENSEEUP00000009910annotation not available (89 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (379 aa)
ENSEEUP00000010627annotation not available (1121 aa)
ENSEEUP00000010705annotation not available (1248 aa)
CDKN1ACyclin-dependent kinase inhibitor 1. (159 aa)
PDPK13-phosphoinositide-dependent protein kinase 1. (549 aa)
ERCC1DNA excision repair protein ERCC-1 isoform X2. (232 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (448 aa)
ENSEEUP00000011766annotation not available (100 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1360 aa)
LOC103107698Glutathione S-transferase A2-like; Belongs to the GST superfamily. (221 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (475 aa)
MGST1Microsomal glutathione S-transferase 1. (81 aa)
GSTO1Glutathione S-transferase omega-1 isoform X1; Belongs to the GST superfamily. (192 aa)
GSTM3Glutathione S-transferase. (225 aa)
ENSEEUP00000013059annotation not available (267 aa)
GSTA4Glutathione S-transferase A4; Belongs to the GST superfamily. (222 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (375 aa)
LOC103125199Apoptosis regulator BAX. (136 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (973 aa)
ENSEEUP00000014100annotation not available (172 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (932 aa)
ABCC2Canalicular multispecific organic anion transporter 1. (1524 aa)
MGST3Microsomal glutathione S-transferase 3 isoform X2. (113 aa)
POLHDNA polymerase eta. (704 aa)
CYCSCytochrome c, somatic; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (103 aa)
PIK3R3Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X2. (395 aa)
MAPK1Mitogen-activated protein kinase 1. (358 aa)
BRCA1Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...] (1812 aa)
BADBcl2-associated agonist of cell death. (165 aa)
BIRC3Baculoviral IAP repeat-containing protein 3. (601 aa)
ENSEEUP00000003141annotation not available (159 aa)
LOC103107699Glutathione S-transferase A2-like; Belongs to the GST superfamily. (194 aa)
REV3LDNA polymerase zeta catalytic subunit. (3075 aa)
ENSEEUP00000003767annotation not available (876 aa)
ENSEEUP00000004263annotation not available (951 aa)
ENSEEUP00000004704annotation not available (1610 aa)
ATP7BCopper-transporting ATPase 2 isoform X1. (1321 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
XPADNA repair protein complementing XP-A cells. (214 aa)
XIAPE3 ubiquitin-protein ligase XIAP. (496 aa)
MSH6DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1139 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1601 aa)
FASLGTumor necrosis factor ligand superfamily member 6; Belongs to the tumor necrosis factor family. (282 aa)
ERBB2Erb-b2 receptor tyrosine kinase 2. (1198 aa)
SLC31A1High affinity copper uptake protein 1. (190 aa)
Your Current Organism:
Erinaceus europaeus
NCBI taxonomy Id: 9365
Other names: E. europaeus, European hedgehog, common hedgehog, western European hedgehog
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.